Early detection of macular dystrophies by Fourier-domain OCT
| Project/Area Number |
23592601
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | 独立行政法人国立病院機構(東京医療センター臨床研究センター) |
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Principal Investigator |
TSUNODA Kazushige 独立行政法人国立病院機構(東京医療センター臨床研究センター), 視覚研究部, 部長 (30255525)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 黄斑ジストロフィー / OCT / 光干渉断層計 |
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| Research Abstract |
The OCT could demonstrate characterisitic photoreceptor abnormalities in patients with the Occult macular dystrophy (OMD) with RP1L1 mutation; disappearance of cone outer segment tip (COST) line, and blurring or disruption of photoreceptor inner segment ellipsoid (ISe). These finding could be also observed in patients without subjective visual disturbance.
In most of the patients without the RP1L1 mutation, the OCT features were different from the above findings. Patients with OMD, who were electrophysiologically diagnosed, may harbor various etiologies other than the RP1L1 gene mutation and new diagnostic criteria should be established.
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Report
(4 results)
Research Products
(78 results)
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[Journal Article] A Longitudinal Study of Stargardt Disease: Clinical and Electrophysiologic Assessment, Progression, and Genotype Correlations.2013
Author(s)
Fujinami K, Lois N, Davidson AE, Mackay DS, Hogg CR, Stone EM, Tsunoda K, Tsubota K, Bunce C, Robson AG, Moore AT, Webster AR, Holder GE, Michaelides M
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Journal Title
Am J Ophthalmol
Volume: 印刷中
Issue: 6
Pages: 1075-88
DOI
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Peer Reviewed
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[Journal Article] he Clinical Effect of Homozygous ABCA4 Alleles in 18 Patients2013
Author(s)
Fujinami K, Sergouniotis PI, Davidson AE, Mackay DS, Tsunoda K, Tsubota K, Robson AG, Holder GE, Moore AT, Michaelides M, and Webster AR
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Journal Title
Ophthalmology
Volume: 印刷中
Related Report
Peer Reviewed
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[Journal Article] Clinical characteristics of occult macular dystrophy in family with mutation of RP1L1 gene2012
Author(s)
Tsunoda K, Usui T, Hatase T, Yamai S, Fujinami K, Hanazono G, Shinoda K, Ohde H, Akahori M, Iwata T, and Miyake Y
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Journal Title
Retina
Volume: 32(6)
Pages: 1135-1147
Related Report
Peer Reviewed
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[Journal Article] Clinical characteristics of occult macular dystrophy in family with mutation of RP1L1 gene2012
Author(s)
Tsunoda K, Usui T, Hatase T, Yamai S, Fujinami K, Hanazono G, Shinoda K, Ohde H, Akahori M, Iwata T, and Miyake Y
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Journal Title
Retina
Volume: Mar 29. Epub
Related Report
Peer Reviewed
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[Presentation] オカルト黄斑ジストロフィー(Occult Macular Dystrophy)の原因遺伝子解明2011
Author(s)
赤堀正和, 角田和繁, 三宅養三, 福田陽子, 石浦浩之, 辻省次, 臼井知聡, 畑瀬哲尚, 中村誠, 大出尚郎, 板橋剛, 岡本はる, 岩田岳
Organizer
第115回日本眼科学会総会
Place of Presentation
東京
Year and Date
2011-05-13
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[Presentation] Transcorneal electrical stimulation on eyes with no light perception2011
Author(s)
Shinoda K, Ozeki N, Ohde H, Matsumoto CS, Inoue M, Tsunoda K, Inomata K, Kimura I, Mizota A
Organizer
International Society for Clinical Electrophysiology of Vision (ISCEV), 49th Symposium
Place of Presentation
Quebec City, Canada
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[Presentation] Long-term follow-up of four Japanese patients with KCNV2-related retinopathy
Author(s)
Nakamura N, Tsunoda K, Fujinami K, Shinoda K, Akahori M, Iwata T, Tomita K, Hatase T, Usui T, and Miyake Y
Organizer
International Society for Clinical Electrophysiology of Vision, 50th Symposium
Place of Presentation
Valencia, Spain
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