| Project/Area Number |
23592521
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Tohoku University |
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Principal Investigator |
KATO KENGO 東北大学, 医学(系)研究科(研究院), 非常勤講師 (40455788)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Nobuyuki 地方独立法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 部長 (60280872)
MATSUURA Kazuto 地方独立法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 特任研究員 (70271947)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 癌 / 癌幹細胞 / EMT / 頭頸部癌 / ポリコム |
|---|
| Research Abstract |
Malignant phenotype of Head and Neck Cancer (HNC) is related to EMT and polycomb gene induction, and emerging evidence suggests a role of EMT/Polycombs on Cancer stem cell (CSC) induction. In this study, we investigated whether EMT and polycomb genes control CSC of HNC cells. Forced expression of the Bmi1, EZH2 and Slug in HNC cell lines induced cancer stemness phenotypes, such as ALDH1 activity. Two inflammatory cytokines, TGFb and TNFa potentiated Bmi1-related CSC phenotypes. These results suggest that polycomb and EMT genes under inflammatory environment regulate malignant phenotypes of HNC.
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