Identification and the use of phenotype specific polymorphism for personalized medicine in age-related macular degeneration

• Project/Area Number: 23592567
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kobe University
• Principal Investigator: HONDA Shigeru 神戸大学, 医学(系)研究科(研究院), 講師 (60283892)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 加齢黄斑変性 / 遺伝子多型 / 個別化医療 / ゲノム関連解析

Research Abstract

We investigate the association of ARMS2/HTRA1, CFH, CD36, elastin gene polymorphism with typical age-related macular degeneration (tAMD) and polypoidal choroidal vasculopathy (PCV). We found different associations of elastin and CD36 variants between tAMD and PCV. We evaluated the factors responsible for the effect of photodynamic therapy (PDT) and anti-vascular endothelial growth factor (VEGF) therapy on AMD, and found that AMD subtypes as well as the genetic variants of ARMS2/HTRA1, CFH, CD36 influence the outcome of therapies.

Research Products

• [Journal Article] Evaluation of clinical and genetic indicators for the early response to intravitreal ranibizumab in exudative age-related macular degeneration (2014)
  • Author(s): Matsumiya W, Honda S, Yanagisawa S, Miki A, Nagai T, Tsukahara Y
  • Journal Title: Pharmacogenomics Volume: 15 Pages: 833-43
  • Peer Reviewed
• [Journal Article] LAPTOP Study : A 24-Month Trial of Verteporfin Versus Ranibizumab for Polypoidal Choroidal Vasculopathy (2014)
  • Author(s): Oishi A, Miyamoto N, Mandai M, Honda S, Matsuoka T, Oh H, Kita M, Nagai T, Bessho N, Uenishi M, Kurimoto Y, Negi A
  • Journal Title: Ophthalmology Volume: 121 Pages: 1151-2
  • Peer Reviewed
• [Journal Article] Common Variants in the Complement Factor H Gene Confer Genetic Susceptibility to Central Serous Chorioretinopathy (2014)
  • Author(s): Miki A, Kondo N, Yanagisawa S, Bessho H, Honda S, Negi A
  • Journal Title: Ophthalmology Volume: 121 Pages: 1067-72
  • Peer Reviewed
• [Journal Article] Evaluation of clinical and genetic indicators for the early response to intravitreal ranibizumab in exudative age-related macular degeneration. (2014)
  • Author(s): Matsumiya W, Honda S, Yanagisawa S, Miki A, Nagai T, Tsukahara Y.
  • Journal Title: Pharmacogenomics Volume: 未定
  • Peer Reviewed
• [Journal Article] Comparison of the outcomes of photodynamic therapy between two angiographic subtypes of polypoidal choroidal vasculopathy (2014)
  • Author(s): Honda S, Miki A, Yanagisawa S, Matsumiya W, Nagai T, Tsukahara Y.
  • Journal Title: Ophthalmologica Volume: 未定
  • Peer Reviewed
• [Journal Article] Common Variants in the Complement Factor H Gene Confer Genetic Susceptibility to Central Serous Chorioretinopathy. (2014)
  • Author(s): Miki A, Kondo N, Yanagisawa S, Bessho H, Honda S, Negi A.
  • Journal Title: Ophthalmology Volume: 未定 Issue: 5 Pages: 1067-1072
  • DOI: 10.1016/j.ophtha.2013.11.020
  • Peer Reviewed
• [Journal Article] Comparison of the Effect of Ranibizumab and Verteporfin for Polypoidal Choroidal Vasculopathy : 12-Month LAPTOP Study Results (2013)
  • Author(s): Oishi A, Kojima H, Mandai M, Honda S, Matsuoka T, Oh H, Kita M, Nagai T, Fujihara M, Bessho N, Uenishi M, Kurimoto Y, Negi A
  • Journal Title: Am J Ophthalmol Volume: 156 Pages: 644-51
  • Peer Reviewed
• [Journal Article] Severe retinopathy of prematurity with retinal detachment in monozygotic twins (2013)
  • Author(s): Fujioka K, Morioka I, Honda S, Tsukahara Y, Miwa A, Shibata A, Tanimura K, Yokoyama N, Yamada H, Iijima K
  • Journal Title: Pediatr Int Volume: 55 Pages: 366-8
  • Peer Reviewed
• [Journal Article] The effects of oral bisphosphonates on myopic choroidal neovascularization over 2 years of follow-up : a pilot study comparing with anti-VEGF therapy and photodynamic therapy (2013)
  • Author(s): Miki A, Honda S, Nagai T, Tsukahara Y, Negi A
  • Journal Title: Br J Ophthalmol Volume: 97 Pages: 770-4
  • Peer Reviewed
• [Journal Article] Effectiveness of intravitreal ranibizumab in exudative age-related macular degeneration (AMD): comparison between typical neovascular AMD and polypoidal choroidal vasculopathy over a 1 year follow-up (2013)
  • Author(s): Matsumiya W, Honda S, Kusuhara S, Tsukahara Y, Negi A
  • Journal Title: BMC Ophthalmol Volume: 13 Pages: 10-10
  • NAID: 120005627290
  • Peer Reviewed
• [Journal Article] The visual outcome of photodynamic therapy for typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy over 5 years of follow-up (2013)
  • Author(s): Miki A, Honda S, Kojima H, Nishizaki M, Nagai T, Fujihara M, Uenishi M, Kita M, Negi A
  • Journal Title: Jpn J Ophthalmol Volume: 57 Pages: 301-7
  • NAID: 10031176286
  • Peer Reviewed
• [Journal Article] Predictive value of preoperative optical coherence tomography for visual outcome following macular hole surgery : effects of imaging alignment (2013)
  • Author(s): Matsumiya W, Kusuhara S, Shimoyama T, Honda S, Tsukahara Y, Negi A
  • Journal Title: Jpn J Ophthalmol Volume: 57 Pages: 308-15
  • NAID: 10031176287
  • Peer Reviewed
• [Journal Article] The association of age-related maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH) variants with two angiographic subtypes of polypoidal choroidal vasculopathy (2013)
  • Author(s): Miki A, Honda S, Kondo N, Negi A
  • Journal Title: Ophthalmic Genet Volume: 34 Pages: 146-50
  • Peer Reviewed
• [Journal Article] Visual outcome of photodynamic therapy for typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy over 5 years of follow-up. (2013)
  • Author(s): Miki A, Honda S, Kojima H, Nishizaki M, Nagai T, Fujihara M, Uenishi M, Kita M, Kurimoto Y, Negi A; Hyogo Macular Disease Study Group.
  • Journal Title: Jpn J Ophthalmol. Volume: 未定 Issue: 3 Pages: 146-150
  • DOI: 10.1007/s10384-013-0237-9
  • NAID: 10031176286
  • Peer Reviewed
• [Journal Article] Comparison of the Effect of Ranibizumab and Verteporfin for Polypoidal Choroidal Vasculopathy: 12-Month LAPTOP Study Results (2013)
  • Author(s): Oishi A, Kojima H, Mandai M, Honda S, Matsuoka T, Oh H, Kita M, Nagai T, Fujihara M, Bessho N, Uenishi M, Kurimoto Y, Negi A.
  • Journal Title: Am J Ophthalmol. Volume: 156 Issue: 4 Pages: 644-651
  • DOI: 10.1016/j.ajo.2013.05.024
  • Peer Reviewed
• [Journal Article] Effects of oral bisphosphonates on myopic choroidal neovascularisation over 2 years of follow-up: comparison with anti-VEGF therapy and photodynamic therapy. A pilot study. (2013)
  • Author(s): Miki A, Honda S, Nagai T, Tsukahara Y, Negi A.
  • Journal Title: Br J Ophthalmol. Volume: 97 Issue: 6 Pages: 770-774
  • DOI: 10.1136/bjophthalmol-2012-303007
  • Peer Reviewed
• [Journal Article] Effectiveness of intravitreal ranibizumab in exudative age-related macular degeneration (AMD): comparison between typical neovascular AMD and polypoidal choroidal vasculopathy over a 1 year follow-up. (2013)
  • Author(s): Matsumiya W, Honda S, Kusuhara S, Tsukahara Y, Negi A.
  • Journal Title: BMC Ophthalmol. Volume: 13 Issue: 1 Pages: 10-10
  • DOI: 10.1186/1471-2415-13-10
  • NAID: 120005627290
  • Peer Reviewed
• [Journal Article] Predictive value of preoperative optical coherence tomography for visual outcome following macular hole surgery: effects of imaging alignment. (2013)
  • Author(s): Matsumiya W, Kusuhara S, Shimoyama T, Honda S, Tsukahara Y, Negi A.
  • Journal Title: Jpn J Ophthalmol. Volume: 未定 Issue: 3 Pages: 308-315
  • DOI: 10.1007/s10384-013-0232-1
  • NAID: 10031176287
  • Peer Reviewed
• [Journal Article] The Association of Age-related Maculopathy Susceptibility 2 (ARMS2) and Complement Factor H (CFH) Variants with Two Angiographic Subtypes of Polypoidal Choroidal Vasculopathy. (2013)
  • Author(s): Miki A, Honda S, Kondo N, Negi A.
  • Journal Title: Ophthalmic Genet. Volume: 未定 Issue: 3 Pages: 146-150
  • DOI: 10.3109/13816810.2012.749288
  • Peer Reviewed
• [Journal Article] Positive association of CD36 gene variants with the visual outcome of photodynamic therapy in polypoidal choroidal vasculopathy (2012)
  • Author(s): Honda S, Bessho H, Kondo N, Kusuhara S, Tsukahara Y, Negi A
  • Journal Title: Mol Vis Volume: 18 Pages: 2796-804
  • Peer Reviewed
• [Journal Article] Recurrence of macular hole retinal detachment after intravitreal ranibizumab injection for the treatment of choroidal neovascularization from the remaining macular hole edge (2012)
  • Author(s): Otsuka K, Imai H, Shimoyama T, Nagai T, Honda S, Azumi A
  • Journal Title: Case Report Ophthalmol Volume: 3 Pages: 424-7
  • NAID: 120005702371
  • Peer Reviewed
• [Journal Article] Comparison of the effect between pegaptanib and ranibizumab on exudative age-related macular degeneration with small lesion size (2012)
  • Author(s): Nishimura Y, Taguchi M, Nagai T, Fujihara M, Honda S, Uenishi M
  • Journal Title: Clin Ophthalmol Volume: 6 Pages: 365-8
  • Peer Reviewed
• [Journal Article] Effect of photodynamic therapy (PDT), posterior subtenon injection of triamcinolone acetonide with PDT, and intravitreal injection of ranibizumab with PDT for retinal angiomatous proliferation (2012)
  • Author(s): Nakano S, Honda S, Oh H, Kita M, Negi A
  • Journal Title: Clin Ophthalmol Volume: 6 Pages: 277-82
  • Peer Reviewed
• [Journal Article] The association of CD36 variants with polypoidal choroidal vasculopathy compared to typical neovascular age-related macular degeneration (2012)
  • Author(s): Bessho H, Honda S, Kondo N, Kusuhara S, Tsukahara Y, Negi A
  • Journal Title: Mol Vis Volume: 18 Pages: 121-7
  • Peer Reviewed
• [Journal Article] Comparison between anti-vascular endothelial growth factor therapy and photodynamic therapy for myopic choroidal neovascularization (2012)
  • Author(s): Matsuo M, Honda S, Matsumiya W, Kusuhara S, Tsukahara Y, Negi A
  • Journal Title: Eur J Ophthalmol Volume: 22 Pages: 210-5
  • Peer Reviewed
• [Journal Article] Positive association of CD36 gene variants with the visual outcome of photodynamic therapy in polypoidal choroidal vasculopathy. (2012)
  • Author(s): Honda S, Bessho H, Kondo N, Kusuhara S, Tsukahara Y, Negi A.
  • Journal Title: Mol Vis. Volume: 18 Pages: 2796-804
  • Peer Reviewed
• [Journal Article] Recurrence of macular hole retinal detachment after intravitreal ranibizumab injection for the treatment of choroidal neovascularization from the remaining macular hole edge. (2012)
  • Author(s): Otsuka K, Imai H, Shimoyama T, Nagai T, Honda S, Azumi A.
  • Journal Title: Case Rep Ophthalmol. Volume: 3 Issue: 3 Pages: 424-7
  • DOI: 10.1159/000346041
  • NAID: 120005702371
  • Peer Reviewed
• [Journal Article] Effect of photodynamic therapy (PDT), posterior subtenon injection of triamcinolone acetonide with PDT, and intravitreal injection of ranibizumab with PDT for retinal angiomatous proliferation. (2012)
  • Author(s): Nakano S, Honda S, Oh H, Kita M, Negi A.
  • Journal Title: Clin Ophthalmol. Volume: 6 Pages: 277-282
  • DOI: 10.2147/opth.s29718
  • Peer Reviewed
• [Journal Article] Comparison of the effect between pegaptanib and ranibizumab on exudative age-related macular degeneration with small lesion size. (2012)
  • Author(s): Nishimura Y, Taguchi M, Nagai T, Fujihara M, Honda S, Uenishi M.
  • Journal Title: Clin Ophthalmol. Volume: 6 Pages: 365-368
  • DOI: 10.2147/opth.s30310
  • Peer Reviewed
• [Journal Article] The association of CD36 variants with polypoidal choroidal vasculopathy compared to typical neovascular age-related macular degeneration. (2012)
  • Author(s): Bessho H, Honda S, Kondo N, Kusuhara S, Tsukahara Y, Negi A.
  • Journal Title: Mol Vis. Volume: 18 Pages: 121-127
  • Peer Reviewed
• [Journal Article] Difference between age-related macular degeneration and polypoidal choroidal vasculopathy in the hereditary contribution of the A69S variant of the age-related maculopathy susceptibility 2 gene (ARMS2) (2011)
  • Author(s): Yanagisawa S, Kondo N, Miki A, Matsumiya W, Kusuhara S, Tsukahara Y, Honda S, Negi A
  • Journal Title: Mol Vis Volume: 17 Pages: 3574-82
  • Peer Reviewed
• [Journal Article] A Common Complement C3 Variant Is Associated with Protection against Wet Age-Related Macular Degeneration in a Japanese Population (2011)
  • Author(s): Yanagisawa S, Kondo N, Miki A, Matsumiya W, Kusuhara S, Tsukahara Y, Honda S, Negi A
  • Journal Title: PLoS One Volume: 6
  • Peer Reviewed
• [Journal Article] Macular edema formation and deterioration of retinal function after intravitreal bevacizumab injection for proliferative diabetic retinopathy (2011)
  • Author(s): Imai H, Honda S, Tsukahara Y, Negi A
  • Journal Title: Case Report Ophthalmol Volume: 2 Pages: 314-8
  • NAID: 120005702372
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population (2011)
  • Author(s): Arakawa S, Takahashi A, Ashikawa K, Hosono N, Aoi T, Yasuda M, Oshima Y, Yoshida S, Enaida H, Tsuchihashi T, Mori K, Honda S, Negi A, Arakawa A, Kadonosono K, Kiyohara Y, Kamatani N, Nakamura Y, Ishibashi T, Kubo M
  • Journal Title: Nat Genet Volume: 43 Pages: 1001-4
  • Peer Reviewed
• [Journal Article] A surviving case of papillorenal syndrome with the phenotype of Potter sequence (2011)
  • Author(s): Fujioka K, Morioka I, Nozu K, Nishimoto M, Amano M, Tagami M, Honda S, Yokoyama N, Yamada H, Iijima K, Matsuo M
  • Journal Title: Pediatr Int Volume: 53 Pages: 406-8
  • NAID: 10029558611
  • Peer Reviewed
• [Journal Article] Early responses to intravitreal ranibizumab in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy (2011)
  • Author(s): Matsumiya W, Honda S, Bessho H, Kusuhara S, Tsukahara Y, Negi A
  • Journal Title: J Ophthalmol Volume: (ID 742020)
  • Peer Reviewed
• [Journal Article] Impact of Intravitreal Injection of Tissue Plasminogen Activator on Full-Field Electroretinogram in Patients with Macular Oedema Secondary to Retinal Vein Occlusion (2011)
  • Author(s): Tagami M, Kusuhara S, Imai H, Honda S, Tsukahara Y, Negi A
  • Journal Title: Ophthalmologica Volume: 226 Pages: 81-86
  • Peer Reviewed
• [Journal Article] The association of ARMS2 polymorphisms with phenotype in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy (2011)
  • Author(s): Bessho H, Honda S, Kondo N, Negi A
  • Journal Title: Mol Vis Volume: 17 Pages: 977-982
  • Peer Reviewed
• [Journal Article] VEGF 936C>T is predictive of threshold retinopathy of prematurity in Japanese infants with a 30-week gestational age or less (2011)
  • Author(s): Yagi M, Yamamori M, Morioka I, Yokoyama N, Honda S,, Negi A, Nakamura T, Okamura N, Okumura K, Sakaeda T, Matsuo M
  • Journal Title: Research and Reports in Neonatology Volume: 1 Pages: 5-11
  • Peer Reviewed
• [Journal Article] Positive association of complement factor H gene variants with the effect of photodynamic therapy in polypoidal choroidal vasculopathy (2011)
  • Author(s): Bessho H, Honda S, Kondo N, et al
  • Journal Title: J Clinic Experiment Ophthalmol Volume: 2 Pages: 122-122
  • Peer Reviewed
• [Journal Article] Natural course and funduscopic findings of polypoidal choroidal vasculopathy in a Japanese population over one year of follow-up (2011)
  • Author(s): Bessho H, Honda S, Imai H, Negi A
  • Journal Title: Retina Volume: 31 Pages: 1598-602
  • Peer Reviewed
• [Journal Article] Complement Factor H Y402H Variant and Risk of Age-Related Macular Degeneration in Asians : A Systematic Review and Meta-Analysis (2011)
  • Author(s): Kondo N, Bessho H, Honda S, Negi A
  • Journal Title: Ophthalmology Volume: 188 Pages: 339-44
  • Peer Reviewed
• [Journal Article] Difference between age-related macular degeneration and polypoidal choroidal vasculopathy in the hereditary contribution of the A69S variant of the age-related maculopathy susceptibility 2 gene (ARMS2). (2011)
  • Author(s): Yanagisawa S, Kondo N, Miki A, Matsumiya W, Kusuhara S, Tsukahara Y, Honda S, Negi A.
  • Journal Title: Mol Vis. Volume: 17 Pages: 3574-3582
  • Peer Reviewed
• [Journal Article] A Common Complement C3 Variant Is Associated with Protection against Wet Age-Related Macular Degeneration in a Japanese Population. (2011)
  • Author(s): Yanagisawa S, Kondo N, Miki A, Matsumiya W, Kusuhara S, Tsukahara Y, Honda S, Negi A.
  • Journal Title: PLoS One Volume: 6 Issue: 12 Pages: e28847-e28847
  • DOI: 10.1371/journal.pone.0028847
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population (2011)
  • Author(s): Arakawa, S., et.al.
  • Journal Title: Nat Genet Volume: 43(10) Issue: 10 Pages: 1001-4
  • DOI: 10.1038/ng.938
  • Peer Reviewed
• [Journal Article] Early responses to intravitreal ranibizumab in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. (2011)
  • Author(s): Matsumiya W, Honda S, Bessho H, Kusuhara S, Tsukahara Y, Negi A.
  • Journal Title: J Ophthalmol. Volume: 2011 Pages: 742020-742020
  • DOI: 10.1155/2011/742020
  • Peer Reviewed
• [Journal Article] Impact of Intravitreal Injection of Tissue Plasminogen Activator on Full-Field Electroretinogram in Patients with Macular Oedema Secondary to Retinal Vein Occlusion. (2011)
  • Author(s): Tagami M, Kusuhara S, Imai H, Honda S, Tsukahara Y, Negi A.
  • Journal Title: Ophthalmologica Volume: 226 Issue: 2 Pages: 81-86
  • DOI: 10.1159/000326242
  • Peer Reviewed
• [Journal Article] Natural course and funduscopic findings of polypoidal choroidal vasculopathy in a Japanese population over one year of follow-up. (2011)
  • Author(s): Bessho H, Honda S, Imai H, Negi A.
  • Journal Title: Retina Volume: 31 Issue: 8 Pages: 1598-1602
  • DOI: 10.1097/iae.0b013e31820d3f28
  • Peer Reviewed
• [Journal Article] The association of ARMS2 polymorphisms with phenotype in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. (2011)
  • Author(s): Bessho H, Honda S, Kondo N, Negi A.
  • Journal Title: Mol Vis. Volume: 17 Pages: 977-982
  • Peer Reviewed
• [Journal Article] Comparison between anti-vascular endothelial growth factor therapy and photodynamic therapy for myopic choroidal neovascularization. (2011)
  • Author(s): Matsuo M, Honda S, Matsumiya W, Kusuhara S, Tsukahara Y, Negi A.
  • Journal Title: Eur J Ophthalmol. Volume: 22 Issue: 2 Pages: 210-215
  • DOI: 10.5301/ejo.2011.7750
  • Peer Reviewed
• [Journal Article] Positive association of complement factor H gene variants with the effect of photodynamic therapy in polypoidal choroidal vasculopathy. (2011)
  • Author(s): Bessho H, Honda S, Kondo N, Nishimura K, Negi A.
  • Journal Title: J Clinic Experiment Ophthalmol. Volume: 2 Pages: 122-122
  • DOI: 10.4172/2155-9570.1000122
  • Peer Reviewed
• [Journal Article] Comparison of the outcomes of photodynamic therapy between two angiographic subtypes of polypoidal choroidal vasculopathy
  • Author(s): Honda S, Miki A, Yanagisawa S, Matsumiya W, Nagai T, Tsukahara Y
  • Journal Title: Ophthalmologica Volume: (in press)
  • Peer Reviewed
• [Presentation] The Short Term Outcomes of a Single Intravitreal Injection of Aflibercept Combined With Photodynamic Therapy for Polypoidal Choroidal Vasculopathy (2013)
  • Author(s): Shigeru Honda, Wataru Matsumiya, Suiho Yanagisawa, Akiko Miki, Takayuki Nagai, Yasutomo Tsukahara
  • Organizer: APRVS
  • Place of Presentation: Nagoya
• [Presentation] The early response to aflibercept in the recurrent neovascular age-related macular degeneration after ranibizumab treatment (2013)
  • Author(s): Wataru Matsumiya, Shigeru Honda, Suiho Yanagisawa, Akiko Miki, Takayuki Nagai, Yasutomo Tsukahara
  • Organizer: APRVS
  • Place of Presentation: Nagoya
• [Presentation] The natural course and response to treatments in the cases with peripapillary polypoidal choroidal vasclopathy (2013)
  • Author(s): Akiko Miki, Shigeru Honda, Suiho Yanagisawa, Wataru Matsumiya, Takayuki Nagai, Yasutomo Tsukahara
  • Organizer: APRVS
  • Place of Presentation: Nagoya
• [Presentation] The association of elastin gene variants with two angiographic subtypes of polypoidal choroidal vasculopathy (2013)
  • Author(s): Shigeru Honda, Suiho Yanagisawa, Akiko Miki, Wataru Matsumiya, Akira Negi
  • Organizer: ARVO
  • Place of Presentation: Seattle
• [Presentation] The Short Term Outcomes of a Single Intravitreal Injection of Aflibercept Combined With Photodynamic Therapy for Polypoidal Choroidal Vasculopathy (2013)
  • Author(s): Shigeru Honda, Wataru Matsumiya, Suiho Yanagisawa, Akiko Miki, Takayuki Nagai, Yasutomo Tsukahara
  • Organizer: The 8th APRVS
  • Place of Presentation: Nagoya
• [Presentation] The early response to aflibercept in the recurrent neovascular age-related macular degeneration after ranibizumab treatment (2013)
  • Author(s): Wataru Matsumiya, Shigeru Honda, Suiho Yanagisawa, Akiko Miki, Takayuki Nagai, Yasutomo Tsukahara
  • Organizer: The 8th APRVS
  • Place of Presentation: Nagoya
• [Presentation] The natural course and response to treatments in the cases with peripapillary polypoidal choroidal vasclopathy (2013)
  • Author(s): Akiko Miki, Shigeru Honda, Suiho Yanagisawa, Wataru Matsumiya, Takayuki Nagai, Yasutomo Tsukahara
  • Organizer: The 8th APRVS
  • Place of Presentation: Nagoya
• [Presentation] The association of elastin gene variants with two angiographic subtypes of polypoidal choroidal vasculopathy. (2013)
  • Author(s): Shigeru Honda, Suiho Yanagisawa, Akiko Miki, Wataru Matsumiya, Akira Negi
  • Organizer: ARVO 2013
  • Place of Presentation: Seattle
• [Presentation] ポリープ状脈絡膜血管症のインドシアニングリーン蛍光造影所見とエラスチン遺伝子多型 (2013)
  • Author(s): 本田 茂, 三木 明子, 柳沢 翠芳, 近藤 直士, 松宮 亘, 根木 昭.
  • Organizer: 第117回 日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] 日本人の成人発症卵黄状黄斑ジストロフィーにおけるRDS遺伝子多型の検討 (2013)
  • Author(s): 柳沢 翠芳(神戸大学), 三木 明子, 松宮 亘, 近藤 直士, 本田 茂, 塚原 康友, 根木 昭.
  • Organizer: 第117回 日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] ポリープ状脈絡膜血管症に対する光線力学療法の治療効果に関連する因子の検討 (2013)
  • Author(s): 本田茂、柳沢翠芳、三木明子、松宮亘、長井隆行、塚原康友.
  • Organizer: 第67回 日本臨床眼科学会
  • Place of Presentation: 横浜
• [Presentation] AMDに対するranibizumab硝子体注射の導入期治療の成績に関与する遺伝的因子の検討 (2013)
  • Author(s): 松宮亘、本田茂、柳沢翠芳、三木明子、長井隆行、塚原康友.
  • Organizer: 第67回 日本臨床眼科学会
  • Place of Presentation: 横浜
• [Presentation] 黄斑浮腫を伴う網膜中心静脈閉塞症に対するBevacizumab治療の6カ月成績と予後予測因子 (2013)
  • Author(s): 広瀬美樹、松宮亘、柳沢翠芳、三木明子、長井隆行、本田茂、塚原康友.
  • Organizer: 第67回 日本臨床眼科学会
  • Place of Presentation: 横浜
• [Presentation] 網膜中心静脈閉塞症合併黄斑浮腫にBevacizumab硝子体内注射後無還流領域を来たした症例 (2013)
  • Author(s): 柳沢翠芳、本田茂、三木明子、松宮亘、長井隆行、塚原康友.
  • Organizer: 第67回 日本臨床眼科学会
  • Place of Presentation: 横浜
• [Presentation] 眼科における個別化医療の可能性 ～加齢黄斑変性医療の現場から～ (2013)
  • Author(s): 本田茂
  • Organizer: 第22回島根眼科研究会
  • Place of Presentation: 出雲
  • Invited
• [Presentation] ポリープ状脈絡膜血管症に対する光線力学療法とラニビズマブの比較 LAPTOP study (2012)
  • Author(s): 小嶌洋史, 万代道子, 大石明生, 栗本康夫, 本田茂, 根木昭, 松岡俊行, 王英泰、喜多美穂里, 長井知子, 藤原雅史, 上西衛
  • Organizer: 第５０回日本網膜硝子体学会総会
  • Place of Presentation: 甲府
• [Presentation] ポリープ状脈絡膜血管症の血管造影に基づくサブタイプと光線力学療法の治療効果の検討 (2012)
  • Author(s): 本田茂、三木明子、柳沢翠芳、松宮亘、長井隆行、近藤直士、塚原康友、根木昭
  • Organizer: 第５０回日本網膜硝子体学会総会
  • Place of Presentation: 甲府
• [Presentation] 中心性漿液性脈絡網膜症に対する低照射エネルギーPDTの短期成績 (2012)
  • Author(s): 三木明子, 本田 茂, 松宮亘、柳沢翠芳、長井 隆行, 近藤直士、塚原康友, 根木昭
  • Organizer: 第５０回日本網膜硝子体学会総会
  • Place of Presentation: 甲府
• [Presentation] 加齢黄斑変性に対するranibizumab硝子体注射の24カ月成績 (2012)
  • Author(s): 松宮亘、本田 茂、柳沢翠芳、三木明子、長井隆行, 近藤直士、塚原康友, 根木昭
  • Organizer: 第５０回日本網膜硝子体学会総会
  • Place of Presentation: 甲府
• [Presentation] 中心性漿液性脈絡網膜症に対する光線力学療法のレーザー照射径と治療効果に関する検討 (2012)
  • Author(s): 本田茂、三木明子、柳沢翠芳、松宮亘、長井隆行、近藤直士、楠原仙太郎、塚原康友、根木昭
  • Organizer: 第66回日本臨床眼科学会
  • Place of Presentation: 京都
• [Presentation] ポリープ状脈絡膜血管症における脳動脈瘤および腹部大動脈瘤関連遺伝子多型 (2012)
  • Author(s): 柳沢翠芳、近藤直士、三木明子、本田茂、根木昭
  • Organizer: 第66回日本臨床眼科学会
  • Place of Presentation: 京都
• [Presentation] 両眼にポリープ状脈絡膜血管症を生じた一卵性双生児の症例 (2012)
  • Author(s): 三木明子、近藤直士、柳沢翠芳、松宮亘、長井隆行、楠原仙太郎、塚原康友、本田茂、根木昭
  • Organizer: 第66回日本臨床眼科学会
  • Place of Presentation: 京都
• [Presentation] 加齢黄斑変性に対するルセンティス治療に関する多施設前向きゲノムワイド関連解析 (2012)
  • Author(s): 山城健児、森圭介、本田茂、赤堀正和、米谷新、根木昭、岩田岳、吉村長久、エンジェルスタディグループ
  • Organizer: 第66回日本臨床眼科学会
  • Place of Presentation: 京都
• [Presentation] 近視性脈絡膜血管新生に対するビスフォスフォネート薬内服の中期効果 (2012)
  • Author(s): 三木明子、 本田茂, 長井隆行, 楠原仙太郎, 塚原康友, 根木昭
  • Organizer: 第116回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] ranibizumab硝子体内投与後のAMD再発例における臨床的及び遺伝的関連因子の検討 (2012)
  • Author(s): 松宮亘, 本田茂, 柳沢翠芳, 三木明子, 長井隆行, 近藤直士, 楠原仙太郎, 塚原康友, 根木昭
  • Organizer: 第116回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] 中心性漿液性脈絡網膜症におけるARMS2およびCFH多型の検討 (2012)
  • Author(s): 本田茂, 別所弘明, 柳沢翠芳, 近藤直士, 楠原仙太郎, 塚原康友, 根木昭
  • Organizer: 第116回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] 加齢黄斑変性の病態および光線力学療法の作用機序におけるCD36の関連 (2012)
  • Author(s): 本田茂、柳沢翠芳、三木明子、松宮亘、近藤直士、根木昭
  • Organizer: 第23回日本眼科酸化ストレス研究会
  • Place of Presentation: 神戸
• [Presentation] 加齢黄斑変性医療の現在、過去、未来～迷い道くねくね～ (2012)
  • Author(s): 本田茂
  • Organizer: 第2回仙台網膜道場
  • Place of Presentation: 仙台
  • Invited
• [Presentation] 標準化医療から個別化医療への転換 ～加齢黄斑変性治療の現場から～ (2012)
  • Author(s): 本田茂
  • Organizer: 第150回宮崎県眼科医会講習会
  • Place of Presentation: 宮崎
  • Invited
• [Presentation] Genetic risk factors for Photodynamic therapy in Polypoidal Choroidal Vasculopathy (2012)
  • Author(s): Shigeru Honda
  • Organizer: AMD Expert Meeting 2012
  • Place of Presentation: 大阪
  • Invited
• [Presentation] Early Responses to Intravitreal Ranibizumab in Typical Neovascular Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy (2011)
  • Author(s): Wataru Matsumiya, Shigeru Honda, Hiroaki Bessho, Sentaro Kusuhara, Yasutomo Tsukahara, Akira Negi
  • Organizer: ARVO
  • Place of Presentation: Fort Lauderdale
• [Presentation] 日本人加齢黄斑変性に対する遺伝情報を利用した光線力学療法の検討 (2011)
  • Author(s): 本田茂、別所弘明、松宮亘、近藤直士、楠原仙太郎、塚原康友、根木昭
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] Early Responses to Intravitreal Ranibizumab in Typical Neovascular Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy. (2011)
  • Author(s): Wataru Matsumiya, Shigeru Honda, Hiroaki Bessho, Sentaro Kusuhara, Yasutomo Tsukahara, Akira Negi.
  • Organizer: The Association for Research in Vision and Ophthalmology
  • Place of Presentation: Fort Lauderdale Convention centor
• [Presentation] 日本人加齢黄斑変性に対する遺伝情報を利用した光線力学療法の検討 (2011)
  • Author(s): 本田茂、別所弘明、松宮亘、近藤直士、楠原仙太郎、塚原康友、根木昭
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 網膜内血管腫状増殖に対する光線力学単独療法とテノン嚢下トリアムシノロン併用の比較 (2011)
  • Author(s): 中野沙弥 本田茂 喜多美穂里 根木昭
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 近視性脈絡膜血管新生に対する光線力学療法と抗VEGF療法の治療成績 (2011)
  • Author(s): 松尾美佐、本田茂、松宮亘、別所弘明、楠原仙太郎、塚原康友、根木昭
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] インストラクションコース４ 加齢黄斑変性医療に必要なゲノム学を理解しよう ～遺伝情報から加齢黄斑変性の病態を考察する～ (2011)
  • Author(s): 本田茂
  • Organizer: 第６５回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 狭義加齢黄斑変性とポリープ状脈絡膜血管症におけるCD36遺伝子多型 (2011)
  • Author(s): 本田茂、別所弘明、柳沢翠芳、近藤直士、松宮亘、三木明子、長井隆行、楠原仙太郎、塚原康友、根木昭
  • Organizer: 第６５回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 狭義加齢黄斑変性とポリープ状脈絡膜血管症に対するranibizumab硝子体注射の治療成績 (2011)
  • Author(s): 松宮亘、本田茂、柳沢翠芳、三木明子、長井隆行、近藤直士、長井隆行、楠原仙太郎、塚原康友、根木昭
  • Organizer: 第６５回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 広義滲出型加齢黄斑変性に対する光線力学療法の兵庫県下多施設研究~5年成績報告~ (2011)
  • Author(s): 三木明子、本田茂、根木昭、小嶌洋史、栗本康夫、西崎雅也、上西衛、喜多美穂里、長井知子
  • Organizer: 第６５回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] ポリープ状脈絡膜血管症に対する光線力学療法の治療効果とCD36遺伝子多型との関連の検討 (2011)
  • Author(s): 本田茂、別所宏朗、柳沢翠芳、根木昭
  • Organizer: 第５０回日本網膜硝子体学会総会TEAM2011
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 日本人PCVにおけるインドシアニングリーン蛍光造影所見とARMS2遺伝子およびCFH遺伝子との関連の検討 (2011)
  • Author(s): 三木明子、本田茂、別所宏朗、近藤直士、田中公二、湯澤美都子、根木昭
  • Organizer: 第５０回日本網膜硝子体学会総会TEAM2011
  • Place of Presentation: 東京国際フォーラム
• [Presentation] ポリープ状脈絡膜血管症に対するＰＤＴとラニビズマブの比較～LAPTOP study～ (2011)
  • Author(s): 小嶌洋史、万代道子、大石明生、栗本康夫、本田茂、根木昭、松岡俊行、喜多美穂里、長井知子、藤原雅史、上西衛
  • Organizer: 第５０回日本網膜硝子体学会総会TEAM2011
  • Place of Presentation: 東京国際フォーラム
• [Book] AGEsと加齢黄斑変性:AGEsと老化―糖化制御からみたウェルエイジング (2013)
  • Author(s): 本田茂
  • Publisher: メディカルレビュー社
• [Book] 網膜の機能:眼科学(第2版)(編:丸尾敏夫ら) (2011)
  • Author(s): 本田茂
  • Publisher: 文光堂