| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
The objective of this study was to evaluate the long-term efficacy and safety of a new generation stimulator in restoring ventilation and exercise tolerance in case of bilateral laryngeal paralysis..Bilateral stimulation electrodes were placed between the cricoid cartilage and laryngeal abductor muscles. Recurrent laryngeal nerves were sectioned and repaired bilaterally. Stimulus parameter was fixed at 40Hz, with duty cycle 4 seconds on, 4 seconds off. During the denervation phase, PCA stimulation produced only nominal abduction. During the reinnervation phase, synkinetic reinnervation resulted in a narrowed passive airway and paradoxical glottic closure during hypercapnea. Animals were stridorous and could walk for only 1-2 minutes.Bilateral PCA stimulation increased glottal area, equaling that of a normally innervated animal. Exercise tolerance was also normal. There was no evidence of aspiration. Histological findings demonstrated focal granulation tissue and intact muscle fibers.
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