Identification of disease marker for dry eye syndrome by comprehensive analysis of tear components
| Project/Area Number |
23592600
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | 独立行政法人国立病院機構(東京医療センター臨床研究センター) |
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Principal Investigator |
YAMADA Masakazu 独立行政法人国立病院機構(東京医療センター臨床研究センター), 視覚研究部, 研究員 (50210480)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 蛋白質 / プロテオーム / 分析化学 / 生体分子 / 脂質 / 生化学 / 涙液 / 角膜 / ドライアイ / ムチン |
|---|
| Research Abstract |
This study was undertaken to identify disease-specific marker for dry eye syndrome by comprehensive analysis of tear components. Tear samples were collected by Schirmer test strips. Major tear proteins including secretory IgA, lactoferrin, lipocalin-1, lysozyme and sialic acid, as a marker of secretory mucins, were measured by high performance liquid chromatography. In aqueous deficiency type dry eye, levels of sialic acid in tears of patients were significantly lower than those of normal controls. Treatment with topical application of diquafosol significantly increased sialic acid levels in tears of those patients. In patients with contact lens-induced dry eye, levels of sialic acid in tears were about the same as those of normal controls. Sialic acid in tears may be a good candidate for disease-specific marker for dry eye syndrome, especially for aqueous deficiency type dry eye.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Classification of secondary corneal amyloidosis and involvement of lactoferrin.2013
Author(s)
Kaoru Araki-sasaki, Koji Hirano, Yasuhiro Osakabe, Masahiko Kuroda, Kazuko Kitagawa, Hiroshi Mishima, Hiroto Obata, Masakazu Yamada, Naoyuki Maeda, Kohji Nishida, Shigeru Kinoshita.
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Journal Title
Ophthalmology
Volume: 120
Issue: 6
Pages: 1166-1172
DOI
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Peer Reviewed
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[Journal Article] Cost-effectiveness of cataract surgery in Japan2011
Author(s)
Hiratsuka Y, Yamada M, Murakami A, Okada AA, Yamashita H, Ohashi Y, Yamagishi N, Tamura H, Fukuhara S, Takura T, Eye Care Comparative Effectiveness Research Team (ECCERT)
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Journal Title
Jpn J Ophthalmol
Volume: 55
Pages: 333-342
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Peer Reviewed
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[Presentation] 涙液浸透圧2011
Author(s)
重安千花、山田昌和
Organizer
第65回日本臨床眼科学会
Place of Presentation
東京 (シンポジウム)
Year and Date
2011-10-28
Related Report
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