| Project/Area Number |
23592594
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
TAKAGI Hitoshi 聖マリアンナ医科大学, 医学部, 教授 (70283596)
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| Co-Investigator(Kenkyū-buntansha) |
KITAOKA Yasushi 聖マリアンナ医科大学, 医学部, 講師 (10367352)
MUNEMASA Yasunari 聖マリアンナ医科大学, 医学部, 講師 (30440340)
UENO Satoki 聖マリアンナ医科大学, 医学部, 教授 (20109010)
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| Co-Investigator(Renkei-kenkyūsha) |
OGAWA Yoshihiro 東京医科歯科大学, 難治疾患研究所, 教授 (70291424)
TAKAKURA Nobuyuki 大阪大学, 微生物病研究所, 教授 (80291954)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | フェノフィブラート / トロンボモジュリン / PPARα / 血管内皮 |
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| Research Abstract |
Prospective-randomized clinical trials revealed efficacy of fenofibrate, a PPARalpha gonist, in inhibition of diabetic retinopathy development or progression. In this regard, we investigated gene expression and epigenomic profile of PPARalpha - stimulated vascular endothelial cells. Stimulation of PPARalpha showed anti-inflammatory and anti-thrombotic effects in gene expression profile in vascular cells. Epigenomic analyses revealed thrombomodulin is regulated directly under transcriptional regulation of PPARalpha and mediate such gene regulation of inflammatory and pro-thrombotic genes. These findings suggest that thrombomodulin is a key regulator of vascular defense mechanism in diabetic retinopathy and could be applied to future treatment strategies.
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