Disclose the role and develop a new therapy regulating adrenergic receptor alpha 1 for retinopathy of prematurity
| Project/Area Number |
23592569
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Shigeru 神戸大学, 医学部附属病院, 講師 (60283892)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 未熟児網膜症 / アドレナリン受容体 / ノックアウトマウス / アドレナリンα1受容体 / 高酸素負荷モデル |
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| Research Abstract |
To disclose the role of adrenergic receptor (ADR) alpha 1 in the development of retinopathy of prematurity (ROP) we tried to develop ADR alpha 1A, 1B and 1D knock out (KO) mice and to compare the feature of experimental ROP model (oxygen induced retinopathy) between KO mice and wild mice. Although it was very difficult to make double or triple KO mice, we have succeeded to obtain single KO mouse of each subtype. We will continue the research after this time period.
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] VEGF 936C>T is predictive of threshold retinopathy of prematurity in Japanese infants with a 30-week gestational age or less2011
Author(s)
Yagi M, Yamamori M, Morioka I, Yokoyama N, Honda S, Negi A, Nakamura T, Okamura N, Okumura K, Sakaeda T, Matsuo M
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Journal Title
Research and Reports in Neonatology
Volume: 1
Pages: 5-11
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Peer Reviewed
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[Journal Article] A surviving case of papillorenal syndrome with the phenotype of Potter sequence.2011
Author(s)
Fujioka K, Morioka I, Nozu K, Nishimoto M, Amano M, Tagami M, Honda S, Yokoyama N, Yamada H, Iijima K, Matsuo M.
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Journal Title
Pediatr Int.
Volume: 3
Issue: 3
Pages: 406-408
DOI
NAID
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Peer Reviewed
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[Presentation] ポリープ状脈絡膜血管症に対する光線力学療法とラニビズマブの比較 LAPTOP study2012
Author(s)
小嶌洋史, 万代道子, 大石明生, 栗本康夫, 本田茂, 根木昭, 松岡俊行, 王英泰、喜多美穂里, 長井知子, 藤原雅史, 上西衛
Organizer
第５０回日本網膜硝子体学会総会
Place of Presentation
甲府
Related Report
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