| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We irradiated ultraviolet onto the cultured corneal epithelial cells with various conditions. Phosphorylation of p38, decrease of E-cadherin, beta-catenin, and upregulation of a transcriptional factor, snail occurred, however, the representative mesenchymal markers were not induced.
We suspected that ultraviolet alone was insufficient for induction. We also assessed the addition of cytokines (TGF-beta and/or TNF-alpha), however the combined stimuli with ultraviolet and cytokines did not success induction of epithelial mesenchymal transition characterized by upregulation of mesenchymal markers.
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