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Studies on the pathogenesis and anti-VEGF treatment of retinopathy of prematurity

Research Project

Project/Area Number 23592597
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionKinki University

Principal Investigator

KUSAKA Shunji  近畿大学, 医学部附属病院, 教授 (60260387)

Co-Investigator(Kenkyū-buntansha) KUNIYOSHI Kazuki  近畿大学, 医学部附属病院, 講師 (30234470)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords未熟児網膜症 / 血管内皮細胞増殖因子 / 血管新生 / 抗体治療 / 抗VEGF治療 / サイトカイン / VEGF / 硝子体 / 抗VRGF治療
Research Abstract

Serum samples were collected from 11 infants with ROP who had received intravitreal bevacizumab injection before and 1 day, 1 week, and 2 weeks after the injection. The serum concentrations of bevacizumab and VEGF were measured by enzyme-linked immunosorbent assay. As a result, the serum concentration of bevacizumab before and 1 day, 1week, and 2 weeks after a total of 0.5 mg of intravitreal bevacizumab was 0, 195, 946L, and 1214 (ng/mL), respectively. The serum concentration of VEGF before and 1 day, 1 week, and 2 weeks after a totalof 0.5 mg intravitreal bevacizumab was 1628, 427, 246, and 269 (pg/mL), respectively. There was a significant negative correlation (r= 0.575, P=0.0125) between the serum concentration of bevacizumab and VEGF. These results indicate that bevacizumab can escape from the eye into the systemiccirculation and reduce the serum level of VEGF in infants with ROP.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (77 results)

All 2014 2013 2012 2011

All Journal Article (18 results) (of which Peer Reviewed: 15 results) Presentation (48 results) (of which Invited: 10 results) Book (11 results)

  • [Journal Article] Combined treatment for Coats' disease : retinal laser photocoagulation combined with intravitreal bevacizumab injection was effective in two cases2014

    • Author(s)
      Kodama A, Sugioka K, Kusaka S, Matsumoto C, Shimomura Y
    • Journal Title

      BMC Ophthalmol

      Volume: 14 Pages: 36-36

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal injection of bevacizumab for retinopathy of prematurity2014

    • Author(s)
      Kuniyoshi K, Sugioka K, Sakuramoto H, Kusaka S, Wada N, Shimomura Y
    • Journal Title

      Jpn J Ophthalmol

      Volume: (Epub ahead of print)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescein angiographic observations of peripheral retinal vessel growth in infants after intravitreal injection of bevacizumab as sole therapy for zone I and posterior zone II retinopathy of prematurity2014

    • Author(s)
      Tahija SG, Hersetyati R, Lam GC, Kusaka S, McMenamin PG
    • Journal Title

      Br J Ophthalmol

      Volume: 98(4) Pages: 507-12

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Short-term Postoperative Perfluoro-n-octane Tamponade for Pediatric Complex Retinal Detachment2014

    • Author(s)
      Imaizumi A, Kusaka S, Noguchi H, Shimomura Y, Sawaguchi S
    • Journal Title

      Am J Ophthalmol

      Volume: 157(2)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Short-term Postoperative Perfluoro-n-octane Tamponade for Pediatric Complex Retinal Detachment.2014

    • Author(s)
      Imaizumi A, Kusaka S,
    • Journal Title

      Am J Ophthalmol

      Volume: 57(2) Issue: 2 Pages: 384-389

    • DOI

      10.1016/j.ajo.2013.10.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TGF-β2 promotes RPE cell invasion into a collagen gel by mediating urokinase-type plasminogen activator (uPA) expression2013

    • Author(s)
      Sugioka K, Kodama A, Okada K, Iwata M, Yoshida K, Kusaka S, Matsumoto C, Kaji H, Shimomura Y
    • Journal Title

      Exp Eye Res

      Volume: 115C Pages: 13-21

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variants of FZD4 and LRP5 genes in patients with advanced retinopathy of prematurity2013

    • Author(s)
      Kondo H, Kusaka S, Yoshinaga A, Uchio E, Tawara A, Tahira T
    • Journal Title

      Mol Vis

      Volume: 19 Pages: 476-85

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] TGF-β_2 promotes RPE cell invasion into a collagen gel by mediating urokinase-type plasminogen activator (uPA) expression2013

    • Author(s)
      Sugioka K, Kodama A, Okada K, Iwata M, Yoshida K, Kusaka S, Matsumoto C, Kaji H, Shimomura Y
    • Journal Title

      Exp Eye Res

      Volume: 115 Pages: 13-21

    • DOI

      10.1016/j.exer.2013.06.020

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自傷行為のある知的障害者の白内障と網膜剥離の手術2013

    • Author(s)
      永原 幸、日下俊次、大島佑介、池田恒彦、井上 真
    • Journal Title

      眼科手術

      Volume: 26(3) Pages: 437-443

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 日本眼科学会総集会プログラム委員会に対する評価委員会から2013

    • Author(s)
      日下俊次
    • Journal Title

      日眼会誌

      Volume: 117(3) Pages: 311-314

    • NAID

      10031155930

    • Related Report
      2013 Annual Research Report
  • [Journal Article] アリピプラゾールによる一過性の近視化の1例2013

    • Author(s)
      6. 岡本紀夫 日下俊次 長井紀章 伊藤吉將 下村嘉一
    • Journal Title

      眼科臨床紀要

      Volume: 6(11) Pages: 903-905

    • NAID

      40019868875

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Serum concentrations of bevacizumab (avastin) and vascular endothelial growth factor in infants with retinopathy of prematurity.2012

    • Author(s)
      Sato T, Wada K, Arahori H, Kuno N, Imoto K, Iwahashi-Shima C, Kusaka S
    • Journal Title

      Am J Ophthalmol

      Volume: 153 Issue: 2 Pages: 327-333

    • DOI

      10.1016/j.ajo.2011.07.005

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 重症未熟児網膜症に対する抗VEGF治療2012

    • Author(s)
      日下俊次
    • Journal Title

      日本未熟児新生児学会雑誌

      Volume: 24 Pages: 1-4

    • NAID

      10030827305

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term follow-up after vitrectomy to treat idiopathic full-thickness macular holes: visual acuity and macular complications2012

    • Author(s)
      Sakaguchi H, Ohji M, Oshima Y, Ikuno Y, Gomi F, Maeda N, Kamei M, Kusaka S, Nishida K.
    • Journal Title

      Clin Ophthalmology

      Volume: 6 Pages: 1281-1286

    • DOI

      10.2147/opth.s34629

    • NAID

      120006546343

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intraocular Pressure Elevation Is a Delayed-onset Complication after Successful Vitrectomy for Stages 4 and 5 Retinopathy of Prematurity2012

    • Author(s)
      Iwahashi-Shima C, Miki A, Hamasaki T, Otori Y, Matsushita K, Kiuchi Y, Okada M, Kusaka S.
    • Journal Title

      Retina

      Volume: 32(8) Issue: 8 Pages: 1636-42

    • DOI

      10.1097/iae.0b013e3182551c54

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum Concentrations of Bevacizumab (Avastin®) and Vascular Endothelial Growth Factor in Infants with Retinopathy of Prematurity2012

    • Author(s)
      Sato T, et al.
    • Journal Title

      Am J Ophthalmol

      Volume: 153 Pages: 327-333

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detection of photoreceptor disruption by adaptive optics imaging and Fourier-domain optical coherence tomography in eyes with occult macular dustrophy2011

    • Author(s)
      Kitaguchi Y, et al.
    • Journal Title

      Clin Ophthalmol

      Volume: 5 Pages: 345-51

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mutations in the TSPAN12 Gene in Japanese Patients with Familial Exudative Vitreoretinopathy2011

    • Author(s)
      Kondo H, et al.
    • Journal Title

      Am J Ophthalmol

      Volume: 151 Pages: 1095-1100

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 小児網膜疾患に対する外科的治療2013

    • Author(s)
      日下俊次
    • Organizer
      第34回産業医大眼科研究会
    • Place of Presentation
      北九州市
    • Year and Date
      2013-11-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 小児における網膜硝子体手術2013

    • Author(s)
      日下俊次
    • Organizer
      第43回RETINAの会
    • Place of Presentation
      横浜市
    • Year and Date
      2013-11-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 小児眼科「ベバシズマブ硝子体注射とPDTを施行した小児に発症した網膜血管腫の1例」2013

    • Author(s)
      馬場高志, 三宅敦子, 山崎厚志, 日下俊次, 井上幸次
    • Organizer
      第67回日本臨床眼科学会
    • Place of Presentation
      横浜 (学術展示)
    • Year and Date
      2013-11-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 一般講演眼内レンズ「2つのマーキング法によるトーリック眼内レンズ軸ずれの検討」2013

    • Author(s)
      立花都子, 日下俊次, 小池英子, 河本庄平, 青松圭一, 藤井明子, 檜垣史郎, 下村義一
    • Organizer
      第67回日本臨床眼科学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-11-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 一般講演網膜手術「広角眼底観察システム用曇り防止装置の開発」2013

    • Author(s)
      日下俊次, 下村嘉一
    • Organizer
      第67回日本臨床眼科学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-31
    • Related Report
      2013 Final Research Report
  • [Presentation] 小児網膜手術tips and pearls2013

    • Author(s)
      日下俊次
    • Organizer
      第7回琵琶湖眼底疾患研究会
    • Place of Presentation
      大津市
    • Year and Date
      2013-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 小児網膜硝子体疾患の治療2013

    • Author(s)
      日下俊次
    • Organizer
      第69回Tokyo Ophthalmology Club
    • Place of Presentation
      東京都
    • Year and Date
      2013-06-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 小児網膜硝子体疾患の治療2013

    • Author(s)
      日下俊次
    • Organizer
      第58回山陰眼科集談会
    • Place of Presentation
      出雲市
    • Year and Date
      2013-06-16
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 小児網膜硝子体疾患の治療2013

    • Author(s)
      日下俊次
    • Organizer
      第96回阪大眼科同窓会学術講演会
    • Place of Presentation
      大阪市
    • Year and Date
      2013-06-02
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 小児網膜硝子体疾患の治療2013

    • Author(s)
      日下俊次
    • Organizer
      豊中市眼科医会学術研究会
    • Place of Presentation
      豊中市
    • Year and Date
      2013-04-20
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Vitrectomy and Bevacizumab for Severe Retinopathy of Prematurity2013

    • Author(s)
      Shunji Kusaka
    • Organizer
      The 8^<th> Asia Pacific Vitreo-retina Society Congress
    • Place of Presentation
      Nagoya (Symposium 5)
    • Related Report
      2013 Final Research Report
  • [Presentation] Occurrence of Retinal Datachment in Japanese Patients with Stickler Syndrome2013

    • Author(s)
      Kondo H,Hayashi T,Kondo M,Ohji M,Kusaka S
    • Organizer
      American Academy of Ophthalmology AnnualMeeting
    • Place of Presentation
      New Orleans, LO, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Surgical Treatment of Complex Retinal Detachment2013

    • Author(s)
      ShunjiKusaka
    • Organizer
      The 2^<nd> Annual Meeting of Taiwan Retina Society
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2013 Final Research Report
  • [Presentation] Subretinal drainage and vitrectomy are helpful in diagnosing and treating eye with advanced Coats's disease2013

    • Author(s)
      Imaizumi A, Noguchi H, Kusaka S
    • Organizer
      Singapore National Eye Centre (SNEC) and AAPOS Joint Meeting
    • Place of Presentation
      Singapore
    • Related Report
      2013 Final Research Report
  • [Presentation] (ア)未熟児網膜症に対するベバシズマブ単独治療の成績(イ)硝子体手術が診断と治療に有用であった重症コーツ病の1症例(ウ)前房内に迷入した空気により瞳孔ブロックを来した小児の1例2013

    • Author(s)
      日下俊次
    • Organizer
      第69回日本弱視斜視学会総会第38回日本小児眼科学会総会合同学会
    • Place of Presentation
      広島国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] TGF-beta2 promotes RPE cell invasion into collagen gel by mediating urokinase-type plasminogen activator (uPA) expression2013

    • Author(s)
      Sugioka K, Kodama A, Yoshida K, Okada K, Kusaka S, Matsumoto C, Shimomura Y
    • Organizer
      2013 Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Seatle, WA, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Comparison of surgical results between intrascleral posterior chamber intraocular lens (PC-IOL) fixation and transscleral suturing of PC-IOL in eyes without capsular support2013

    • Author(s)
      Kusaka S, Komoto S, Fujii A, Aomatsu K, Koike E, Tchibana K, Higaki S, Shimomura Y
    • Organizer
      2013 Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Seatle, WA, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Efficacy of short-term postoperative PFO tamponade in pediatric complex retinal detachment2013

    • Author(s)
      Kusaka S
    • Organizer
      The Vail Vitrectomy 2013 Meeting
    • Place of Presentation
      Vail, CO
    • Related Report
      2013 Final Research Report
  • [Presentation] Comparison of surgical results between intrascleral posterior chamber intraocular lens (PC-IOL) fixation and transscleral suturing of PC-IOL in eyes without capsular support.2013

    • Author(s)
      Kusaka S
    • Organizer
      2013 Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Seatle, WA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小児網膜硝子体疾患の治療2013

    • Author(s)
      日下俊次
    • Organizer
      第69回 Tokyo Ophthalmology Club
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 未熟児網膜症に対するベバシズマブ単独治療の成績・硝子体手術が診断と治療に有用であった重症コーツ病の1症例2013

    • Author(s)
      日下 俊次
    • Organizer
      第38回 日本小児眼科学会総会
    • Place of Presentation
      広島市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Subretinal drainage and vitrectomy are helpful in diagnosing and treating eye with advanced Coats’s disease2013

    • Author(s)
      Imaizumi A, Noguchi H, Kusaka S
    • Organizer
      Singapore National Eye Centre (SNEC) and AAPOS Joint Meeting
    • Place of Presentation
      Singapore
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小児網膜手術 tips and pearls2013

    • Author(s)
      日下俊次
    • Organizer
      第7回琵琶湖眼底疾患研究会
    • Place of Presentation
      大津市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 網膜手術  「広角眼底観察システム用曇り防止装置の開発」2013

    • Author(s)
      日下俊次
    • Organizer
      第67回 日本臨床眼科学会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 眼内レンズ 「2つのマーキング法によるトーリック眼内レンズ軸ずれの検討」2013

    • Author(s)
      立花都子 日下俊次 小池英子 河本庄平 青松圭一 藤井明子 檜垣史郎 下村義一
    • Organizer
      第67回 日本臨床眼科学会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 「網膜剥離ファイトクラブ~新しいアプローチの検証~」2013

    • Author(s)
      喜多美穂里 栗山昌治 塚原康友 日下俊次 木村英也 小堀 朗 大澤俊介  竹内忍
    • Organizer
      第67回 日本臨床眼科学会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小児における網膜硝子体手術2013

    • Author(s)
      日下俊次
    • Organizer
      16. 第43回 RETINAの会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Surgical Treatment of Complex Retinal Detachment2013

    • Author(s)
      Keynote Lecture, Shunji Kusaka
    • Organizer
      The 2nd Annual Meeting of Taiwan Retina Society
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Occurrence of Retinal Datachment in Japanese Patients with Stickler Syndrome2013

    • Author(s)
      Kondo H,Hayashi T,Kondo M,Ohji M,Kusaka S
    • Organizer
      American Academy of Ophthalmology Annual Meeting
    • Place of Presentation
      New Orleans,LO,USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小児網膜疾患に対する外科的治療2013

    • Author(s)
      日下俊次
    • Organizer
      第34回 産業医大眼科研究会
    • Place of Presentation
      北九州市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Vitrectomy and Bevacizumab for Severe Retinopathy of Prematurity.2013

    • Author(s)
      Shunji Kusaka:
    • Organizer
      The 8th Asia Pacific Vitreo-retina Society Congress
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ランチョンセミナー DMEアップデート 糖尿病黄斑浮腫に対する硝子体手術の成績2012

    • Author(s)
      日下俊次
    • Organizer
      第35回 日本眼科手術学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] モーニングセミナー 広がる選択肢! 577nmイエローパターンスキャンレーザーの適応577nmイエローパターンスキャンレーザーの使用経験2012

    • Author(s)
      日下俊次
    • Organizer
      第35回 日本眼科手術学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ランチョンセミナー 徹底理解! 激変する硝子体手術を取り巻く環境 Vitrectomy: History & Cutting edge -Stellaris® PC-2012

    • Author(s)
      日下俊次
    • Organizer
      第35回 日本眼科手術学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ランチョンセミナー  網膜疾患に対する最新レーザー治療 -イエローパターンスキャンとマイクロパルス閾値下凝固-577nmイエローパターンスキャンレーザーの使用経験2012

    • Author(s)
      日下俊次
    • Organizer
      第116回日本眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Intraocular Pressure Elevation Is A Delayed-onset Complication After Successful Vitrectomy For Stages 4 And 5 Retinopathy Of Prematurity.2012

    • Author(s)
      Kusaka S, Iwahashi-Shima C, Miki A, Matsushita K, Hamasaki T, Otori Y, Kiuchi Y, Okada M.
    • Organizer
      2012 Association for Research in Vision and Ophthalmology Meeting
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2012 Research-status Report
  • [Presentation] Peters奇形を伴った未熟児網膜症に対する治療2012

    • Author(s)
      南 毅、国吉一樹、日下俊次、櫻本宏之、福田昌彦、松本長太、伊藤久太郎、下村嘉一
    • Organizer
      第68回 日本弱視斜視学会総会・第37回日本小児眼科学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Research-status Report
  • [Presentation] RetCam IIIの紹介と実際2012

    • Author(s)
      日下俊次
    • Organizer
      第68回 日本弱視斜視学会総会・第37回日本小児眼科学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Research-status Report
  • [Presentation] 未熟児網膜症(ROP)に対するベバシズマブ(アバスチン®)投与2012

    • Author(s)
      日下俊次
    • Organizer
      第66回日本臨床眼科学会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Comparison of Outcomes of Vitrectomy for Stage 4A ROP With or Without Preoperative Bevacizumab2012

    • Author(s)
      Kusaka S, Kuniyoshi K, Shima C, Abe K, Shimomura Y.
    • Organizer
      2012 Joint Meeting of the American Academy of Ophthalmology and the Asia-Pacific Academy of Ophthalmology
    • Place of Presentation
      Chicago
    • Related Report
      2012 Research-status Report
  • [Presentation] Genetic Variants of FZD4 Gene in Eyes with Advanced Retinopathy of Prematurity2012

    • Author(s)
      Kondo H, Kusaka S, Yoshinaga A, Uchio E, Tawara A, Tahira T.
    • Organizer
      第51回日本網膜硝子体学会総会
    • Place of Presentation
      甲府市
    • Related Report
      2012 Research-status Report
  • [Presentation] Laser and Avastin for ROP: indications and risks2012

    • Author(s)
      Kusaka S.
    • Organizer
      The 8th International Symposium of Ophthalmology &#8211; Hong Kong
    • Place of Presentation
      Hong Kong
    • Related Report
      2012 Research-status Report
  • [Presentation] Laser and Avastin for ROP: indications and risks2012

    • Author(s)
      Shunji Kusaka
    • Organizer
      Frankfurt Retina Meeting 2012(招待講演)
    • Place of Presentation
      Frankfurt, Germany
    • Related Report
      2011 Research-status Report
  • [Presentation] Shunji Kusaka: Is there still a reason to open the conjunctiva?2011

    • Author(s)
      Shunji Kusaka
    • Organizer
      Leuven Retina Meeting(招待講演)
    • Place of Presentation
      Leuven, Belgium
    • Related Report
      2011 Research-status Report
  • [Presentation] Recent techniques for the treatment of complex retinal detachment.2011

    • Author(s)
      Shunji Kusaka
    • Organizer
      第16次中華眼科学会全国年回(招待講演)
    • Place of Presentation
      広州、中華人民共和国
    • Related Report
      2011 Research-status Report
  • [Presentation] Small-gauge (23g) vitrectomy with a New Generation Phaco & Vitrectomy System: Associate®2011

    • Author(s)
      Shunji Kusaka
    • Organizer
      2011年中華民國眼科醫學會100年年會Lunch Symposium(招待講演)
    • Place of Presentation
      台北
    • Related Report
      2011 Research-status Report
  • [Presentation] Serum Levels of bevacizumab and Vascular Endothelial Growth Factor in Infant With ROP2011

    • Author(s)
      Sato T, et al.
    • Organizer
      2011 American Academy of Ophthalmology Meeting
    • Place of Presentation
      Orlando, FL,USA
    • Related Report
      2011 Research-status Report
  • [Presentation] 教育講演:重症未熟児網膜症に対する抗VEGF治療2011

    • Author(s)
      日下俊次
    • Organizer
      第56回日本未熟児新生児学会・学術集会(招待講演)
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Book] 未熟児網膜症眼科疾患最新の治療2013

    • Author(s)
      日下俊次
    • Publisher
      南江堂
    • Related Report
      2013 Final Research Report
  • [Book] 第一次硝子体過形成遺残専門医のための眼科診療クオリファイ裂孔原性網膜剥離–How to treat2013

    • Author(s)
      日下俊次
    • Publisher
      中山書店
    • Related Report
      2013 Final Research Report
  • [Book] 未熟児網膜症 眼科疾患 最新の治療2013

    • Author(s)
      日下俊次
    • Publisher
      南江堂
    • Related Report
      2013 Annual Research Report
  • [Book] 第一次硝子体過形成遺残 専門医のための眼科診療クオリファイ 裂孔原性網膜剥離 –How to treat2013

    • Author(s)
      日下俊次
    • Publisher
      中山書店
    • Related Report
      2013 Annual Research Report
  • [Book] 網膜硝子体手術 SOS2012

    • Author(s)
      日下俊次
    • Total Pages
      2
    • Publisher
      医学書院
    • Related Report
      2012 Research-status Report 2011 Research-status Report
  • [Book] 眼科診療クオリファイ9 こどもの眼と疾患2012

    • Author(s)
      日下俊次
    • Total Pages
      6
    • Publisher
      中山書店
    • Related Report
      2012 Research-status Report 2011 Research-status Report
  • [Book] あたらしい眼科 292012

    • Author(s)
      日下俊次
    • Total Pages
      5
    • Publisher
      メディカル葵出版
    • Related Report
      2012 Research-status Report
  • [Book] 周産期医学2012

    • Author(s)
      日下俊次
    • Total Pages
      4
    • Publisher
      東京医学社
    • Related Report
      2012 Research-status Report
  • [Book] 症例から学ぶ 周産期診療ワークブック2012

    • Author(s)
      日下俊次
    • Total Pages
      5
    • Publisher
      メジカルビュー社
    • Related Report
      2012 Research-status Report
  • [Book] 新生児の臨床検査・基準値ディクショナリー2012

    • Author(s)
      日下俊次
    • Total Pages
      6
    • Publisher
      メディカ出版
    • Related Report
      2012 Research-status Report
  • [Book] 未熟児網膜症、ビデオセミナー硝子体手術 トップサージャンの極意を学ぶ2011

    • Author(s)
      日下俊次
    • Total Pages
      4
    • Publisher
      メジカルビュー社
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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