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Characterization of CFP-expressed Vav-deficient mice with spontaneous IOP elevation to evaluate pressure-dependent RGC death

Research Project

Project/Area Number 23592549
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionHokkaido University

Principal Investigator

FUJIKAWA Keiko  北海道大学, 保健科学研究院, 客員研究員 (70374246)

Co-Investigator(Kenkyū-buntansha) INOUE Kaoru  北海道大学, 大学院保健科学研究院, 教授 (80133718)
ASAOKA Ryo  東京大学, 医学部付属病院, 講師 (00362202)
相原 一  北海道大学, その他の研究科, その他 (80222462)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords眼細胞生物学 / RGC障害評価動物モデル / 緑内障 / 疾患モデル動物 / 遺伝子 / シグナル伝達 / 脳神経疾患 / 脳・神経 / 神経科学 / 遺伝子改変動物
Research Abstract

It seems critically useful to develop the visible system how the retinal ganglion cells (RGCs) suffer from its damages and proceed into neuropathy under relative high intraocular pressures in vivo, although serious ocular disease like glaucoma, exists itself in optic neuropathy. Therefore we generate cyan fluorescein protein (CFP) expressed Vav2-deficient (CFP/Vav2) mice and Vav2, 3-deficient (CFP/Vav2, 3) mice respectively that only RGCs express CFP in those mice. First, we examined and proved that CFP/Vav2 mice system allows us to evaluate the RGCs damages quantitatively and paternally in vivo on the time course. This innovation is promising because the results obtained from RGCs examination are available for the neural cells of the brain.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (7 results)

All 2014 2013 Other

All Presentation (6 results) Remarks (1 results)

  • [Presentation] Vav2欠損CFP発現遺伝子改変マウスを用いた眼圧の影響とRGC障害の解析2014

    • Author(s)
      藤川恵子、井上馨、越山隆恵、山岸麗子、相原一
    • Organizer
      第118回日本眼科学会
    • Related Report
      2013 Final Research Report
  • [Presentation] Characterization of CFP-expressed Vav2-deficient mice with spontaneous2014

    • Author(s)
      Fujikawa K, Inoue K, Koshiyama T, Yamagishi R, Aihara M
    • Organizer
      IOP elevation to evaluate pressure-dependent RGC death
    • Place of Presentation
      ARVO, Orlando, FL, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Vav2 欠損CFP発現遺伝子改変マウスを用いた眼圧の影響とRGC障害の解析2014

    • Author(s)
      藤川恵子、井上馨、越山隆恵、山岸麗子、相原一
    • Organizer
      第118回日本眼科学会総会
    • Place of Presentation
      国際フォーラム、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Characterization of CFP-expressed Vav2-deficient mice with spontaneous IOP elevation to evaluate pressure-dependent RGC death2014

    • Author(s)
      Keiko Fujikawa, Kaoru Inoue, Takae Koshiyama, Reiko Yamagishi, Makoto Aihara
    • Organizer
      2014 ARVO meeting
    • Place of Presentation
      Orlando Convention Center, Orlando FL, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 自然発症高眼圧を呈するVav遺伝子欠損マウスの眼圧の特徴2013

    • Author(s)
      藤川恵子、井上馨、越山隆恵、山岸麗子、相原一
    • Organizer
      第117回日本眼科学会
    • Related Report
      2013 Final Research Report
  • [Presentation] 自然発症高眼圧を呈するVav遺伝子欠損マウスの眼圧の特徴2013

    • Author(s)
      藤川恵子、井上馨、越山隆恵、 相原一、山岸麗
    • Organizer
      日本眼科学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.ot-hokudai.info

    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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