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Analysis of retinal nerve fiber bundle damages in glaucoma by using adaptive optics laser scanning ophthalmoscope

Research Project

Project/Area Number 23592565
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionSaitama Medical University (2013)
Kyoto University (2011-2012)

Principal Investigator

HANGAI Masanori  埼玉医科大学, 医学部, 教授 (70283687)

Co-Investigator(Kenkyū-buntansha) OOTO Sotaro  京都大学, 医学(系)研究科(研究院), 助教 (10511850)
NONAKA Atsushi  京都大学, 医学(系)研究科(研究院), 助教 (40532601)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords緑内障 / 補償光学 / イメージング / 網膜神経線維束 / 神経節細胞 / 補償光学レーザー走査検眼鏡 / 網膜神経線維
Research Abstract

We showed that adaptive optics scanning laser ophthalmoscope (AO-SLO) we originally developed enables clear visualization of the retinal nerve fiber bundles. Retinal nerve fiber bundles seen on AO-SLO revealed structural characteristics of retinal nerve fiber bundles in normal eyes. AL-SLO allowed reproducible measurement of retinal nerve fiber bundle width. Based on this normal findings, we demonstrated that retinal nerve fiber bundles are significantly narrower in glaucomatous eyes than in normal eyes. This abnormality in retinal nerve fiber bundles was associated with visual field sensitivity decrease in cluster. Our report of these findings are the first one as far as we are aware. Our study suggested that AO-SLO is able to analyze the retinal nerve fiber bundle width that no other technologies could not. Thus, retinal nerve fiber bundle imaging on AO-SLO may open a new avenue for glaucoma diagnosis based on 3-dimensional analysis of internal structure of retinal nerve fiber layer.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (12 results)

All 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (9 results) (of which Invited: 5 results)

  • [Journal Article] High-resolution imaging of retinal nerve fiber bundles in glaucoma using adaptive optics scanning laser ophthalmoscopy2013

    • Author(s)
      Takayama K, Ooto S, Hangai M, Ueda-Arakawa N, Yoshida S, Akagi T, Ikeda HO, Nonaka A, Hanebuchi M, Inoue T, Yoshimura N
    • Journal Title

      Am J Ophthalmol

      Volume: 155(5) Issue: 5 Pages: 870-81

    • DOI

      10.1016/j.ajo.2012.11.016

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] High-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy2012

    • Author(s)
      Takayama K, Ooto S, Hangai M, Arakawa N, Oshima S, Shibata N, Hanebuchi M, Inoue T, Yoshimura N
    • Journal Title

      PLoS One

      Volume: 7(3) Issue: 3 Pages: e33158-e33158

    • DOI

      10.1371/journal.pone.0033158

    • NAID

      120003988392

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] High-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy.2012

    • Author(s)
      Takayama K, Ooto S, Hangai M, Arakawa N, Oshima S, Shibata N, Hanebuchi M, Inoue T, Yoshimura N
    • Journal Title

      PLoS One

      Volume: 7

    • NAID

      120003988392

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Adaptive Optics SLOによる網膜神経線維束の可視化シンポジウム【最新緑内障検査機器のアップデート】2014

    • Author(s)
      大音壯太郞
    • Organizer
      日本眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Adaptive Optics in Glaucoma2014

    • Author(s)
      Sotaro Ooto
    • Organizer
      World Ophthalmology Congress
    • Place of Presentation
      東京(Symposium)
    • Related Report
      2013 Final Research Report
  • [Presentation] Adaptive optics and optical coherence tomography2014

    • Author(s)
      Masanori Hangai
    • Organizer
      World Ophthalmology Congress
    • Place of Presentation
      東京(Symposium)
    • Related Report
      2013 Final Research Report
  • [Presentation] Adaptive Optics SLOによる網膜神経線維束の可視化2014

    • Author(s)
      大音壮太郎
    • Organizer
      日本眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Adaptive Optics in Glaucoma2014

    • Author(s)
      大音壮太郎
    • Organizer
      Would Glaucoma Conference
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Adaptive Optics and Optical Coherence Tomography2014

    • Author(s)
      板谷正紀
    • Organizer
      Would Glaucoma Conference
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 補償光学走査型レーザー検眼鏡を用いた緑内障眼における網膜神経線維束の高解像度イメージングシンポジウム2013

    • Author(s)
      高山弘平、大音壮太郎、板谷正紀、赤木忠通、池田華子、吉村長久
    • Organizer
      日本緑内障学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Structural assessment beyond the optic disc2012

    • Author(s)
      Hangai M
    • Organizer
      The 27th APAO (Asia Pacific Academy of Ophthalmology) Congress
    • Place of Presentation
      Busan, Korea
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] High-resolution imaging of the RNFL, choroid and lamina2012

    • Author(s)
      Hangai M
    • Organizer
      The 1st Asia-Pacific Glaucoma Congress
    • Place of Presentation
      Bali, Indonesia
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2011-08-05   Modified: 2019-07-29  

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