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The influence of unfolded protein response on age related macular degeneration.

Research Project

Project/Area Number 23592563
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionNagoya University

Principal Investigator

KACHI Shu  名古屋大学, 医学部附属病院, 講師 (30345904)

Co-Investigator(Kenkyū-buntansha) TERASAKI Hiroko  名古屋大学, 医学系研究科, 教授 (40207478)
KONDO Mineo  三重大学, 医学系研究科, 教授 (80303642)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords眼細胞生物学 / 小胞体ストレス / 網膜色素上皮 / 網膜 / RPE / 血管内皮増殖因子 / VEGF / 脈絡膜新生血管 / CNV
Research Abstract

Death of retinal pigment epitheial cells (RPE) and expression of vascular endotherial growth factor (VEGF) is the cause of age related macular degeneration (AMD). We have studied the influence of unfolded protein response (UPR) to these. When UPR occur in RPE, there was increase of factors that cause apopthosis. We have made lasere induced choroidal neovasularization (CNV) model mice, and comfermed that we could measure the size of CNV. The mice was oraly treated by drug which prevent UPR, however we could not detect the prevention of CNV.
Druzen is a precursor of AMD, and Amyloid beta is a component of the druzen. As amyloid beta cause expression of VEGF in RPE cells, we have bought caveolin 1 knockout mice which is known to cause amyloid beta deposit in the brain. We have found old mothers doesn't feed the babies, and need of the young mothers to increase the colony.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (40 results)

All 2014 2013 2012 2011 Other

All Journal Article (17 results) (of which Peer Reviewed: 16 results) Presentation (22 results) Book (1 results)

  • [Journal Article] Electroretinograms and level of aqueous vascular endothelial growth factor in eyes with hemicentral retinal vein occlusion or branch retinal vein occlusion2014

    • Author(s)
      Yasuda S, Kachi S, Ueno S, Ushida H, Piao CH, Kondo M, Terasaki H
    • Journal Title

      Jpn J Ophthalmol

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electroretinograms and level of aqueous vascular endothelial growth factor in eyes with hemicentral retinal vein occlusion or branch retinal vein occlusion.2014

    • Author(s)
      Yasuda S, Kachi S, Ueno S, Ushida H, Piao CH, Kondo M, Terasaki H.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-dependent alteration of intraocular soluble heparan sulfate levels and implication for proliferative diabetic retinopathy2013

    • Author(s)
      Nishiguchi KM, Ushida H, Tomida D, Kachi S, Kondo M, Terasaki H
    • Journal Title

      Molecular Vision

      Volume: 19 Pages: 1125-1131

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of preoperative intravitreous bevacizumab on visual function in eyes with proliferative diabetic retinopathy2013

    • Author(s)
      Ushida H, Kachi S, Asami T, Ishikawa K, Kondo M, Terasaki H
    • Journal Title

      Ophthalmic Research

      Volume: 43(1) Pages: 30-3

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-dependent alteration of intraocular soluble heparan sulfate levels and its implications for proliferative diabetic retinopathy.2013

    • Author(s)
      9. Nishiguchi KM, Ushida H, Tomida D, Kachi S, Kondo M, Terasaki H.
    • Journal Title

      Mol Vis.

      Volume: 19 Pages: 1125-1131

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Displacement of foveal area toward optic disc after macular hole surgery with internal limiting membrane peeling.2013

    • Author(s)
      11. Kawano K, Ito Y, Kondo M, Ishikawa K, Kachi S, Ueno S, Iguchi Y, Terasaki H.
    • Journal Title

      Eye

      Volume: 27 Pages: 871-877

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of preoperative intravitreous bevacizumab on visual function in eyes with proliferative diabetic retinopathy.2013

    • Author(s)
      Ushida H, Kachi S, Asami T, Ishikawa K, Kondo M, Terasaki H.
    • Journal Title

      Ophthalmic Research

      Volume: 43 Pages: 30-36

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Age-dependent alteration of intraocular soluble heparan sulfate levels and implication for proliferative diabetic retinopathy.2013

    • Author(s)
      Nishiguchi KM, Ushida H, Tomida D, Kachi S, Kondo M, Terasaki H.
    • Journal Title

      Molecular Vision

      Volume: 19

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Visual function 5 years or more after macular translocation surgery for myopic choroidal neovascularisation and age-related macular degeneration2012

    • Author(s)
      Takeuchi K, Kachi S, Iwata E, Ishikawa K, Terasaki H
    • Journal Title

      Eye (Lond)

      Volume: 26(1) Pages: 51-60

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 新生血管と遺伝子治療.2012

    • Author(s)
      加地 秀
    • Journal Title

      あたらしい眼科

      Volume: 29 Pages: 1107-1109

    • NAID

      10031120799

    • Related Report
      2012 Research-status Report
  • [Journal Article] Visual function 5 years or more after macular translocation surgery for myopic choroidal neovascularisation and age-related macular degeneration.2012

    • Author(s)
      Takeuchi K et al.
    • Journal Title

      Eye (Lond)

      Volume: 26 Pages: 51-60

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significant correlation between electroretinogram parameters and ocular vascular endothelial growth factor concentration in central retinal vein occlusion eyes2011

    • Author(s)
      Yasuda S, Kachi S, Kondo M, Ushida H, Uetani R, Terui T, Piao CH, Terasaki H
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52(8) Pages: 5737-5742

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of choroidal neovascularization and quantitative and qualitative inhibition of VEGF and CCL2 by heparin2011

    • Author(s)
      Tomida D, Nishiguchi KM, Kataoka K, Yasuma TR, Iwata E, Uetani R, Kachi S, Terasaki H
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52(6) Pages: 3193-3199

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The roles of vitreal macrophages and circulating leukocytes in retinal neovascularization2011

    • Author(s)
      Kataoka K, Nishiguchi KM, Kaneko H, van Rooijen N, Kachi S, Terasaki H
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52(3) Pages: 1431-1438

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significant correlation between electroretinogram parameters and ocular vascular endothelial growth factor concentration in central retinal vein occlusion eyes.2011

    • Author(s)
      Yasuda S et al.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 52 Pages: 5737-5742

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rebound of macular edema after intravitreal bevacizumab therapy in eyes with macular edema secondary to branch retinal vein occlusion.2011

    • Author(s)
      Yasuda S et al.
    • Journal Title

      Retina

      Volume: 31 Pages: 1075-1082

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Suppression of choroidal neovascularization and quantitative and qualitative inhibition of VEGF and CCL2 by heparin.2011

    • Author(s)
      Tomida D et al.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 52 Pages: 3193-3199

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Electronretinogram and aqueous vascular endotheril growth factor in the eyes with hemi-central retinal vein occlusion or branch retinal vein occlusion2013

    • Author(s)
      Kachi S, Yasuda S, Ushida H, Kondo M, Ueno S, Piao C, Terasaki H
    • Organizer
      ARVO Annual Meeting
    • Place of Presentation
      Seattle, USA(ポスター)
    • Year and Date
      2013-05-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Anti-histamine receptor 4 therapy inhibits choroidal neovascularization in mice2013

    • Author(s)
      Kaneko H, Ijima R, Kachi S, Terasaki H
    • Organizer
      ARVO Annual Meeting
    • Place of Presentation
      Seattle, USA(ポスター)
    • Related Report
      2013 Final Research Report
  • [Presentation] Interleukin-18 induced retinal pigment eithelium cell death, but did not suppress choroidal neovascularization in mice2013

    • Author(s)
      Ijima R, Kaneko H, Kachi S, Terasaki H
    • Organizer
      ARVO Annual Meeting
    • Place of Presentation
      Seattle, USA(ポスター)
    • Related Report
      2013 Final Research Report
  • [Presentation] Changes in implicit times of 30Hz Flicker Electroretinograms after photocoagulation in eyes with central retinal vein occlusion2012

    • Author(s)
      Kachi S, Yasuda S, Ushida H, Uetani R, Kondo M, Terasaki H
    • Organizer
      ARVO Annual Meeting
    • Place of Presentation
      Fort Lauderdale, USA(ポスター)
    • Year and Date
      2012-05-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Changes In Implicit Times of 30 Hz Flicker Electroretinograms After Photocoagulation In Eyes With Central Retinal Vein Occlusion.2012

    • Author(s)
      Kachi S, Yasuda S, Ushida H, Uetani R, Kondo M, Terasaki H.
    • Organizer
      Annual Meeting for Association of Research for Vision and Ophthalmology
    • Place of Presentation
      Floirda, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 緑内障術後3ヶ月の眼圧変化と脈絡膜厚変化、眼軸長変化との関係2012

    • Author(s)
      長屋佐千子 植谷留佳 加地秀 長屋匡俊 伊島亮 伊藤逸毅 寺崎浩子
    • Organizer
      日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム、東京都
    • Related Report
      2012 Research-status Report
  • [Presentation] 網膜静脈分枝閉塞と半側網膜中心静脈閉塞における眼内血管内皮増殖因子濃度と網膜電図2012

    • Author(s)
      安田俊介 加地 秀 上野真治 近藤峰生 牛田宏昭  植谷留佳  朴昌華  寺崎浩子
    • Organizer
      日本臨床視覚電気生理学会
    • Place of Presentation
      ミッドランドホール、名古屋市
    • Related Report
      2012 Research-status Report
  • [Presentation] 糖尿病黄斑浮腫に対する抗VEGF 療法の中心窩網膜厚と網膜電図の関係2012

    • Author(s)
      牛田宏昭 加地 秀 杉田 糾 安田俊介  朴昌華   寺崎浩子
    • Organizer
      日本糖尿病眼学会
    • Place of Presentation
      アクロス福岡、福岡市
    • Related Report
      2012 Research-status Report
  • [Presentation] Unfolded Protein Response is Associated with Expression of Vascular Endothelial Growth Factor by Retinal Pigment Epithelial Cells2011

    • Author(s)
      Kachi S et al.
    • Organizer
      ARVO annual meeting
    • Place of Presentation
      フォートローダーデール(米国)
    • Related Report
      2011 Research-status Report
  • [Presentation] Correlations Between The VEGF Levels In Aqueous Humor And Amplitudes And Implicit Times Of Different Components of Electroretinogram In Eyes With CRVO.2011

    • Author(s)
      Yasuda S et al.
    • Organizer
      ARVO annual meeting
    • Place of Presentation
      フォートローダーデール(米国)
    • Related Report
      2011 Research-status Report
  • [Presentation] 内境界膜剥離併用黄斑円孔手術後の黄斑部網膜の移動2011

    • Author(s)
      川野健一ら
    • Organizer
      日本臨床眼科学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 網膜中心静脈閉塞症に対する光凝固の網膜電図への影響2011

    • Author(s)
      加地秀ら
    • Organizer
      日本網膜硝子体学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 緑内障手術による眼圧変化に伴う脈絡膜厚と眼軸長の変化2011

    • Author(s)
      植谷留佳ら
    • Organizer
      日本網膜硝子体学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] Anti-histamine receptor 4 therapy inhibits choroidal neovascularization in mice.

    • Author(s)
      Kaheko H, Ijima R, Kachi S, Terasaki H.
    • Organizer
      ARVO annual meeting
    • Place of Presentation
      シアトル(米国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Interleukin-18 induced retinal pigment eithelium cell death, but did not suppress choroidal neovascularization in mice.

    • Author(s)
      Ijima R, Kaneko H, Kachi S, Terasaki H.
    • Organizer
      ARVO annual meeting
    • Place of Presentation
      シアトル(米国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Fine analysis of the deletions in red/green opsin genes and the upstream locus control region(LCR) found in two Japanese families with blue cone monochromacy(BCM).

    • Author(s)
      Wang CX, Hosono K, Kachi S, Terasaki H, Hotta Y, Minoshima S.
    • Organizer
      ARVO annual meeting
    • Place of Presentation
      シアトル(米国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Spectral-domain optical coherence tomographic findings in acute zonal occult outer retinopathy(AZOOR)-complex at initial visit to the hospital.

    • Author(s)
      Matsui Y, MiyataM, Matsubara H, Ueno S, Kachi S, Ito Y, Terasaki H, Kondo M.
    • Organizer
      ARVO annual meeting
    • Place of Presentation
      シアトル(米国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Electronretinogram and aqueous vascular endotheril growth factor in the eyes with hemi-central retinal vein occlusion or branch retinal vein occlusion.

    • Author(s)
      Kachi S, Yasuda S, Ushida H, Kondo M, Ueno S, Piao C, Terasaki H.
    • Organizer
      ARVO annual meeting
    • Place of Presentation
      シアトル(米国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 緑内障白内障同時手術後の屈折誤差

    • Author(s)
      恒川明季 ら
    • Organizer
      鶴舞オフサルミックセミナー
    • Place of Presentation
      東急ホテル(名古屋市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 黄斑上膜、黄斑円孔の内境界膜剥離前後の術中hand-held OCTによる層別解析

    • Author(s)
      浅見哲、伊藤逸毅、二村裕紀子、中西絢美、岩瀬剛、上野真治、加地秀、寺崎浩子
    • Organizer
      日本臨床眼科学会
    • Place of Presentation
      国立横浜国際会議場(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] AZOOR complexの発症から6か月刊のSD-OCT所見の変化

    • Author(s)
      松井良諭、松原央、宮田良平、上野真治、加地秀、伊藤逸毅、寺崎浩子、近藤峰生
    • Organizer
      日本臨床眼科学会
    • Place of Presentation
      国立横浜国際会議場(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 半側網膜中心静脈閉塞と網膜静脈分枝閉塞黄斑浮腫、網膜機能と眼内血管内皮増殖因子

    • Author(s)
      加地秀、安田俊介、牛田宏昭、上野真治、近藤峰生、伊藤逸毅、寺崎浩子
    • Organizer
      日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Related Report
      2013 Annual Research Report
  • [Book] 新生血管と遺伝子治療.あたらしい眼科(第29巻8号)2012

    • Author(s)
      加地秀ら
    • Publisher
      メディカル葵出版
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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