Analysis of retinal nerve fiber bundle damages in glaucoma by using adaptive optics laser scanning ophthalmoscope
Project/Area Number |
23592565
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | Saitama Medical University (2013) Kyoto University (2011-2012) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
OOTO Sotaro 京都大学, 医学(系)研究科(研究院), 助教 (10511850)
NONAKA Atsushi 京都大学, 医学(系)研究科(研究院), 助教 (40532601)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 緑内障 / 補償光学 / イメージング / 網膜神経線維束 / 神経節細胞 / 補償光学レーザー走査検眼鏡 / 網膜神経線維 |
Research Abstract |
We showed that adaptive optics scanning laser ophthalmoscope (AO-SLO) we originally developed enables clear visualization of the retinal nerve fiber bundles. Retinal nerve fiber bundles seen on AO-SLO revealed structural characteristics of retinal nerve fiber bundles in normal eyes. AL-SLO allowed reproducible measurement of retinal nerve fiber bundle width. Based on this normal findings, we demonstrated that retinal nerve fiber bundles are significantly narrower in glaucomatous eyes than in normal eyes. This abnormality in retinal nerve fiber bundles was associated with visual field sensitivity decrease in cluster. Our report of these findings are the first one as far as we are aware. Our study suggested that AO-SLO is able to analyze the retinal nerve fiber bundle width that no other technologies could not. Thus, retinal nerve fiber bundle imaging on AO-SLO may open a new avenue for glaucoma diagnosis based on 3-dimensional analysis of internal structure of retinal nerve fiber layer.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] High-resolution imaging of retinal nerve fiber bundles in glaucoma using adaptive optics scanning laser ophthalmoscopy2013
Author(s)
Takayama K, Ooto S, Hangai M, Ueda-Arakawa N, Yoshida S, Akagi T, Ikeda HO, Nonaka A, Hanebuchi M, Inoue T, Yoshimura N
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Journal Title
Am J Ophthalmol
Volume: 155(5)
Issue: 5
Pages: 870-81
DOI
Related Report
Peer Reviewed
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