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Elucidation of the cancer stem cell activation mechanism by EMT in invasion and metastasis of head and neck cancer

Research Project

Project/Area Number 23592537
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionNara Medical University

Principal Investigator

OTA Ichiro  奈良県立医科大学, 医学部, 助教 (00326323)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Akihisa  群馬大学, 先端科学研究指導者育成ユニット, 准教授 (60275336)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords頭頸部がん / 癌幹細胞 / 浸潤・転移 / EMT / 頭頸部外科学
Research Abstract

In head and neck cancer cells, we investigated whether Wnt/Snail signaling pathway could induce epithelial-mesenchymal transition, EMT, promote the activation of cancer stem cells, and enhance cancer cel invasion and metastasis. As a result, it was found in the in vivo and in vitro study that Wnt/Snail signaling pathway could induce cancer invasion and metastasis though EMT. In addition, the cancer cells induced EMT by Snail could acquire the cancer stem cell-like properties, such as enhancement of treatment-resistant and expression of cancer stem cell marker. Controlling these signaling pathways involved in EMT will lead to controlling the invasion and metastasis of head and neck cancer.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (38 results)

All 2014 2013 2012 2011 Other

All Journal Article (16 results) (of which Peer Reviewed: 14 results,  Open Access: 1 results) Presentation (21 results) Remarks (1 results)

  • [Journal Article] Snail-induced epithelial-mesenchymal transition promotes cancer stem cell-like phenotype in head and neck cancer cells2014

    • Author(s)
      Masui T, Ota I, Yook JI, Mikami S, Yane K, Yamanaka T, Hosoi H
    • Journal Title

      Int J Oncol

      Volume: 44 Pages: 693-699

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Snail-induced epithelial-mesenchymal transition promotes cancer stem cell-like phenotype in head and neck cancer cells2014

    • Author(s)
      Masui T, Ota I, Yook JI, et al.
    • Journal Title

      Int J Oncol.

      Volume: 44 Issue: 3 Pages: 693-699

    • DOI

      10.3892/ijo.2013.2225

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sentinel Lymph Node Detection in Patients with Oral Cancer by MR Lymphography using Superparamagnetic Iron Oxide2013

    • Author(s)
      Uemura H, Ota I, Fujii T, Suzuki M, Sakai M, Nakanishi K, Tomita Y, Noguchi A, Hosoi H, Yoshino K
    • Journal Title

      The Open Otorhinolaryngology Journal

      Volume: 7 Pages: 14-18

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heparin-binding EGF-like growth factor enhances the activity of invasion and metastasis in thyroid cancer cells2013

    • Author(s)
      Ota I, Higashiyama S, Masui T, Yane K, Hosoi H, Matsuura N
    • Journal Title

      Oncol Rep

      Volume: 30 Pages: 1593-1600

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of REG III and prognosis in head and neck cancer2013

    • Author(s)
      Masui T, Ota I, Itaya-Hironaka A, Takeda M, Kasai T, Yamauchi A, Sakuramoto- Tsuchida S, Mikami S, Yane K, Takasawa S, Hosoi H
    • Journal Title

      Oncol Rep

      Volume: 30 Pages: 573-578

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sentinel Lymph Node Detection in Patients with Oral Cancer by MR Lymphography using Superparamagnetic Iron Oxide2013

    • Author(s)
      Uemura H, Ota I, Fujii T, et al.
    • Journal Title

      The Open Otorhinolaryngology Journal.

      Volume: 7 Issue: 1 Pages: 14-18

    • DOI

      10.2174/1874428120131206002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heparin-binding EGF-like growth factor enhances the activity of invasion and metastasis in thyroid cancer cells2013

    • Author(s)
      Ota I, Higashiyama S, Masui T, et al.
    • Journal Title

      Oncol Rep.

      Volume: 30 Issue: 4 Pages: 1593-1600

    • DOI

      10.3892/or.2013.2659

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Depression of p53- independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiation2012

    • Author(s)
      Nakagawa Y, Takahashi A, Kajihara A, Yamakawa N, Imai Y, Ota I, Okamoto N, Mori E, Noda T, Furusawa Y, Kirita T, Ohnishi T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 423(4) Pages: 654-60

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-γ-inducible protein 10 in a casein kinase 2-dependent manner2012

    • Author(s)
      Yoo JY, Choi HK, Choi KC, Park SY, Ota I, Yook JI, Lee YH, Kim K, Yoon H
    • Journal Title

      Mol Biol Cell

      Volume: 23(15) Pages: 2943-2954

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic strategies for head and neck cancer based on p53 status2012

    • Author(s)
      Ota I, Okamoto N, Yane K, Takahashi A, Masui T, Hosoi H, Ohnishi T
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 3 Pages: 585-591

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low-intensity ultrasound enhances the anti-cancer activity of cetuximab in human head and neck cancer cells.2012

    • Author(s)
      Masui T, Ota I, Kanno M, et al.
    • Journal Title

      xperimental and Therapeutic Medicine

      Volume: 5 Issue: 1 Pages: 11-16

    • DOI

      10.3892/etm.2012.739

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Depression of p53-independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiation.2012

    • Author(s)
      Yosuke Nakagawa,Akihisa Takahashi,Atsuhisa Kajihara,Nobuhiro Yamakawa,Yuichiro Imai,Ichiro Ota,Noritomo Okamoto,Eiichiro Mori,Taichi Noda,Yoshiya Furusawa,Tadaaki Kirita,Takeo Ohnishi
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 423 (4) Issue: 4 Pages: 654-660

    • DOI

      10.1016/j.bbrc.2012.06.004

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-γ-inducible protein 10 in a casein kinase 2-dependent manner.2012

    • Author(s)
      Yoo JY, Choi HK, Ota I, et al.
    • Journal Title

      Mol Biol Cell.

      Volume: 23 Issue: 15 Pages: 2943-2954

    • DOI

      10.1091/mbc.e11-11-0947

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【耳鼻咽喉科疾患と遺伝子】頭頸部癌と遺伝子2012

    • Author(s)
      太田一郎、家根旦有
    • Journal Title

      耳鼻咽喉科・頭頸部外科

      Volume: 84 Pages: 910-914

    • Related Report
      2012 Research-status Report
  • [Journal Article] 【頭頸部扁平上皮癌の最新情報】 頭頸部扁平上皮癌に対する新しい治療戦略 癌免疫治療と分子標的薬治療2012

    • Author(s)
      太田一郎
    • Journal Title

      JOHNS

      Volume: 28 Pages: 1191-1196

    • Related Report
      2012 Research-status Report
  • [Journal Article] siRNA targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells2011

    • Author(s)
      Okamoto N, Takahashi A, Ota I, Ohnishi K, Mori E, Kondo N, Noda T, Nakagawa Y, Uemura H, Yane K, Hosoi H, Ohnishi T
    • Journal Title

      Int J Hyperthermia

      Volume: 27 Pages: 297-304

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 糖尿病と癌の進展-高血糖は癌の浸潤を促進させる(1)-2013

    • Author(s)
      太田一郎、桝井貴史、三上慎司、細井裕司
    • Organizer
      日耳鼻大阪地方連合会327回例会
    • Place of Presentation
      大阪市
    • Year and Date
      2013-12-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 下咽頭癌におけるREGIIIの発現と治療感受性2013

    • Author(s)
      桝井貴史、太田一郎、広中安佐子、武田麻衣子、笠井孝彦、山内晶世、土田澄代、高沢伸、細井裕司
    • Organizer
      第37回日本頭頸部癌学会
    • Place of Presentation
      東京都
    • Year and Date
      2013-06-04
    • Related Report
      2013 Final Research Report
  • [Presentation] がん研究UP TO DATE 2013世界の基礎研究の動向2013

    • Author(s)
      太田一郎
    • Organizer
      第7回頭頸部癌基礎研究会
    • Place of Presentation
      東京都
    • Year and Date
      2013-06-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖尿病と癌の進展-高血糖は癌の浸潤を促進させる-2013

    • Author(s)
      太田一郎、桝井貴史、三上慎司、細井裕司
    • Organizer
      日本耳鼻咽喉科学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2013-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Low-intensity ultrasound enhances the anti-cancer activity of cetuximab in human head and neck cancer cells2013

    • Author(s)
      Ota I, Masui T, Uemura K, Kanno M, Yane K, Hosoi H
    • Organizer
      III Eurasian Head & Neck Cancer Forum
    • Place of Presentation
      Petersburg, Russia
    • Related Report
      2013 Final Research Report
  • [Presentation] 1. Low-intensity ultrasound enhances the anti-cancer activity of cetuximab in human head and neck cancer cells2013

    • Author(s)
      Ichiro Ota, Takashi Masui, Kazuhiro Uemura, et al.
    • Organizer
      III Eurasian Head & Neck Cancer Forum
    • Place of Presentation
      St. Petersburg, Russia
    • Related Report
      2013 Annual Research Report
  • [Presentation] 頭頸部癌細胞におけるEGFRをターゲットにした分子標的治療の超音波照射による増感効果2012

    • Author(s)
      太田一郎, 桝井貴史, 神野正敏, 家根旦有, 細井裕司
    • Organizer
      第18回国際癌増感研究会
    • Place of Presentation
      吹田市
    • Year and Date
      2012-06-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 超音波照射によるEGFRをターゲットにした分子標的治療Cetuximabの増感効果の検討2012

    • Author(s)
      太田一郎, 桝井貴史, 神野正敏, 家根旦有, 細井裕司
    • Organizer
      第36回日本頭頸部癌学会
    • Place of Presentation
      松江市
    • Year and Date
      2012-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 下咽頭癌におけるREG遺伝子ファミリーの発現と予後2012

    • Author(s)
      桝井貴史、太田一郎、高沢伸、細井裕司
    • Organizer
      第36回日本頭頸部癌学会
    • Place of Presentation
      松江市
    • Year and Date
      2012-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] がん研究UP TO DATE 2012世界の基礎研究の動向2012

    • Author(s)
      太田一郎
    • Organizer
      第6回頭頸部癌基礎研究会
    • Place of Presentation
      松江市
    • Year and Date
      2012-06-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Snail1 regulates MMP- dependent invasive activities through cancer cell EMT programs in head and neck cancer cells2012

    • Author(s)
      Ota I, Masui T, Yane K, Okamoto N, Hosoi H
    • Organizer
      the 14th Japan-Korea Joint Meeting of Otorhinolaryngology- Head and Neck Surgery
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Low-intensity ultrasound enhances anti-cancer effect of cetuximab on apoptosis induction in human head and neck cancer cells2012

    • Author(s)
      Masui T, Ota I, Kanno M, Hosoi H
    • Organizer
      the 14th Japan-Korea Joint Meeting of Otorhinolaryngology- Head and Neck Surgery
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Snail1 regulates MMP- dependent invasive activities through cancer cell EMT programs in head and neck cancer cells2012

    • Author(s)
      Ota I, Masui T, Yane K, Okamoto N, Hosoi H
    • Organizer
      8th International Conference on Head & Neck Cancer
    • Place of Presentation
      the Metro Toronto Convention , Centre in Toronto, Ontario, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] 1. Snail1 regulates MMP-dependent invasive activities through cancer cell EMT programs in head and neck cancer cells2012

    • Author(s)
      Ichiro Ota, Takashi Masui, Katsunari Yane, et al.
    • Organizer
      the 14th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Place of Presentation
      Kyoto, JAPAN
    • Related Report
      2012 Research-status Report
  • [Presentation] 3. Snail1 regulates MMP-dependent invasive activities through cancer cell EMT programs in head and neck cancer cells2012

    • Author(s)
      Ichiro Ota, Takashi Masui, Katsunari Yane, et al.
    • Organizer
      8th International Conference on Head & Neck Cancer
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2012 Research-status Report
  • [Presentation] 4. 超音波照射によるEGFRをターゲットにした分子標的治療Cetuximabの増感効果の検討2012

    • Author(s)
      太田一郎 桝井貴史 神野正敏ら
    • Organizer
      第36回 日本頭頸部癌学会
    • Place of Presentation
      松江市
    • Related Report
      2012 Research-status Report
  • [Presentation] Combination of cetuximab and low-intensity ultrasound causes a synergistic enhancement in cell killing and an additive enhancement in apoptosis induction in human head and neck cancer cells2011

    • Author(s)
      Masui T, Ota I, Kanno M, Hosoi H
    • Organizer
      The 11th Japan- Taiwan Conference on Otolaryngology- Head and Neck Surgery
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2011-12-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖尿病と癌の進展-高血糖は癌の浸潤を促進させる-

    • Author(s)
      太田一郎、桝井貴史、三上慎司、細井裕司
    • Organizer
      第114回日本耳鼻咽喉科学会総会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 下咽頭癌におけるREGIIIの発現と治療感受性

    • Author(s)
      桝井 貴史、太田 一郎、広中 安佐子ら
    • Organizer
      第37回日本頭頸部癌学会
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 頭頸部癌細胞におけるEGFRおよびmTORシグナル経路をターゲットにした分子標的治療

    • Author(s)
      太田一郎、他4名
    • Organizer
      第35回 日本頭頸部癌学会
    • Place of Presentation
      ウインクあいち、名古屋市
    • Related Report
      2011 Research-status Report
  • [Presentation] 頭頸部癌における分子標的治療

    • Author(s)
      太田一郎
    • Organizer
      第13回癌治療増感研究シンポジウム
    • Place of Presentation
      猿沢荘、奈良市
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.naramed-u.ac.jp/~oto/index.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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