The elucidation of the mechanism in the tracheal epithelial regeneration using technique of tissue engineering
| Project/Area Number |
23592536
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
TADA Yasuhiro 福島県立医科大学, 医学部, 講師 (70363760)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEZAWA Toshiaki 独立行政法人農業生物資源研究所, 遺伝子組み換え家畜研究センター, 主任研究員 (50301297)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 気管食道科学 / 再生医療 / 人工気管 / 気管欠損 / ビトリゲル / アテロコラーゲン / ブタ / 気管狭窄 / 気道上皮 / コラーゲン |
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| Research Abstract |
We changed material of vitrigel to add to collagen sponge in atero collagen derived from a pig from native collagen derived from a cow. As for the tissue rate of absorption, atero collagen is faster than native collagen. We took the quantity of effective atero collagen as 2.2mg/cm2 for epithelium regeneration. The quantity of atero collagen which was necessary for epithelial regeneration was 2.2mg/cm2.
The observation of the post transplantation trachea lumen used rigid endoscope for ears.
Hereby, an evaluation of the epithelization was possible without resecting trachea.
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Report
(4 results)
Research Products
(16 results)
