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A chemokine receptor as a novel treatment target of age-related macular degeneration,

Research Project

Project/Area Number 23592552
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionThe University of Tokyo

Principal Investigator

YANAGI Yasuo  東京大学, 医学部附属病院, 講師 (90376442)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords加齢黄斑変性 / ケモカイン / CXCR3 / 脈絡膜新生血管
Research Abstract

This study investigated the effects of inflammatory cytokine, IP-10, on choroidal neovascularization due to age-related macular degeneration. The results demonstrated that IP-10 is produced in the inflammatory macrophage and retinal pigment epithelial cells and inhibits choroidal neovascularization through its receptor, CXCR3.
This study identified a new treatment target for age-related macular degeneration, a devastating condition leading to legal blindness.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (2 results)

All 2012

All Journal Article (2 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Angiostatic effect of CXCR3 expressed on choroidal neovascularization2012

    • Author(s)
      Fujimura S, Takahashi H, Yuda K, Ueta T, Iriyama A, Inoue T, Kaburaki T, Tamaki Y, Matsushima K, Yanagi Y
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 Pages: 1999-2006

    • Related Report
      2013 Final Research Report
  • [Journal Article] Effect of CXCR3 Expressed on Choroidal Neovascularization2012

    • Author(s)
      Fujimura S
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 Issue: 4 Pages: 1999-2006

    • DOI

      10.1167/iovs.11-8232

    • Related Report
      2011 Research-status Report
    • Peer Reviewed

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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