Chemoprevention of Head and neck Cancer utilizing an animal model

• Project/Area Number: 23592531
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kyushu University
• Principal Investigator: NAKASHIMA Torahiko 九州大学, 医学(系)研究科(研究院), 准教授 (00284505)
• Co-Investigator(Kenkyū-buntansha): YASUMATSU Ryuji 九州大学病院, 助教 (00444787)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 頭頸部癌 / 化学予防

Research Abstract

Management of second primary cancers in head nad neck cancer(HNC) patients has been important for head and neck surgeons. There are 20-30% incidence of second primary cancer due to field cancerization of the upper aerodigestive tract.
This study investigated the efffect of retinoic acids for the chemoprevention of HNC utilizing an animal (hamster) model.
13-cis retinoic acid had a effect for preventing cancer in the animal, however no stastisical significance was obtained because the number of animals in the experiment was still small. The experiments are still in progress.

Research Products

• [Journal Article] Japanese Board Certification System for head and neck surgeons. (2014)
  • Author(s): Yoshimoto S, Nakashima T et al.
  • Journal Title: Auris Nasus Larynx. Volume: 41 Issue: 4 Pages: 1175-81
  • DOI: 10.1016/j.anl.2013.10.019
  • Peer Reviewed / Open Access
• [Journal Article] 頭頸部癌の集学的治療における化学放射線治療の位置づけ (2013)
  • Author(s): 中島寅彦
  • Journal Title: 口腔咽頭科 Volume: 26(1) Pages: 56-63
• [Journal Article] Interferon Inducible IFI16 Expression in p16 Positive Squamous Cell Carcinoma of the Oropharynx. (2013)
  • Author(s): Yamauchi M, Nakano T, Nakashima T et al
  • Journal Title: ISRN Otolaryngol. Volume: ００ Pages: 00-00
  • DOI: 10.1155/2013/263271
  • Peer Reviewed
• [Journal Article] 頭頸部扁平上皮癌の最新情報-頭頸部扁平上皮癌の化学予防- (2012)
  • Author(s): 中島寅彦
  • Journal Title: JOHNS Volume: 28(8) Pages: 1161-1164
• [Journal Article] 耳鼻咽喉科医に必要な頭頸部癌に対する化学予防の知識 (2012)
  • Author(s): 中島寅彦
  • Journal Title: 福耳会ニュース Volume: 135号 Pages: 4-6
• [Journal Article] Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma (2012)
  • Author(s): Nakashima T, Yasumatsu R, Masuda M, Clayman GL, Komune S.
  • Journal Title: J Laryngol Otol Volume: 126 Pages: 1134-1137
  • Peer Reviewed
• [Journal Article] HER-2/neu gene amplification in carcinoma ex pleomorphic adenoma in relation to progression and prognosis: a chromogenic in-situ hybridization study. (2012)
  • Author(s): Hashimoto K, Yamamoto H, Shiratsuchi H, Nakashima T, Tamiya S, Nishiyama K, Higaki Y, Komune S, Tsuneyoshi M, Oda Y
  • Journal Title: Histopathology Volume: 60 Pages: 131-142
  • Peer Reviewed
• [Journal Article] Overexpression of the orotate phosphoribosyl-transferase gene enhances the effect of 5-Fluorouracil in head and neck squamous cell carcinoma in vitro. (2012)
  • Author(s): Yasumatsu R, Nakashima T, Komune S
  • Journal Title: J Oncol Volume: 649605 Pages: 1-4
  • Peer Reviewed
• [Journal Article] 頭頸部扁平上皮癌の最新情報 -頭頸部扁平上皮癌の化学予防- (2012)
  • Author(s): 中島寅彦
  • Journal Title: JOHNS Volume: 28 Pages: 1161-1164
• [Journal Article] Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma (2012)
  • Author(s): Nakashima T, Yasumatsu R, Masuda M, Clayman GL, Komune S.
  • Journal Title: J Laryngol Otol. Volume: in press
  • Peer Reviewed
• [Journal Article] 頭頸部癌に対する化学放射線療法の現状と将来展望 (2011)
  • Author(s): 中島寅彦
  • Journal Title: 日気食会報 Volume: 62 Pages: 241-242
• [Presentation] 頭頸部癌に対する分子標的療の現状 (2013)
  • Author(s): 中島寅彦
  • Organizer: 第58回日本口腔外科学会総会・学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2013-10-11
• [Presentation] Is there a role of adjuvant therapy for the treatment of salivary duct carcinoma? (2013)
  • Author(s): Torahiko Nakashima, Ryuji Yasumatsu et al
  • Organizer: AAO-HNSF annual meeting
  • Place of Presentation: Vancouver
• [Presentation] 頭頸部癌に対する分子標的治療の現状 (2013)
  • Author(s): 中島寅彦
  • Organizer: 第58回日本口腔外科学会総会・学術大会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] Is there a role of pre-operative chemoradiotherapy for advanced hypopharyngeal cancer? (2012)
  • Author(s): Torahiko Nakashima, Satoshi Toh, Hideki Shiratsuchi, Ryuji Yasumatsu, Katsumasa Nakamura, Shizuo Komune
  • Organizer: 8th International Conference on HN Cancer
  • Place of Presentation: Toronto
• [Presentation] 唾液腺導管癌（Salivary Duct Carcinoma）に対する集学的治療 (2012)
  • Author(s): 中島寅彦、藤 賢史、白土秀樹、橋本和樹、山元英崇、小宗静男
  • Organizer: 日本頭頸部癌学会総会
  • Place of Presentation: 島根
• [Presentation] Clinical outcome following partial glossectomy or brachytherapy for early stage tongue cancer (2011)
  • Author(s): Torahiko Nakashima, Katsumasa Nakamura, Hideki Shiratsuchi, Satoshi Toh, Ryuji Yasumatsu, Yoshiyuki Shioyama, Shizuo Komune
  • Organizer: Third World Congress of the IAOO
  • Place of Presentation: Singapore
• [Presentation] 明日の診療に役立つ頭頸部癌の基礎研究‐化学予防‐ (2010)
  • Author(s): 中島寅彦
  • Organizer: 第34回日本頭頸部癌学会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-11
• [Presentation] 局所進行下咽頭癌に対する術前化学放射線療法の位置づけ
  • Author(s): 中島寅彦、藤 賢史、白土秀樹、福島純一、塩山善之、小宗静男
  • Organizer: 第35回日本頭頸部癌学会総会
  • Place of Presentation: 名古屋
• [Book] ENT臨床フロンティアがんを見逃さない-頭頸部癌診療の最前線頭頸部癌の化学予防 (2013)
  • Author(s): 中島寅彦
  • Publisher: 中山書店
• [Book] 頭頸部癌診療ガイドライン2013年版日本頭頸部癌学会編 (2013)
  • Author(s): 中島寅彦
  • Publisher: 金原出版
• [Book] ENT臨床フロンティア がんを見逃さない-頭頸部癌診療の最前線 頭頸部癌の化学予防 (2012)
  • Author(s): 中島寅彦
  • Total Pages: 2
  • Publisher: 中山書店
• [Remarks]
  • URL: http://www.qent.med.kyushu-u.ac.jp/