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Molecular mechanism of short pulse laser retinal photocoagulation in ischemic retina

Research Project

Project/Area Number 23592579
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionNagoya City University

Principal Investigator

YOSHIDA MUNENORI  名古屋市立大学, 医学(系)研究科(研究院), 准教授 (60273447)

Co-Investigator(Kenkyū-buntansha) OGURA Yuichiro  名古屋市立大学, 大学院医学研究科, 教授 (70191963)
NOZAKI Miho  名古屋市立大学, 大学院医学研究科, 講師 (00295601)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords網膜光凝固 / 網膜新生血管 / 網膜虚血 / ショートパルスレーザー / VEGF / 未熟児網膜症 / 糖尿病網膜症 / 光凝固 / ショートパルス
Research Abstract

Short pulse duration laser has been reported that induced less damage into inner retina and less pain for patients. However, some researchers reported that retinal photocoagulation with short pulse laser might be less effective than that with conventional laser photocoagulation. The purpose of this study was to determine the efficacy of short pulse laser photocoagulation in ischemic murine retina. Short pulse laser induced less damage to the murine inner retina, and the size of lateral scar formation was 70% of that with conventional laser. And the reduction of VEGF was less with short pulse laser compared with conventional laser. Our findings indicated that we have to perform laser photocoagulation with tighter spacing and more number of treatment spots when we use short pulse laser.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results)

  • [Journal Article] 糖尿病網膜症に対する汎網膜光凝固術―従来凝固法とパターン凝固の比較2014

    • Author(s)
      山川めぐみ、野崎実穂、佐藤里奈、森田裕、吉田宗徳、小椋祐一郎
    • Journal Title

      日眼会誌

      Volume: 118巻 Pages: 362-367

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of retinopathy of prematurity treated by pattern scan laser photocoagulation2014

    • Author(s)
      Satoshi Ota, Miho Nozaki, Shuichiro Hirahara, Tomoaki Hattori, Munenori Yoshida, Yuichiro Ogura
    • Journal Title

      Clinical Ophthalmology

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 糖尿病網膜症に対する汎網膜光凝固術―従来凝固法とパターン凝固の比較2014

    • Author(s)
      山川めぐみ、野崎実穂、佐藤里奈、森田 裕、吉田宗徳、小椋祐一郎
    • Journal Title

      日本眼科学会雑誌

      Volume: 118 Pages: 362-367

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of retinopathy of prematurity treated by pattern scan laser photocoagulation.2014

    • Author(s)
      Ota S, Nozaki M, Hirahara S, Hattori T, Yoshida Y, Ogura Y
    • Journal Title

      Clinical Ophthalmology

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 糖尿病網膜症に対する汎網膜光凝固術―従来凝固法とパターン凝固の比較—2013

    • Author(s)
      山川めぐみ、佐藤里奈、野崎実穂、森田裕、吉田宗徳、小椋祐一郎
    • Organizer
      第36回日本眼科手術学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2013-01-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖尿病網膜症に対する汎網膜光凝固術ー通常凝固とパターン凝固の比較2013

    • Author(s)
      山川めぐみ、野崎実穂、森田裕、吉田宗徳、小椋祐一郎
    • Organizer
      第36回日本眼科手術学会総会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Research-status Report
  • [Presentation] Comparison of Outcomes of conventional laser vs. Pascal Laser for Diabetic Retinopathy2012

    • Author(s)
      Miho NOZAKI, Munenori YOSHIDA, Yuichiro OGURA
    • Organizer
      Asia Pacific Academy of Ophthalmology, 2012
    • Place of Presentation
      ベクスコ(Busan, Korea)
    • Related Report
      2012 Research-status Report
  • [Presentation] PASCAL streamline yellowの使用経験2012

    • Author(s)
      西川薫里、野崎実穂、水谷武史、吉田宗徳、小椋祐一郎
    • Organizer
      第35回日本眼科手術学会総会
    • Place of Presentation
      名古屋国際会議場( 愛知県)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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