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The role of the interaction between integrin and TGF-beta in the eye wound healing

Research Project

Project/Area Number 23592596
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionKinki University

Principal Investigator

YOSHIDA Koji  近畿大学, 医学部, 准教授 (60230736)

Co-Investigator(Kenkyū-buntansha) SUGIOKA Koji  近畿大学, 医学部, 講師 (50399119)
HAGIHARA Satoru  近畿大学, 医学部, 講師 (40460852)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords創傷治癒 / インテグリン / 線維芽細胞 / TGF-β / 線維化 / タンパク質 / α2-antiplasmin
Research Abstract

When corneal fibroblast (keratocyte) was stimulated by TGF-beta, the keratocytes showed myofibroblast-like morphology. In addition, the expression of integrin alpha11 (ITGA11), alpha-smooth muscle actin (alpha-SMA), fibronectin in keratocytes was increased by TGF-beta treatment. Sensitivity to TGF-beta was up-regulated in the cells constitutively expressing ITGA11 or calcium-and integrin-binding protein 1. It was suggested that ITGA11 and CIB1 could be the target protein of the organ fibrosis treatment.Furthermore, we found that the green tea component epigallocatechin-3-gallate (EGCG) binds to TGF-beta type II receptor and inhibits the action of TGF-beta.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (9 results)

  • [Journal Article] Interaction of calcium- and integrin-binding protein 1 with integrin α11 and its possible involvement in pulmonary fibrosis2014

    • Author(s)
      Yoshida K, Park AM, Ozaki S, Munakata H.
    • Journal Title

      Advances in Biological Chemistry

      Volume: 4 Issue: 01 Pages: 59-66

    • DOI

      10.4236/abc.2014.41009

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigallocatechin-3-gallate suppresses transforming growth factor-βsignaling by interacting with the transforming growth factor-βtype II receptor2013

    • Author(s)
      Tabuchi M, Hayakawa S, Honda E, Ooshima K, Itoh T, Yoshida K, Park AM, Higashino H, Isemura M, Munakata H
    • Journal Title

      World J Exp Med

      Volume: 3 Issue: 4 Pages: 100-107

    • DOI

      10.5493/wjem.v3.i4.100

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] TGF-β_2 promotes RPE cell invasion into a collagen gel by mediating urokinase-type plasminogen activator (uPA) expression2013

    • Author(s)
      Sugioka K, Kodama A, Okada K, Iwata M, Yoshida K, Kusaka S, Matsumoto C, Kaji H, Shimomura Y
    • Journal Title

      Exp Eye Res

      Volume: 115 Pages: 13-21

    • DOI

      10.1016/j.exer.2013.06.020

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Myofibroblasts: Biochemical and Proteomic Approaches to Fibrosis2013

    • Author(s)
      Honda E, Park AM, Yoshida K, Tabuchi M, Munakata H.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 230 Issue: 2 Pages: 67-73

    • DOI

      10.1620/tjem.230.67

    • NAID

      10031182993

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and alpha2-antiplasmin in human corneal perforation: a case report2012

    • Author(s)
      杉岡 孝二
    • Journal Title

      BMC Ophthalmology

      Volume: 12 Issue: 1

    • DOI

      10.1186/1471-2415-12-60

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Conditioned media from lung cancer cell line A549 and PC9 inactivate pulmonary fibroblasts by regulating protein phosphorylation.2012

    • Author(s)
      Park AM, Hayakawa S, Honda E, Mine Y, Yoshida K, Munakata H.
    • Journal Title

      Arch Biochem Biophys.

      Volume: 15;518(2) Issue: 2 Pages: 133-41

    • DOI

      10.1016/j.abb.2011.12.012

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] TGF-beta2 promotes RPE cell invasion into collagen gel by mediating urokinase-type plasminogen activator (uPA) expression2013

    • Author(s)
      Sugioka K
    • Organizer
      ARVO 2013 Annual Meeting
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2013-05-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 原因不明の角膜潰瘍による角膜穿孔症例における線溶系因子の免疫学的局在の検討2013

    • Author(s)
      児玉彩
    • Organizer
      角膜カンファランス2013(第37回日本角膜学会総会、第29回日本角膜移植学会)
    • Place of Presentation
      和歌山県西牟婁郡白浜町
    • Year and Date
      2013-02-15
    • Related Report
      2013 Final Research Report
  • [Presentation] マトリックスメタロプロテイナーゼ2はα_2-antiplasminを分解する2012

    • Author(s)
      吉田浩二
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡市
    • Year and Date
      2012-12-15
    • Related Report
      2013 Final Research Report
  • [Presentation] L鎖に糖鎖付加が示唆された特異な熱反応性を持つλ型BJPの特性2012

    • Author(s)
      井本真由美
    • Organizer
      第59回日本臨床検査医学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2012-11-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 線溶系遺伝子欠損マウスを用いた角膜上皮創傷治癒過程の検討2012

    • Author(s)
      児玉彩
    • Organizer
      第116回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-05
    • Related Report
      2013 Final Research Report
  • [Presentation] TGF-beta2 promotes RPE cell invasion into collagen gel by mediating urokinase-type plasminogen activator (uPA) expression

    • Author(s)
      Sugioka K, Kodama A, Yoshida K, Okada K, Kusaka S, Matsumoto C, Shimomura Y.
    • Organizer
      ARVO 2013 Annual Meeting
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 線溶系遺伝子欠損マウスを用いた角膜上皮創傷治癒過程の検討

    • Author(s)
      児玉 彩
    • Organizer
      第116回日本眼科学会総会
    • Place of Presentation
      東京(東京国際フォーラム)
    • Related Report
      2012 Research-status Report
  • [Presentation] L鎖に糖鎖付加が示唆された特異な熱反応性を持つλ型BJPの特性

    • Author(s)
      井本 真由美
    • Organizer
      第59回日本臨床検査医学会学術集会
    • Place of Presentation
      京都市
    • Related Report
      2012 Research-status Report
  • [Presentation] マトリックスメタロプロテイナーゼ2はα2-antiplasminを分解する

    • Author(s)
      吉田 浩二
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡市
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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