Role of serine/arginine-rich protein kinase in the formation of choroidal neovascularization

• Project/Area Number: 23592547
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Hokkaido University
• Principal Investigator: SAITO Wataru 北海道大学, 医学(系)研究科(研究院), 特任准教授 (00339160)
• Co-Investigator(Kenkyū-buntansha): NODA Kousuke 北海道大学, 大学院医学研究科, 准教授 (90296666)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 眼細胞生物学 / 滲出型加齢黄斑編成 / 脈絡膜血管新生 / 血管内皮増殖因子 / SR蛋白質リン酸化酵素 / 滲出型加齢黄斑変性 / 加齢黄斑変性 / VEGF選択的スプライシング / SRPK

Research Abstract

Age-related macular degeneration (AMD) is a primary cause of visual loss in developed countries. Recent studies have provided strong evidence that growth factors and cytokines, such as vascular endothelial growth factor (VEGF), play a pivotal role in the process of pathological angiogenesis, choroidal neovascualization (CNV) in AMD. The alternative splicing of VEGF pre-mRNA is regulated by splicing regulatory factors including various serine/arginine-rich (SR) proteins, which are activated by SR protein kinase (SRPK). In this study, we elucidated that a specific inhibitor for SRPK, SRPIN340, attenuates CNV formation in laser-induced CNV model.

Research Products

• [Journal Article] Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization (2013)
  • Author(s): Dong Z,Noda K,Kanda A,Fukuhara J,Ando R,Murata M,Saito W,Hagiwara M,Ishida S
  • Journal Title: Mol Vis Volume: Vol. 19 Pages: 536-546
  • NAID: 120005372289
  • Peer Reviewed
• [Journal Article] Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization (2013)
  • Author(s): Dong Z, Noda K, Kanda A, Fukuhara J, Ando R, Murata M, Saito W, Hagiwara M, Ishida S
  • Journal Title: molecular vision Volume: 19 Pages: 536-543
  • NAID: 120005372289
  • Peer Reviewed
• [Presentation] Serine/arginine-rich protein Kinase Blockade attenuates choroidal neovascularization (2013)
  • Author(s): Dong Z,Noda K,Kanda A,Fukuhara J,Ando R,Murata M,Saito W,Hagiwara M,Ishida S
  • Organizer: ARVO (Association for Research in Vision and Ophthalmology) Annual Meeting
  • Place of Presentation: Washinton State Convention Center,Seattle,USA
• [Presentation] SRPK阻害薬による脈絡膜血管新生の抑制効果 (2013)
  • Author(s): 董震宇、野田航介、粛藤航、木下哲志、福原淳一、安藤亮、村田美幸、神田敦宏、萩原正敏、石田晋
  • Organizer: 第117回日本眼科学会総会
  • Place of Presentation: 東京、東京国際フォーラム、東京都千代田区
• [Presentation] SRPK阻害薬による脈絡膜血管新生の抑制効果 (2013)
  • Author(s): 董 震宇、野田航介、齋藤 航、木下哲志、福原淳一、安藤 亮、村田美幸、神田敦宏、萩原正敏、石田 晋
  • Organizer: 第117回 日本眼科学会
  • Place of Presentation: 東京国際フォーラム（東京都）
• [Presentation] Serine/Arginine-Rich Protein Kinase Blockade Attenuates Choroidal Neovascularization (2013)
  • Author(s): Zhenyu Dong, Kousuke Noda, Atsuhiro Kanda, Junichi Fukuhara, Ryo Ando, Miyuki Murata, Wataru Saito, Masatoshi Hagiwara, Susumu Ishida
  • Organizer: ARVO(Association for Research in Vision and Ophthalmology) Annual Meeting
  • Place of Presentation: Washington State Convention Center(米国）