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Influence of high fat diet in the retina

Research Project

Project/Area Number 23592588
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionKeio University

Principal Investigator

SHINODA Hajime  慶應義塾大学, 医学部, 講師 (30306766)

Co-Investigator(Kenkyū-buntansha) OZAWA Yoko  慶應義塾大学, 医学部, 講師 (90265885)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords網膜 / 生活習慣病 / 肥満 / 糖尿病
Research Abstract

Recent increase in the prevalence of metabolic syndrome, which includes vision threatening diseases such as diabetic retinopathy and age-related macular degeneration, is a social issue. Metabolic syndrome includes obesity and high fat diet, which are also known risk factors of diabetic retinopathy and age-related macular degeneration. However, the underlying mechanisms of the relationship between obesity and high fat diet, and retinal diseases were still obscure. In this study, we analyzed the influence of high fat diet in the retina of mice; we evaluated systemic and retinal inflammatory cytokines.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (43 results)

All 2014 2013 2012 2011 Other

All Journal Article (22 results) (of which Peer Reviewed: 22 results,  Open Access: 1 results) Presentation (19 results) Remarks (2 results)

  • [Journal Article] Ozawa Predictive factors for non-responders to intravitreal ranibizumab treatment in age-related macular degeneration2014

    • Author(s)
      Suzuki M, Nagai N, Izumi-Nagai K, Shinoda H, Koto T, Uchida A, Mochimaru H, Yuki K, Sasaki M, Tsubota K
    • Journal Title

      Br J Ophthalmol

      Volume: 98 Issue: 9 Pages: 7-7

    • DOI

      10.1136/bjophthalmol-2013-304670

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Serum Lipids with Macular Thickness and Volume in Type 2 Diabetes without Diabetic Macular Edema.2014

    • Author(s)
      Sasaki M, Kawashima M, Kawasaki R, Uchida A, Koto T, Shinoda H, Tsubota K, Jie Jin Wang, Ozawa Y
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 55 Issue: 3 Pages: 1749-1753

    • DOI

      10.1167/iovs.13-13035

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vitrectomy for myopic foveoschisis with internal limiting membrane peeling and no gas tamponade.2013

    • Author(s)
      Uchida A, Shinoda H, Koto T, Mochimaru H, Nagai N, Tsubota K, Ozawa Y
    • Journal Title

      Retina.

      Volume: 34 Issue: 3 Pages: 455-460

    • DOI

      10.1097/iae.0b013e3182a0e477

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Early Visual Impairment in Patients with Epiretinal Membrane.2013

    • Author(s)
      Nishi Y, Shinoda H, Uchida A, Koto T, Mochimaru H, Nagai N, Tsubota K, Ozawa Y.
    • Journal Title

      Acta Ophthalmologica

      Volume: Epub ahead of print Issue: 5 Pages: 1-5

    • DOI

      10.1111/aos.12060

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum vascular adhesion protein-1 correlates with vascular endothelial growth factor in patients with type II diabetes.2013

    • Author(s)
      Yoshikawa N, Noda K, Shinoda H, Uchida A, Ozawa Y, Tsubota K, Mashima Y, Ishida S.
    • Journal Title

      J Diabetes Complications.

      Volume: 27 Issue: 2 Pages: 162-6

    • DOI

      10.1016/j.jdiacomp.2012.09.001

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Renin-angiotensin system involvement in the oxidative stress-induced neurodegeneration of cultured retinal ganglion cells.2013

    • Author(s)
      Ozawa Y, Yuki K, Yamagishi R, Tsubota K, Aihara M.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 57 Issue: 1 Pages: 126-32

    • DOI

      10.1007/s10384-012-0204-x

    • NAID

      10031168368

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Usage of micronutrient supplement for preventing advanced Age-related Macular Degeneration in Japan2012

    • Author(s)
      Sasaki M, Shinoda H, Koto T, Uchida A, Tsubota K, Ozawa Y
    • Journal Title

      Archives of Ophthalmology

      Volume: 130(2) Issue: 2 Pages: 254-5

    • DOI

      10.1001/archopthalmol.2011.1368

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Presence and physiological function of Renin-Angiotensin System in mouse lacrimal gland.2012

    • Author(s)
      Yaguchi S, Ogawa Y, Shimmura S, Hatou S, Nakamura S, Inaba T, Imada T, Ozawa Y, Kawakami Y, Ishida S, Tsubota K.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 53 Issue: 9 Pages: 5416-25

    • DOI

      10.1167/iovs.12-9891

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Photo-damage mechanisms and anti-apoptotic effect of lutein in the mouse retina.2012

    • Author(s)
      Miyake S, Sasaki M, Takahashi N, Tsubota K, Ozawa Y.
    • Journal Title

      Inflammation and Regeneration.

      Volume: 32 Pages: 208-12

    • NAID

      130004482301

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Soluble Vascular Adhesion Protein-1 Accumulates in Proliferative Diabetic Retinopathy.2012

    • Author(s)
      Murata M, Noda K, Fukuhara J, Kanda A, Kase S, Saito W, Ozawa Y, Mochizuki S, Kimura S, Mashima Y, Okada Y, Ishida S.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 53 Issue: 7 Pages: 4055-62

    • DOI

      10.1167/iovs.12-9857

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Blockade of vascular adhesion protein-1 attenuates choroidal neovascularization.2012

    • Author(s)
      Yoshikawa N, Noda K, Ozawa Y, Tsubota K, Mashima Y, Ishida S.
    • Journal Title

      Mol Vis.

      Volume: 18 Pages: 593-600

    • NAID

      120005372295

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract : cellular and molecular mechanism2012

    • Author(s)
      Miyake S, Takahashi N, Sasaki M, Kobayashi S, Tsubota K, Ozawa Y
    • Journal Title

      Lab Invest

      Volume: 92(1) Issue: 1 Pages: 102-9

    • DOI

      10.1038/labinvest.2011.132

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Biological role of lutein in the light-induced retinal degeneration2012

    • Author(s)
      Sasaki M, Yuki K, Kurihara T, Miyake S, Noda K, Kobayashi S, Ishida S, Tsubota K, Ozawa Y.
    • Journal Title

      J Nutr Biochem

      Volume: 23 Issue: 5 Pages: 423-429

    • DOI

      10.1016/j.jnutbio.2011.01.006

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute visual field defect following vitrectomy determined to originate from optic nerve by electrophysiological tests.2012

    • Author(s)
      Uchida A, Shinoda K, Matsumoto C.S, Kawai M, Kawai S, Ohde H, Ozawa Y, Ishida S, Inoue M, Mizota A, Tsubota K.
    • Journal Title

      Case Rep Ophthalmol.

      Volume: 3 Issue: 3 Pages: 396-405

    • DOI

      10.1159/000345507

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective Effects of Lutein in the Retina2012

    • Author(s)
      Ozawa Y, Sasaki M, Takahashi N, Kamoshita M, Miyake S, Tsubota K
    • Journal Title

      Current Pharmaceutical Design

      Volume: 18(2) Issue: 1 Pages: 51-6

    • DOI

      10.2174/138161212798919101

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical findings in a choroideremia patient who underwent vitrectomy for retinal detachment associated with macular hole2011

    • Author(s)
      Shinoda H, Koto T, Fujiki K, Murakami A, Tsubota K, Ozawa Y
    • Journal Title

      Jpn J Ophthalmol

      Volume: 55(2) Issue: 2 Pages: 169-71

    • DOI

      10.1007/s10384-010-0911-0

    • NAID

      10029021013

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner2011

    • Author(s)
      Nakamura-Ishizu A, Kurihara T, Okuno Y, Ozawa Y, Kishi K, Goda N, Tsubota K, Okano H, Suda T, Kubota Y
    • Journal Title

      Dev Biol

      Volume: 363 Issue: 1 Pages: 106-114

    • DOI

      10.1016/j.ydbio.2011.12.027

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective response after photodynamic therapy : Role of vascular endothelial growth factor2011

    • Author(s)
      Suzuki M, Ozawa Y, Kubota S, Hirasawa M, Miyake S, Noda K, Tsubota K, Kadonosono K, Ishida S
    • Journal Title

      J Neuroinflammation

      Volume: 8 Issue: 1 Pages: 176-176

    • DOI

      10.1186/1742-2094-8-176

    • NAID

      120005372300

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neural degeneration in the retina of the streptozotocin(STZ)-induced type 1 diabetes model2011

    • Author(s)
      Ozawa Y, Kurihara T, Sasaki M, Ban N, Yuki K, Kubota S, Tsubota K
    • Journal Title

      Experimental Diabetes Research 2011

      Volume: 2011 Pages: 108328-108328

    • DOI

      10.1155/2011/108328

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Roles of AMP-activated protein kinase in diabetes-induced retinal inflammation2011

    • Author(s)
      Kubota S, Ozawa Y, Kurihara T, Sasaki M, Yuki K, Miyake S, Noda K, Ishida S, Tsubota K.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Issue: 12 Pages: 9142-9148

    • DOI

      10.1167/iovs.11-8041

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Retinal ganglion cell loss in superoxide dismutase 1-deficiency2011

    • Author(s)
      Yuki K, Ozawa Y, Yoshida T, Kurihara T, Hirasawa M, Ozeki N, Shiba D, Noda K, Ishida S, Tsubota K.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Issue: 7 Pages: 4143-4150

    • DOI

      10.1167/iovs.10-6294

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovascularization.2011

    • Author(s)
      Hirasawa M, Noda K, Noda S, Suzuki M, Ozawa Y, Shinoda K, Inoue M, Ogawa Y, Tsubota K, Ishida S.
    • Journal Title

      Mol Vis.

      Volume: 17 Pages: 1222-30

    • NAID

      120005372298

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 狭義加齢黄斑変性に対するpro re nateによるラニビズマブ硝子体注射2013

    • Author(s)
      鈴木美砂, 永井紀博, 永井香奈子, 篠田肇, 内田敦郎, 厚東隆志, 持丸博史, 富田洋平, 佐々木真理子, 坪田一男, 小沢洋子
    • Organizer
      第67回日本臨床眼科学会
    • Place of Presentation
      神奈川 横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 抗VEGF療法に反応不良の滲出型加齢黄斑変性に対するアフリベルセプトの作用2013

    • Author(s)
      永井紀博, 永井香奈子, 鈴木美砂, 持丸博史, 富田洋平, 内田敦郎, 佐々木真理子, 篠田肇, 坪田一男, 小沢洋子
    • Organizer
      第67回日本臨床眼科学会
    • Place of Presentation
      神奈川 横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Associations of Serum Lipids with Macular Morphology in Patients without Diabetic Macular Edema2013

    • Author(s)
      Sasaki M, Kawashima M, Kawasaki R, Kawai M, Uchida A, Koto T, Mochimaru H, Shinoda H, Jie Jin Wang, Tsubota K, Ozawa Y
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
    • Place of Presentation
      Washington State Convention & Trade Center Seattle, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Baseline characteristics and response to intravitreal ranibizumab therapy for age-related macular degeneration2013

    • Author(s)
      Suzuki M, Nagai N, Izumi-Nagai K, Shinoda H, Koto T, Uchida A, Mochimaru H, Yuki K, Tsubota K, Ozawa Y
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
    • Place of Presentation
      Washington State Convention & Trade Center Seattle, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 狭義加齢黄斑変性に対するpro re nateによるラニビズマブ硝子体注射.2013

    • Author(s)
      3. 鈴木美砂, 永井紀博, 永井香奈子, 篠田肇, 内田敦郎, 厚東隆志, 持丸博史, 富田洋平, 佐々木真理子, 坪田一男, 小沢洋子.
    • Organizer
      第67回日本臨床眼科学会
    • Place of Presentation
      パシフィコ横浜 神奈川県 横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 加齢黄斑変性に対するラニビズマブ単独治療における導入期の有効性についての検討2012

    • Author(s)
      鈴木美砂、永井紀博、永井香奈子、篠田肇、内田敦郎、厚東隆志、持丸博史、小沢洋子、坪田一男
    • Organizer
      第66回日本臨床眼科学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 健常者における黄斑色素密度と血清カロテノイド濃度の相関2012

    • Author(s)
      永井紀博, 小林文貴, 永井香奈子, 鈴木美砂, 持丸博史, 内田敦郎, 厚東隆志, 篠田肇, 三宅誠司, 小林沙織, 坪田一男, 小沢洋子
    • Organizer
      第66回日本臨床眼科学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 網膜静脈分枝閉塞症に伴う黄斑浮腫に対するベバシズマブテノン嚢下注射の効果の検討2012

    • Author(s)
      厚東隆志, 林李恵, 篠田肇, 永井紀博, 内田敦郎, 持丸博史, 坪田一男, 小沢洋子
    • Organizer
      第66回日本臨床眼科学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 新規過活動膀胱治療薬ミラベグロン投与後早期に発症した網膜静脈分枝閉塞症の一例2012

    • Author(s)
      持丸博史, 前田高宏, 厚東隆志, 内田敦郎, 永井紀博, 篠田肇, 坪田一男, 小沢洋子
    • Organizer
      第66回日本臨床眼科学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Associations Between Early Signs Of Age-related Macular Degeneration (AMD) And Risk Of AMD In The Fellow Eye In Patients With Unilateral AMD2012

    • Author(s)
      Sasaki M, Kawasaki R, Uchida A, Koto T, Mochimaru H, Shinoda H, Tien Y. Wong, Tsubota K, Ozawa Y
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
    • Place of Presentation
      Fort Lauderdale, U.S.A.
    • Related Report
      2013 Final Research Report
  • [Presentation] 片眼加齢黄斑変性患者における前駆病変と僚眼発症の関連2012

    • Author(s)
      佐々木真理子, 川崎良, 内田敦郎, 厚東隆志, 持丸博史, 篠田肇, 鈴木美砂, 永井香奈子, 永井紀博, 坪田一男, 小沢洋子
    • Organizer
      第116回日本眼科学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] ボリコナゾール内服による視覚障害から視放線の病変が見つかった再生不良性貧血の一例2012

    • Author(s)
      堀野武, 内田敦郎, 持丸博史, 厚東隆志, 永井紀博, 篠田肇, 篠田啓, 大出尚郎, 小沢洋子, 坪田一男
    • Organizer
      第116回日本眼科学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 実用視力測定法を用いた特発性網膜上膜術後の視機能変化の評価2012

    • Author(s)
      常吉由佳里, 篠田肇, 西恭代, 厚東隆志, 内田敦郎, 永井紀博, 坪田一男, 小沢洋子
    • Organizer
      第35回日本眼科手術学会
    • Place of Presentation
      愛知 名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 内境界膜剥離併用硝子体手術で中心窩網膜分離が改善したX染色体性若年性網膜分離の1例2011

    • Author(s)
      川島弘彦, 篠田肇, 持丸博史, 内田敦郎, 厚東隆志, 永井紀博, 小沢洋子, 坪田一男
    • Organizer
      第50回日本網膜硝子体学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 加齢黄斑変性に対するラニビズマブ治療における無効症例の検討2011

    • Author(s)
      鈴木美砂, 佐々木真理子, 厚東隆志, 持丸博史, 内田敦郎, 永井香奈子, 永井紀博, 篠田肇, 坪田一男, 小沢洋子
    • Organizer
      第65回日本臨床眼科学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 視力1.0以上の網膜上膜に対する実用視力測定の有効性2011

    • Author(s)
      西恭代, 篠田肇, 結城賢弥, 内田敦郎, 厚東隆志, 小沢洋子, 坪田一男
    • Organizer
      第34回日本眼科手術学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Inflammatory Signals in the Pathogenesis of Diabetic Retinopathy2011

    • Author(s)
      Yoko Ozawa
    • Organizer
      IOIS
    • Place of Presentation
      Hotel Taj Exotica, Goa, India
    • Related Report
      2011 Research-status Report
  • [Presentation] Associations of Serum Lipids with Macular Morphology in Patients without Diabetic Macular Edema.

    • Author(s)
      Sasaki M, Kawashima M, Kawasaki R, Kawai M, Uchida A, Koto T, Mochimaru H, Shinoda H, Jie Jin Wang, Tsubota K, Ozawa Y.
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting:
    • Place of Presentation
      Washington State Convention & Trade Center Seattle, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Baseline characteristics and response to intravitreal ranibizumab therapy for age-related macular degeneration.

    • Author(s)
      Suzuki M, Nagai N, Izumi-Nagai K, Shinoda H, Koto T, Uchida A, Mochimaru H, Yuki K, Tsubota K, Ozawa Y.
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
    • Place of Presentation
      Washington State Convention & Trade Center Seattle, USA
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.keio-eye.net/

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.keio-eye.net/research/rcb.html

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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