Development of the novel approaches to diagnose and treat head and neck cancer using nanotechnology
| Project/Area Number |
23592520
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
SHIGA Kiyoto 岩手医科大学, 医学部, 教授 (10187338)
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| Co-Investigator(Kenkyū-buntansha) |
KODAMA Tetuya 東北大学, その他の研究科, 教授 (40271986)
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| Co-Investigator(Renkei-kenkyūsha) |
MORI Shirou (80230069)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 頭頸部癌 / 頸部リンパ節転移 / 造影超音波診断 / 血管新生 / マイクロバブル / ナノバブル / 超音波診断 / 腫瘍血管 / 分子導入 |
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| Research Abstract |
It is well known that angiogenic processes in growing tumors promote increased vessel density and structural abnormalities. Lymph node metastasis of the head and neck cancer also showed this neo-vascularization features in active phase of metastasis. The purpose of this study is to evaluate the vascular density and morphology in metastatic lymph nodes by using microbubbles as ultrasound contrast-enhancing agent. On the next stage, we intend to use hybrid nanobubbles to introduce some anti-tumor agents or transformed constructs into cancer cells as drug delivery system. We developed novel image-analyzing software to analyze capillary vessels in lymph nodes of the patients. After they underwent neck dissection, all of the patients who showed contrast-enhancement in their lymph nodes had carcinoma metastases in their lymph nodes by histopathological examination. Contrast ultrasound using our software is useful to detect lymph node metastasis of the head and neck cancer.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Malignant melanoma of the head and neck : A multi-institutional retrospective analysis of cases in Northern Japan2012
Author(s)
Shiga K, Ogawa T, Kobayashi T, Ueda S, Kondo A, Nanba A, Kuwashima S, Asada Y, Suzuki S, Nagahashi T, Takahashi M, Suzuki M, Ishida A, Watanabe K, Harabuchi Y, Himi T, Shinkawa H, Sato H, Saijyo S, Fukuda S, Tanaka K, Ishikawa K, Omori K, Aoyagi M, Hashimoto S
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Journal Title
Head Neck
Volume: (in press)
Issue: 11
Pages: 1537-1541
DOI
Related Report
Peer Reviewed
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[Journal Article] miR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis2012
Author(s)
Takenori Ogawa, Yuriko Saiki, Kiyoto Shiga, Na Chen, Shinichi Fukushige, Makoto Sunamura, Hiroki Nagase, Sho Hashimoto, Kazuto Matsuura, Shigeru Saijo, Toshimitsu Kobayashi, Akira Horii
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Journal Title
Cancer Sci
Volume: 103
Pages: 1737-1743
Related Report
Peer Reviewed
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