Focus on mechanism of chronic ocular graft-vessus-host disease caused by donor-derived mesenchymal stem cells toward development of new treatment.

• Project/Area Number: 23592590
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Keio University
• Principal Investigator: OGAWA Yoko 慶應義塾大学, 医学部, 特任准教授 (30160774)
• Co-Investigator(Renkei-kenkyūsha): TUBOTA Kazuo 慶應義塾大学, 医学部, 教授 (40163878) ; SHIMMURA Shigeto 慶應義塾大学, 医学部, 准教授 (00235780)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ドライアイ / 線維化 / 免疫応答 / 造血幹細胞移植 / T細胞 / 間葉系幹細胞 / 眼免疫 / 涙腺 / 造血幹細胞 / 炎症 / 慢性移植片対宿主病 / 線維芽細胞 / 眼病理学 / 移植片対宿主病

Research Abstract

Chronic ocular graft-versus-host disease(GVHD), i.e. chronic GVHD related dry eye, is a major complication after allogeneic hematopoietic stem cell transplantation. We have found that donor-derived mesenchymal stem cells play a significant role for underlying mechanism of chronic ocular GVHD fibrosis. We have found donor MSCs engrafted GVHD target organs such as lacrimal gland, conjunctiva, salivary gland, lung, skin, liver and intestine. We also suggested that donor MSCs interacted with T cells in the pathogenic regions and contributed to the onset of cGVHD and chronicity of this disease. We further showed donor MSCs increased IL-6 leading to decreased Tregs and conversely an increase in Th 17 cells in peripheral blood. Our results show that donor MSCs trigger immune responses in T cells and immune mediated fibrosis of chronic ocular GVHD.

Research Products

• [Journal Article] 小児のドライアイ (2014)
  • Author(s): 小川葉子
  • Journal Title: 小児科 Volume: 3 Pages: 287-295
  • NAID: 40020013345
• [Journal Article] International chronic ocular graft-vs-host-disease (GVHD) consensus group: Proposed diagnostic criteria for chronic GVHD (Part I) (2013)
  • Author(s): Ogawa Y, Kim SK, Dana R, Clayton J, Jain S, Rosenblatt MI, Perez VL, Shikari H, Riemens A, Tsubota K. International chronic ocular graft-vs-host-disease (GVHD) consensus group: Proposed diagnostic criteria for chronic GVHD (Part I).
  • Journal Title: Sci Rep Volume: 3 Issue: 1 Pages: 3419-3419
  • DOI: 10.1038/srep03419
  • Peer Reviewed
• [Journal Article] Dry eye disease and inflammation (Review Article) (2013)
  • Author(s): Ogawa Y, Tsubota K
  • Journal Title: Inflamm Regen Volume: 33(5) Pages: 238-48
  • URL: https://www.jstage.jst.go.jp/article/inflammregen/33/5/33_238/_pdf
  • Peer Reviewed
• [Journal Article] Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease. (2013)
  • Author(s): Kawai M, Ogawa Y, Shimmura S, Ohta S, Suzuki T, Kawamura N, Kuwana M, Kawakami Y, Tsubota K.
  • Journal Title: Sci Rep Volume: 3 Issue: 1 Pages: 2455-2455
  • DOI: 10.1038/srep02455
  • Peer Reviewed
• [Journal Article] Angiotensin II type 1 receptor antagonist attenuates lacrimal gland, lung, and liver fibrosis in a murine model of chronic graft-versus-host disease. (2013)
  • Author(s): Yaguchi S, Ogawa Y, Shimmura S, Kawakita T, Hatou S, Satofuka S, Nakamura S, Imada T, Miyashita H, Yoshida S, Yaguchi T, Ozawa Y, Mori T, Okamoto S, Kawakami Y, Ishida S, Tsubota K.
  • Journal Title: PLoS ONE Volume: 8 Issue: 6 Pages: e64724-e64724
  • DOI: 10.1371/journal.pone.0064724
  • Peer Reviewed
• [Journal Article] Validation of different sets of criteria for the diagnosis of Sjögren's syndrome in Japanese patients. (2013)
  • Author(s): Tsuboi H
  • Journal Title: Mod Rheumatol. Volume: 23 Issue: 2 Pages: 219-225
  • DOI: 10.1007/s10165-012-0812-9
  • Peer Reviewed
• [Journal Article] Dry eye disease and inflammation. (2013)
  • Author(s): Ogawa Y, Tsubota K. Review Article. 2013 .
  • Journal Title: Inflamm Regen. Volume: 33 Pages: 238-248
  • NAID: 130004482314
  • Peer Reviewed
• [Journal Article] Surgical management of lacrimal punctal cauterization in chronic graft-versus-host fisease related dry eye with recurrent punctal plug extrusion.. (2012)
  • Author(s): Yaguchi S, Ogawa Y, Kamoi M, Uchino M, Tatematsu Y, Ban Y, Ohba E, Okamoto S, Goto E, Tsubota K.
  • Journal Title: Bone Marrow Transplant Volume: 47 Issue: 11 Pages: 1465-1469
  • DOI: 10.1038/bmt.2012.50
  • Peer Reviewed
• [Journal Article] Accumulation of secretory vesicles in the lacrimal gland epithelia is related to non-Sjogren' s type dry eye in visual display terminal users (2012)
  • Author(s): Kamoi M, Ogawa Y, Nakamura S, Dogru M, Nagai T, Obata H, Ito M, Kaido M, Kawakita T, Okada Y, Kawakami Y, Shimmura S, Tsubota K.
  • Journal Title: PLoS One Volume: 7巻 Issue: 9 Pages: 1-8
  • DOI: 10.1371/journal.pone.0043688
  • Peer Reviewed
• [Journal Article] Presence and physiological function of Renin-Angiotensin System in mouse lacrimal gland. (2012)
  • Author(s): Yaguchi S, Ogawa Y, Shimmura S, Hatou S, Nakamura S, Inaba T, Imada T, Ozawa Y, Kawakami Y, Ishida S, Tsubota K.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 53 Issue: 9 Pages: 5416-25
  • DOI: 10.1167/iovs.12-9891
  • Peer Reviewed
• [Journal Article] Oxidative stress induced inflammation initiates functional decline of tear production (2012)
  • Author(s): Uchino Y, Kawakita T, Miyazawa M, Ishii T, Onouchi H, Yasuda K, Ogawa Y, Shimmura S, Ishii N, Tsubota K.
  • Journal Title: PLoS ONE Volume: 7 Issue: 10 Pages: e45805-e45805
  • DOI: 10.1371/journal.pone.0045805
  • Peer Reviewed
• [Journal Article] Age-Related Dysfunction of the Lacrimal Gland and Oxidative Stress : Evidence from the Cu,Zn-Superoxide Dismutase-1 (Sod1) Knockout Mice. (2012)
  • Author(s): Kojima T, Wakamatsu T, Dogru M, Ogawa Y, Igarashi A, Ibrahim O, Inaba T, Shimizu T, Noda S, Obata H, Nakamura S, Wakamatsu A, Shirasawa T, Shimazaki J, Negishi K, Tsubota K
  • Journal Title: Am J Pathol. Volume: 180 Issue: 5 Pages: 1879-1896
  • DOI: 10.1016/j.ajpath.2012.01.019
  • Peer Reviewed
• [Journal Article] Mucosal microvilli in dry eye patients with chronic GVHD (2012)
  • Author(s): Tatematsu Y, Ogawa Y, Shimmura S, Dogru M, Yaguchi S, Nagai T, Yamazaki K, Kameyama K, Okamoto S, Kawakami Y, Tsubota K
  • Journal Title: Bone Marrow Transplant Volume: 47(3) Issue: 3 Pages: 416-425
  • DOI: 10.1038/bmt.2011.89
  • Peer Reviewed
• [Journal Article] Comparison of stem cell sources in the severity of dry eye after allogeneic haematopoietic stem cell transplantation (2012)
  • Author(s): Uchino M, Ogawa Y, Uchino Y, Mori T, Okamoto S, Tsubota K
  • Journal Title: Br J Ophthalmol Volume: 96(1) Issue: 1 Pages: 34-37
  • DOI: 10.1136/bjophthalmol-2011-300514
  • Peer Reviewed
• [Journal Article] Morphologic evaluation of meibomian glands in chronic graft-versus-host disease using in vivo laser confocal microscopy (2011)
  • Author(s): Ban Y, Ogawa Y, Ibrahim OM, Tatematsu Y, Kamoi M, Uchino M, Yaguchi S, Dogru M, Tsubota K
  • Journal Title: Mol Vis (PubMed - indexed for MEDLINE) Volume: 17(2) (PMID : 22025888) Pages: 2533-2543
  • Peer Reviewed
• [Journal Article] Donor-recipient gender difference affects severity of dry eye after hematopoietic stem cell transplantation (2011)
  • Author(s): Kamoi M, Ogawa Y, Uchino M, Tatematsu Y, Mori T, Okamoto S, Tsubota K
  • Journal Title: Eye Volume: 73 Issue: 7 Pages: 860-865
  • DOI: 10.1038/eye.2011.73
  • Peer Reviewed
• [Journal Article] Morphologic evaluation of meibomian glands in chronic graft-versus-host disease using in vivo laser confocal microscopy. (2011)
  • Author(s): Ban Y, Ogawa Y, Ibrahim OM, Tatematsu Y, Kamoi M, Uchino M, Yaguchi S, Dogru M, Tsubota K.(*Corresponding author)
  • Journal Title: Mol Vis. Volume: 17 Pages: 2533-2543
  • Peer Reviewed
• [Journal Article] Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sjogren's syndrome (2011)
  • Author(s): Yoshimoto K., Tanaka M., et al
  • Journal Title: Arthritis Research and Therapy Volume: 13(5) Issue: 5
  • DOI: 10.1186/ar3493
  • Peer Reviewed
• [Journal Article] Generation of stratified squamous epithelial progenitor cells from mouse induced pluripotent stem cells (2011)
  • Author(s): Yoshida S, Yasuda M, Miyashita H, Ogawa Y, Yoshida T, Matsuzaki Y, Tsubota K, Okano H, Shimmura S
  • Journal Title: PLoS One Volume: 6(12) Issue: 12 Pages: 1-1
  • DOI: 10.1371/journal.pone.0028856
  • Peer Reviewed
• [Journal Article] Prevention of cytarabine-induced kerato-conjunctivitis by eye rinse in patients receiving high-dose cytarabine and total body irradiation as a conditioning for hematopoietic stem cell transplantation (2011)
  • Author(s): Mori T, Kato J, Yamane A, Aisa Y, Kawata Y, Ichimura M, Tsuneyama C, Yashima T, Ogawa Y, Tsubota K, Shigematsu N, Shimizu T, Okamoto S
  • Journal Title: Int J Hematol Volume: 94: Issue: 3 Pages: 261-265
  • DOI: 10.1007/s12185-011-0912-x
  • NAID: 10029694317
  • Peer Reviewed
• [Journal Article] Dysfunction of corneas and lacrimal glands in smoking model rat (2011)
  • Author(s): Higuchi A, Ito K, Dogru M, Kitamura M, Kawakita T, Ogawa Y, and Tsubota K
  • Journal Title: Free Rad Biol Med Volume: 51 Issue: 12 Pages: 2210-2216
  • DOI: 10.1016/j.freeradbiomed.2011.09.025
  • Peer Reviewed
• [Presentation] Mismatched mesenchymal stem cells as an initial trigger of ocular chronic graft-versus- host disease following allogeneic bone marrow transplantation (2013)
  • Author(s): Ogawa Y, Shimmura S, Morikawa S, Okano H, Matsuzaki Y, Tsubota K
  • Organizer: The 3rd International Conference on Clinical & Experimental Ophthalmology Hilton Chicago/Northbrook
  • Place of Presentation: USA
  • Year and Date: 2013-04-14
• [Presentation] シェーグレン症候群の臓器病変と腺病変の最前線炎症とドライアイ (2013)
  • Author(s): 小川葉子
  • Organizer: 第22回日本シェーグレン症候群学会学術集会
  • Place of Presentation: 大阪 (シンポジウム1)
• [Presentation] 若手ドライアイ研究者育成プログラム上皮に着目した研究 (2013)
  • Author(s): 小川葉子
  • Organizer: 第7回箱根ドライアイクラブ
  • Place of Presentation: 神奈川
• [Presentation] Donor mesenchymal stem cells expressing MHC class II molecule trigger immune responses in an animal model of lacrimal gland chronic graft-versus-host disease (2013)
  • Author(s): Ogawa Y, Shimmura S, Yaguchi S, Inaba T, Tsubota K
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) Florida
  • Place of Presentation: Florida, USA
• [Presentation] Donor mesenchymal stem cells induce immune response in lacrimal gland chronic graft versus host disease in an animal model (2013)
  • Author(s): Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Sato Y, Suzuki S, Yaguchi T, Inaba, T, Yaguchi S, Okamoto S, Kawakami Y, Okano H, Maztsuzaki Y, Tsubota K
  • Organizer: The 12th International Symposium on Sjögren's Syndrome
  • Place of Presentation: Kyoto , Japan
• [Presentation] Donor mesenchymal stem cells expressing MHC class II molecule trigger immune responses in an animal model of lacrimal gland chronic graft-versus-host disease. (2013)
  • Author(s): Ogawa Y, Shimmura S, Yaguchi S, Inaba T, Tsubota K.
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2013, 5-9 May 2013
  • Place of Presentation: Seattle, USA
• [Presentation] The regeneration potential of mouse lacrimal gland following duct ligation procedure (2013)
  • Author(s): Liu Y, Kawakita T, Sugiyama M, Hirayama M, Kawashima M, Ogawa Y, Ito M, Shimmura S, Tsubota K.
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2013, 5-9 May 2013
  • Place of Presentation: Seattle, USA
• [Presentation] Primary and secondary surveys on epidemiology of Sogren's syndrome in all Japan. (2013)
  • Author(s): Tsuboi H, Asashima H, Umehara H, Kawakami A, Nakamura H, Sano H, Tsubota K, Ogawa Y, Takamura E, Saito I, Inoue H, Nakamura S, Moriyama M, Takeuchi T, Tanaka Y, Hirata S, Mimori T, Ohta A, Matsumoto I, Sumida T.
  • Organizer: The 12th International Symposium on Sjogren's Syndrome
  • Place of Presentation: Kyoto, JAPAN
• [Presentation] Donor mesenchymal stem cells induce immune response in lacrimal gland chronic graft versus host disease in an animal model. (2013)
  • Author(s): Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Sato Y, Suzuki S, Yaguchi T, Inaba, T, Yaguchi S, Okamoto S, Kawakami Y, Okano H, Maztsuzaki Y, Tsubota K.
  • Organizer: The 12th International Symposium on Sjogren's Syndrome
  • Place of Presentation: Kyoto, JAPAN
• [Presentation] International chronic ocular graft versus host disease (GVHD) consensus group: Proposal of new diagnostic criteria for chronic GVHD (Part I). (2013)
  • Author(s): Ogawa Y, Kim SK, Dana R, Clayton J, Jain S, Rosenblatt MI, Perez VL, Shikari H, Riemens A, Tsubota K.
  • Organizer: The 7th International Conference on the Tear Film & Ocular Surface: Basic Science and Clinical Relevance; Taormina, Sicily, Italy. 18-21 Sep 2013
  • Place of Presentation: Taormina, Sicily, Italy.
• [Presentation] Analysis of fibrosis in IgG4-related Mikulicz's disease. (2013)
  • Author(s): Fukui M, Ogawa Y, Shimmura S, Hatou S, Ichihashi Y, Yaguchi S, Hirayama M, Kawakita T, Tsubota K.
  • Organizer: The 7th International Conference on the Tear Film & Ocular Surface: Basic Science and Clinical Relevance; 18-21 Sep 2013
  • Place of Presentation: Taormina, Sicily, Italy.
• [Presentation] Mismatched mesenchymal stem cells as an initial trigger of ocular chronic graft-versus- host disease following allogeneic bone marrow transplantation. (2013)
  • Author(s): Ogawa Y, Shimmura S, Morikawa S, Okano H, Matsuzaki Y, Tsubota K.
  • Organizer: The 3rd International Conference on Clinical & Experimental Ophthalmology
  • Place of Presentation: Chicago/Northbrook, USA
  • Invited
• [Presentation] シンポジウム１ シェーグレン症候群の臓器病変と腺病変の最前線 炎症とドライアイ. (2013)
  • Author(s): 小川 葉子
  • Organizer: 第22回日本シェーグレン症候群学会学術集会.
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 若手ドライアイ研究者育成プログラム 上皮に着目した研究. (2013)
  • Author(s): 小川葉子
  • Organizer: 第7回箱根ドライアイクラブ.
  • Place of Presentation: 神奈川
  • Invited
• [Presentation] ドライアイの話題の最前線 (2012)
  • Author(s): 小川葉子
  • Organizer: 第2回レディースフォーラムin横浜
  • Place of Presentation: 神奈川
  • Year and Date: 2012-09-12
• [Presentation] 自己免疫疾患様の病態を示す慢性移植片対宿主病マウスモデルの検討 (2012)
  • Author(s): 小川葉子
  • Organizer: 第17回シェーグレン症候群セミナー
  • Place of Presentation: 東京
  • Year and Date: 2012-05-19
• [Presentation] Minor antigen-mismatched MSC react with residual host T cells to trigger the progression of chronic GVHD (2012)
  • Author(s): Matsuzaki Y, Ogawa Y, Morikawa S, Okano H, Tsubota K, Shimmura S
  • Organizer: International Society of Stem Cell Research (ISSCR) 10th Annual Meeting
  • Place of Presentation: Yokohama, Japan
• [Presentation] Interaction between donor mesenchymal stem cells and recipient-derived T cells in the pathogenesis of ocular chronic graft versus host disease (2012)
  • Author(s): Ogawa Y, Shimmura S, Morikawa S, Yaguchi T, Yaguchi S, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K
  • Organizer: The association for research in vision and ophthalmology 2012 (ARVO 2012) Annual Meeting
  • Place of Presentation: Fort Lauderdale, Florida, USA
• [Presentation] A role of recipient-derived T cells in ocular chronic graft-versus-host disease (2012)
  • Author(s): Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi Y, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K
  • Organizer: 1st Conference on the Tear Film and Ocular Surface in Asia
  • Place of Presentation: Kanagawa, Japan
• [Presentation] A role of recipient-derived T cells in ocular chronic graft-versus-host disease. (2012)
  • Author(s): Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi Y, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K.
  • Organizer: 1st Conference on the Tear Film and Ocular Surface in Asia,
  • Place of Presentation: Kanagawa, Japan
• [Presentation] Interaction between donor mesenchymal stem cells and recipient-derived T cells in the pathogenesis of ocular chronic graft versus host disease (2012)
  • Author(s): Ogawa Y, Shimmura S, Morikawa S, Yaguchi T, Yaguchi S, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K. .
  • Organizer: The association for research in vision and ophthalmology 2012 (ARVO 2012) Annual Meeting,
  • Place of Presentation: Fort Lauderdale, Florida, USA
• [Presentation] Minor antigen-mismatched MSC react with residual host T cells to trigger the progression of chronic GVHD. (2012)
  • Author(s): Matsuzaki Y, Ogawa Y, Morikawa S, Okano H, Tsubota K, Shimmura S.
  • Organizer: International Society of Stem Cell Research (ISSCR) 10th Annual Meeting,
  • Place of Presentation: Yokohama, Japan.
• [Presentation] 自己免疫疾患様反応を示す眼慢性GVHDマウスモデルのＴ細胞と間葉系幹細胞の相互作用 (2012)
  • Author(s): 小川葉子, 榛村重人, 森川暁, 馬渕洋, 谷口智憲, 谷口紗織, 稲葉隆明, 岡本真一郎, 河上 裕, 岡野栄之, 松崎有未, 坪田一男..
  • Organizer: 第21回日本シェーグレン症候群学会学術集会
  • Place of Presentation: 京都
• [Presentation] 自己免疫疾患様の病態を示す慢性移植片対宿主病マウスモデルの検討. (2012)
  • Author(s): 小川葉子
  • Organizer: 第17回シェーグレン症候群セミナー 2012/5/19
  • Place of Presentation: 東京
  • Invited
• [Presentation] ドライアイの話題の最前線. (2012)
  • Author(s): 小川葉子
  • Organizer: 第2回レディース・アイ・フォーラム in 横浜.
  • Place of Presentation: 横浜
  • Invited
• [Presentation] Donor mesenchymal stem cells trigger chronic graft-versus-host disease following minor antigen-mismatched bone marrow transplantation (2011)
  • Author(s): Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi T, Inaba T, Yaguchi S, Kawakami Y, Okano H, Tsubota K, Matsuzaki Y
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-28
• [Presentation] From Basic Science (2011)
  • Author(s): 小川葉子
  • Organizer: Inflammationとドライアイの接点-基礎研究の本質を見抜く箱根ドライアイクラブ
  • Place of Presentation: 神奈川 (シンポジウム①)
  • Year and Date: 2011-06-24
• [Presentation] A Significant Role of Mesehchymal Stem Cells in Immune Processes and Pathogenic Fibrosis In Ocular Chronic Graft Versus Host Disease (2011)
  • Author(s): Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi T, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO), Annual meeting
  • Place of Presentation: Florida, U.S.A.
  • Year and Date: 2011-05-04
• [Presentation] Lacrimal Gland Inflammation And Fibrosis In Murine Model Of Ocular Graft Versus Host Disease (2011)
  • Author(s): Yaguchi S, Ogawa Y, Shinmura S, Tsubota K
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO), Annual meeting
  • Place of Presentation: Florida, U.S.A.
  • Year and Date: 2011-05-03
• [Presentation] Mucosal Microvilli In Dry Eye Patients With Chronic Graft-versus-host Disease (2011)
  • Author(s): Tatematsu Y, Ogawa Y, Shinmura S, Dogru M, Nagai T, Yaguchi S, Yamazaki K, Kameyama K, Kawakami Y, Tsubota K
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO), Annual meeting
  • Place of Presentation: Florida, U.S.A.
  • Year and Date: 2011-05-03
• [Presentation] A Significant Role of Mesehchymal Stem Cells in Immune Processes and Pathogenic Fibrosis In Ocular Chronic Graft Versus Host Disease (2011)
  • Author(s): Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi T, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K.
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO), Annual Meeting, 2011
  • Place of Presentation: Florida, USA.
• [Presentation] Aquaporin 1 Positive Mesenchymal Cell Imply Existence Of Cornea Limbal Niche Cells. (2011)
  • Author(s): Higa K, Kato N, Yoshida S, Ogawa Y, Shimazaki J, Tsubota K, Shimmura S.
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO), Annual Meeting, 2011
  • Place of Presentation: Florida, USA
• [Presentation] Lacrimal Gland Inflammation And Fibrosis In Murine Model Of Ocular Graft Versus Host Disease. (2011)
  • Author(s): Yaguchi S, Ogawa Y, Shinmura S, Tsubota K.
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO), Annual Meeting, 2011
  • Place of Presentation: Florida, USA
• [Presentation] Role Of Muscarinic Acetylcholine Receptors and Ca2+ Signaling in Tear Secretion. (2011)
  • Author(s): Inaba T, Hisatsune C, Kawakita T, Sasaki Y, Ogawa Y, Mikoshiba K, Tsubota K.
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO), Annual Meeting, 2011
  • Place of Presentation: Florida, USA
• [Presentation] Role Of Intracellular Oxidative Stress In The Mechanism Of The Dry Eye Disease (2011)
  • Author(s): Uchino Y, Kawakita T, Miyazawa M, Ishii T, Onouchi H, Yasuda K, Ogawa Y, Shimmura S, Ishii N, Tsubota K.
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO), Annual Meeting, 2011
  • Place of Presentation: Florida, USA
• [Presentation] Mucosal Microvilli In Dry Eye Patients With Chronic Graft-versus-host Disease (2011)
  • Author(s): Tatematsu Y, Ogawa Y, Shinmura S, Dogru M, Nagai T, Yaguchi S, Yamazaki K, Kameyama K, Kawakami Y, Tsubota K.
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO), Annual Meeting, 2011
  • Place of Presentation: Florida, USA
• [Presentation] Ocular chronic graft-versus-host disease. (2011)
  • Author(s): Ogawa Y, Kamoi M, Uchino M, Ban Y, Yaguchi S, Inagaki E, Tsubota K.
  • Organizer: 1st Ocular cGVHD International Consensus Meeting. KEIO Global Clinical Research Program
  • Place of Presentation: Florida, USA
• [Presentation] ドナー間葉系幹細胞と慢性移植片対宿主病の発症機構/Donor mesenchymal stem cells trigger chronic graft-versus-host disease following minor antigen-mismatched bone marrow transplantation. (2011)
  • Author(s): Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi T, Inaba T, Suzuki S, Yaguchi S, Kawakami Y, Okano H, Tsubota K, Matsuzaki Y.
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 幕張メッセ国際会議場(千葉)
• [Presentation] 眼慢性移植片対宿主病の発症機構におけるドナー間葉系幹細胞の役割 (2011)
  • Author(s): 小川葉子、榛村重人、森川 暁、馬渕 洋、谷口智憲、鈴木禎史、河上 裕、岡野英之、松崎有未、坪田一男
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京)
• [Presentation] 眼移植片対宿主病(GVHD)モデルマウスにおける涙腺の免疫組織学的検討 (2011)
  • Author(s): 谷口紗織、小川葉子、榛村重人、坪田一男
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京)
• [Presentation] 慢性移植片対宿主病症例の涙腺における免疫担当細胞の局在とT細胞の活性化 (2011)
  • Author(s): 林勇海、小川葉子、榛村重人、川北哲也、谷口紗織、岡本真一郎、河上裕、坪田一男
  • Organizer: 慶應義塾大学医学部 第4学年 自主学習発表会
  • Place of Presentation: 慶應義塾大学医学部 北里講堂（東京）
• [Presentation] シンポジウム(1)From Basic Science. Inflammationとドライアイの接点－基礎研究の本質を見抜く (2011)
  • Author(s): 小川葉子
  • Organizer: 箱根ドライアイクラブ(招待講演)
  • Place of Presentation: ヒルトン小田原リゾート 神奈川
• [Presentation] 膠原病と目 (2011)
  • Author(s): 小川葉子
  • Organizer: 全国膠原病友の会 千葉支部 医療講演会(招待講演)
  • Place of Presentation: 我孫子市けやきプラザ（千葉）
• [Book] 13.眼表面疾患とドライアイ慢性移植片対宿主病とドライアイ「専門医のための眼科診療クオリファイ19ドライアイスペシャリストへの道」 (2013)
  • Author(s): 小川葉子
  • Publisher: 中山書店
• [Book] II.臨床編:診断5.眼科からみたGVHD「みんなに役立つGVHD(移植片対宿主病)の基礎と臨床」 (2013)
  • Author(s): 小川葉子
  • Publisher: 医薬ジャーナル
• [Book] ドライアイ「外来で診る眼科疾患」 (2013)
  • Author(s): 小川葉子
  • Publisher: 慶應義塾大学薬学部
• [Book] 専門医のための眼科診療クオリファイ 19 ドライアイスペシャリストへの道 (2013)
  • Author(s): 小川葉子
  • Total Pages: 421
  • Publisher: 中山書店
• [Book] 専門医のための眼科診療クオリファイ 19 ドライアイスペシャリストへの道 (2013)
  • Author(s): 谷口紗織、小川葉子、坪田一男
  • Total Pages: 421
  • Publisher: 中山書店
• [Book] 外来で診る 眼科疾患 (2013)
  • Author(s): 小川葉子
  • Total Pages: 82
  • Publisher: 慶應義塾大学薬学部
• [Book] みんなに役立つGVHD（移植片対宿主病）の基礎と臨床 (2013)
  • Author(s): 小川 葉子
  • Total Pages: 424
  • Publisher: 医薬ジャーナ.ル
• [Book] 眼科と他科との関連疾患「TEXT眼科学」改訂3版 (2012)
  • Author(s): 小川葉子
• [Book] TEXT眼科学 改訂3版 (2012)
  • Author(s): 小川葉子
  • Total Pages: 14
  • Publisher: 南山堂
• [Book] ドライアイリサーチアワード受賞論文ヒト眼慢性移植片対宿主病における上皮間葉転換「Frontiers in dry eye」 6(2) (2011)
  • Author(s): 小川葉子
• [Book] Frontiers in Dry Eye. (2011)
  • Author(s): 小川葉子
  • Total Pages: 92
  • Publisher: メディカルレビュー社
• [Remarks] 研究者プロフィール
  • URL: http://k-ris.keio.ac.jp/Profiles/0150/0021454/profile.html