| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
In head and neck cancer cells, we investigated whether Wnt/Snail signaling pathway could induce epithelial-mesenchymal transition, EMT, promote the activation of cancer stem cells, and enhance cancer cel invasion and metastasis. As a result, it was found in the in vivo and in vitro study that Wnt/Snail signaling pathway could induce cancer invasion and metastasis though EMT. In addition, the cancer cells induced EMT by Snail could acquire the cancer stem cell-like properties, such as enhancement of treatment-resistant and expression of cancer stem cell marker. Controlling these signaling pathways involved in EMT will lead to controlling the invasion and metastasis of head and neck cancer.
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