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The elucidation of the mechanism in the tracheal epithelial regeneration using technique of tissue engineering

Research Project

Project/Area Number 23592536
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionFukushima Medical University

Principal Investigator

TADA Yasuhiro  福島県立医科大学, 医学部, 講師 (70363760)

Co-Investigator(Kenkyū-buntansha) TAKEZAWA Toshiaki  独立行政法人農業生物資源研究所, 遺伝子組み換え家畜研究センター, 主任研究員 (50301297)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords気管食道科学 / 再生医療 / 人工気管 / 気管欠損 / ビトリゲル / アテロコラーゲン / ブタ / 気管狭窄 / 気道上皮 / コラーゲン
Research Abstract

We changed material of vitrigel to add to collagen sponge in atero collagen derived from a pig from native collagen derived from a cow. As for the tissue rate of absorption, atero collagen is faster than native collagen. We took the quantity of effective atero collagen as 2.2mg/cm2 for epithelium regeneration. The quantity of atero collagen which was necessary for epithelial regeneration was 2.2mg/cm2.
The observation of the post transplantation trachea lumen used rigid endoscope for ears.
Hereby, an evaluation of the epithelization was possible without resecting trachea.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (16 results)

All 2014 2013 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (9 results) (of which Invited: 1 results)

  • [Journal Article] Regenerative Process of tracheal epithelium using a collagen vitrigel sponge scaffold2013

    • Author(s)
      Tani A, Tada Y, Takezawa T, Wada I, Imaizumi M, Nomoto Y, Nomoto M, Omori K
    • Journal Title

      Laryngoscope

      Volume: 123(6) Pages: 1469-1473

    • Related Report
      2013 Final Research Report
  • [Journal Article] Regenerative process of tracheal epithelium using a collagen vitrigel sponge scaffold2013

    • Author(s)
      Akiko T, Yasuhiro T, Toshiaki T et al.
    • Journal Title

      The Laryngoscope

      Volume: 123(6) Issue: 6 Pages: 1469-1473

    • DOI

      10.1002/lary.23742

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Collagen vitrig el scaffold for regenerative medicin e of the trachea : Experimental stu dy and quantitative evaluation2012

    • Author(s)
      Tada Y, Takezawa T, Tani A, Nak amura T, Omori K
    • Journal Title

      Ac ta Oto-Laryngologica

      Volume: 132 Pages: 447-452

    • Related Report
      2013 Final Research Report
  • [Journal Article] Regeneration of Trache al Epithelium Using a Collagen Vi trigel-Sponge Scaffold Containing Basiv Fibroblast Growth Factor2012

    • Author(s)
      Tani A, Tada Y, Takezawa T, Ima izumi M, Nomoto Y, Nakamura T, Omori K
    • Journal Title

      A nn Otol Rhinol Laryngol

      Volume: 121(4) Pages: 261-268

    • Related Report
      2013 Final Research Report
  • [Journal Article] 喉頭・気管狭窄症2012

    • Author(s)
      多田靖宏,鈴木輝久,岡野渉,今泉光雅,谷亜希子,大森孝一
    • Journal Title

      喉頭

      Volume: 24(2) Pages: 85-88

    • NAID

      10031163054

    • Related Report
      2013 Final Research Report
  • [Journal Article] Regeneration of Tracheal Epithelium Using a Collagen Vitrigel-Sponge Scaffold Containing Basiv Fibroblast Growth Factor.2012

    • Author(s)
      Tani A, Tada Y, Takezawa T, Imaizumi M, Nomoto Y, Nakamura T, Omori K
    • Journal Title

      Ann Otol Rhinol Laryngol

      Volume: 121(4) Pages: 261-268

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Collagen vitrigel scaffold for regenerative medicine of the trachea: Experimental study and quantitative evaluation.2012

    • Author(s)
      Tada Y, Takezawa T, Tani A, Nakamura T, Omori K
    • Journal Title

      Acta Oto-Laryngologica

      Volume: 132 Pages: 447-452

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Tracheal regeneration using a collagen vitrigel sponge scaffold containing basic fibroblast growth factor2014

    • Author(s)
      Tani A, Tada Y, Takezawa T, et al
    • Organizer
      The International Bronchoesophagology Society
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Final Research Report
  • [Presentation] ブタ由来コラーゲンビトリゲルを用いた喉頭気管の再建2014

    • Author(s)
      多田靖宏,仲江川雄太,谷亜希子,他
    • Organizer
      第26回日本喉頭科学会
    • Place of Presentation
      沖縄県
    • Related Report
      2013 Final Research Report
  • [Presentation] Traceal regeneration using a collagen vitrigel sponge scaffold containing basic fibroblast growth factor2014

    • Author(s)
      Akiko T, Yasuhiro T,Koichi O
    • Organizer
      The International Bronchoesophagology Society
    • Place of Presentation
      京都市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Regenerative Process of tracheal epithelium using a collagen vitrigel sponge scaffold2012

    • Author(s)
      Tani A, Tada Y, Takezawa T, Wada I, Imaizumi M, Nomoto Y, Nomoto M, Omori K
    • Organizer
      The 133th American Laryngological Association
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 気管を再生する医療技術の開発状況

    • Author(s)
      多田靖宏
    • Organizer
      日本組織培養学会
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Effrct of basic fibroblast growth factor for regeneration of tracheal epithelium using a collagen vitrigelsponge

    • Author(s)
      Akiko Tani, Yasuhiro Tada, Toshiaki Takezawa, Mituyoshi Imaizumi, Yukio Nomoto, Koichi Omori
    • Organizer
      American Laryngeal Association
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] コラーゲンビトリゲルと線維芽細胞増殖因子を用いた気管再建

    • Author(s)
      谷亜希子、多田靖宏、竹澤俊明、大森孝一
    • Organizer
      東北地方部会連合学会
    • Place of Presentation
      仙台市
    • Related Report
      2012 Research-status Report
  • [Presentation] せんいが細胞増殖因子を含有したコラーゲンビトリゲルによる気管粘膜再生

    • Author(s)
      谷亜希子、多田靖宏、大森孝一
    • Organizer
      日本気管食道科学会
    • Place of Presentation
      東京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Evaluation of tracheal epithelium after implantation of a collagen vitrigel sponge containing basic fibroblast growth factor

    • Author(s)
      Akiko Tani, Yasuhiro Tada, Toshiaki Takezawa, Mituyoshi Imaizumi, Yukio Nomoto, Koichi Omori
    • Organizer
      East Asian Conference of Phonosurgery
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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