| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
The aim of the study is to predict head and neck squamous cell carcinoma (HNSCC) prognosis before treatment start. The following results were obtained. 1) Gene polymorphism related to alcohol metabolism (ADH1B, ALDH2) and tobacco toxic substances metabolism (CYP1A1, GST) was investigated. The variant allele of I462V mutation in Msp was significantly correlated to carcinoma occurrence of mesopharyngeal carcinoma. 2) Human papillomavirus (HPV) infection was observed in approximately 30% of HNSCC. Of HNSCC with HPV infection, 75% demonstrated HPV integration to the host genome. HPV-related HNSCC prognosis is significantly better than HPV-unrelated HNSCC. 3) Biological activity of tumor: HIF-1 alpha and GLUT1 is highly expressed in HNSCC.
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