| Project/Area Number |
23592566
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
IKUNO Yasushi 大阪大学, 医学(系)研究科(研究院), 講師 (50294096)
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| Co-Investigator(Kenkyū-buntansha) |
谷山 義明 , 医学系研究科, 准教授 (60372611)
五味 文 , 医学系研究科, 研究員 (80335364)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ペリオスチン / 加齢黄斑変性 / 網膜 / 眼科 / 脈絡膜新生血管 / 脈絡膜 / 糖尿病網膜症 / 緑内障 |
|---|
| Research Abstract |
Choroidal neovascularization model was established in mouse model, and the mRNA expression of periostin that regulates the extra-cellular matrix was investigated using polymerase chain reaction. Soon after induction, the periostin expression was slowly up-regulated, and maintained for 28 days. While tumor necrosis factor-alpha, which was used for control, showed an acute increase. This data indicates that periostin is specifically introduced by choroidal neovascularization, and prevention of periostin expression can be an preventive treatment for such conditions as age-related macular degeneration.
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