Comprhensive examination for serum autoantigens in endogenous uveitis patients

• Project/Area Number: 23592602
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Hokkaido University
• Principal Investigator: OHNO Shigeaki 北海道大学, -, 名誉教授 (50002382)
• Co-Investigator(Kenkyū-buntansha): ISHIDA Susumu 北海道大学, 大学院研究科, 教授 (10245558) ; NAMBA Kenichi 北海道大学, 大学病院, 講師 (70333599) ; KITAICHI Nobuyoshi 北海道大学, 医学研究科, 客員准教授 (40431366) ; MEGURO Akira 横浜市立大学, 医学研究科, 特任助教 (60508802)
• Co-Investigator(Renkei-kenkyūsha): MIZUKI Nobuhisa 横浜市立大学, 医学研究科, 教授 (90336579) ; SAWASAKI Tatsuya 愛媛大学, 無細胞生命科学工学研究 センター, 准教授 (50314969)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: ぶどう膜炎 / ベーチェット病 / 原田病 / 自己抗体 / 内因性ぶどう膜炎 / 難治性内因性ぶどう膜炎 / 網羅的解析 / バイオインフォマティクス解析 / バイオマーカー

Research Abstract

In this study, serum autoantigens were examined comprhensively in the patients with endogenous uveitis by using our novel detection system.Serum samples were divided into 3 pooled groups.
Among Vogt-Koyanagi-Harada disease patients, 10 kinds of proteins were elevated more than one-and-a-half levels compared with healthy volunteers in sera. Behcet's disease patients also showed that 6 kinds of serum proteins were increased levels by half compared with those of healthy subjects.
We further demonstarted that 3 of these elevated proteins were common to Vogt-Koyanagi-Harada disease and Behcet disease.

Research Products

• [Journal Article] Clinical features of human T lymphotropic virus type-1 associated uveitis in Hokkaido, Japan (2013)
  • Author(s): Kase S, Namba K, Kitaichi N, Iwata D, Ohno S, Ishida S
  • Journal Title: Jpn J Ophthalmo Volume: Vol.57 Issue: 4 Pages: 379-384
  • DOI: 10.1007/s10384-013-0244-x
  • NAID: 10031189427
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease (2013)
  • Author(s): Meguro A, Mizuki N(他18名)
  • Journal Title: Ann Rheum Dis Volume: 72(9) Issue: 9 Pages: 1510-1516
  • DOI: 10.1136/annrheumdis-2011-200288
  • Peer Reviewed
• [Journal Article] Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice. (2013)
  • Author(s): Lennikov A, Kitaichi N, Kase S, Noda K, Horie Y, Nakai A, Ohno S, Ishida S
  • Journal Title: Int J Mol Sci Volume: 14 Issue: 1 Pages: 2175-2189
  • DOI: 10.3390/ijms14012175
  • NAID: 120005228266
  • Peer Reviewed
• [Journal Article] Trabecular meshwork depigmentation in Vogt-Koyanagi-Harada disease. (2013)
  • Author(s): Mizuuchi K, Kitaichi N, Namba K, Horie Y, Ishida S, Ohno S
  • Journal Title: Jpn J Ophthalmol Volume: 57 Issue: 3 Pages: 245-251
  • DOI: 10.1007/s10384-012-0229-1
  • NAID: 10031176278
  • Peer Reviewed
• [Journal Article] Two cases of subfoveal choroidal neovascularization with tubulointerstitial nephritis and uveitis (TINU) syndrome. (2013)
  • Author(s): Takemoto Y, Namba K, Mizuuchi K, Ohno S, Ishida S.
  • Journal Title: Eur J Ophthalmol Volume: 23 Issue: 2 Pages: 255-257
  • DOI: 10.5301/ejo.5000240
  • Peer Reviewed
• [Journal Article] Identification of contamination in the American Type Culture Collection stock of human adenovirus type 8 by whole genome sequencing. (2013)
  • Author(s): Yamane S, Lee A, Hanaoka N, Gonzalez G, Kaneko H, Ishida S, Kitaichi N, Ohno S, Koyanagi K, Aoki K, Fujimoto T, Yawata N, Watanabe H.
  • Journal Title: J Virol Volume: 87 Issue: 2 Pages: 1285-1286
  • DOI: 10.1128/jvi.02875-12
  • Peer Reviewed
• [Journal Article] Reduction of intraocular pressure using a modified 360-degree suture trabeculotomy technique in primary and secondary open-angle glaucoma: A pilot study (2012)
  • Author(s): Chin S, Nitta T, Shinmei Y, Aoyagi M, Nitta A, Ohno S, Ishida S, Yoshida K.
  • Journal Title: J Glaucoma Volume: 21 Issue: 6 Pages: 401-407
  • DOI: 10.1097/ijg.0b013e318218240c
  • Peer Reviewed
• [Journal Article] Replication of a microsatellite genome-wide association study of Behcet's disease in a Korean population (2012)
  • Author(s): Horie Y, et al
  • Journal Title: Rheumatology Volume: (印刷中) Issue: 6 Pages: 983-6
  • DOI: 10.1093/rheumatology/ker444
  • Peer Reviewed
• [Journal Article] Intravitreal injection of bevacizumab in a case of occlusive retinal vasculitis accompanied with syphilitic intraocular inflammation. (2012)
  • Author(s): Ishijima K, Namba K, Ohno S, Mochizuki K, Ishida S.
  • Journal Title: Case Report Ophthalmol. Volume: 3 Issue: 3 Pages: 434-437
  • DOI: 10.1159/000346046
  • Peer Reviewed
• [Journal Article] Correlation between elevation of serum antinuclear antibody titre and decreased therapeutic efficacy in the treatment of Behçet’s disease with infliximab. (2012)
  • Author(s): Iwata D, Namba K, Mizuuchi K, Kitaichi N, Kase S, Takemoto Y, Ohno S, Ishida S.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 250 Issue: 7 Pages: 1081-1087
  • DOI: 10.1007/s00417-011-1908-1
  • Peer Reviewed
• [Journal Article] Chickenpox chorioretinitis with retinal exudates and periphlebitis. (2012)
  • Author(s): Kitamei H, Namba K, Kitaichi N, Wakayama A, Ohno S, Ishida S.
  • Journal Title: Case Report Ophthalmol. Volume: 3 Issue: 2 Pages: 180-184
  • DOI: 10.1159/000339128
  • Peer Reviewed
• [Journal Article] Amelioration of ultraviolet-induced photokeratitis in mice treated with astaxanthin eye drops (2012)
  • Author(s): Lennikov A, Kitaichi N, Fukase R, Murata M, Noda K, Ando R, Ohguchi T, Kawakita T, Ohno S, Ishida S
  • Journal Title: Mol Vis Volume: Vol.18 Pages: 455-464
  • NAID: 120005372293
  • Peer Reviewed
• [Journal Article] Amelioration of endotoxin-induced uveitis treated with an IκB kinaseβinhibitor in rats (2012)
  • Author(s): Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Fukuhara J, Kinoshita S, Namba K, Mizutani M, Fujikawa T, Itai A, Ohno S, Ishida S
  • Journal Title: Mol Vis Volume: Vol.18 Pages: 2586-2597
  • Peer Reviewed
• [Journal Article] Multicenter study of infliximab for refractory uveoretinitis in Behcet disease (2012)
  • Author(s): Okada AA, Goto H, Ohno S, Mochizuki M, Kitaichi N, Namba K, Keino H, Watanabe T, Ishibashi T, Ito T, Sonoda K, Nakai K, Ohguro N, Sugita S, Kezuka T, Kaburaki T, Takamoto M, Mizuki N
  • Journal Title: Arch Ophthalmol Volume: Vol.130 Pages: 592-598
  • Peer Reviewed
• [Journal Article] Astaxanthin increases choroidal blood flow velocity. (2012)
  • Author(s): Saito M, Yoshida K, Saito W, Fujiya A, Ohgami K, Kitaichi N, Tsukahara H, Ishida S, Ohno S
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. Volume: 250 Issue: 2 Pages: 239-245
  • DOI: 10.1007/s00417-011-1843-1
  • Peer Reviewed
• [Journal Article] Lack of association between IL10 polymorphisms and sarcoidosis in Japanese patients (2012)
  • Author(s): Sakuyama K, Meguro A, Ota M, Ishihara M, Uemoto R, Ito H, Okada E, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Yuasa T, Ohno S, Inoko H, Mizuki N
  • Journal Title: Mol Vis Volume: Vol. 18 Pages: 512-518
  • Peer Reviewed
• [Journal Article] Genetic characterization and susceptibility for sarcoidosis in Japanese patients: risk factors of BTNL2 gene polymorphisms and HLA class II alleles (2012)
  • Author(s): Ota M, Meguro A, Kawagoe T, Mizuki N
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 53 Issue: 11 Pages: 7109-15
  • DOI: 10.1167/iovs.12-10491
  • Peer Reviewed
• [Journal Article] Amelioration of ultraviolet-induced photokeratitis in mice treated with astaxanthin eye drops. (2012)
  • Author(s): Lennikov A, Kitaichi N, Fukase R, Murata M, Noda K, Ando R, Ohguchi T, Kawakita T, Ohno S, Ishida S.
  • Journal Title: Mol Vis. Volume: 18 Pages: 455-464
  • NAID: 120005372293
  • Peer Reviewed
• [Journal Article] Amelioration of endotoxin-induced uveitis treated with an IκB kinase β inhibitor in rats. (2012)
  • Author(s): Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Fukuhara J, Kinoshita S, Namba K, Mizutani M, Fujikawa T, Itai A, Ohno S, Ishida S.
  • Journal Title: Mol Vis. Volume: 18 Pages: 2586-2597
  • NAID: 120005372294
  • Peer Reviewed
• [Journal Article] Multicenter study of infliximab for refractory uveoretinitis in Behcet disease. (2012)
  • Author(s): Okada AA, Goto H, Ohno S, Mochizuki M, Kitaichi N, Namba K, Keino H, Watanabe T, Ishibashi T, Ito T, Sonoda K, Nakai K, Ohguro N, Sugita S, Kezuka T, Kaburaki T, Takamoto M, Mizuki N.
  • Journal Title: Arch Ophthalmol. Volume: 130 Pages: 592-598
  • Peer Reviewed
• [Journal Article] Lack of association between IL10 polymorphisms and sarcoidosis in Japanese patients. (2012)
  • Author(s): Sakuyama K, Meguro A, Ota M, Ishihara M, Uemoto R, Ito H, Okada E, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Yuasa T, Ohno S, Inoko H, Mizuki N.
  • Journal Title: Mol Vis. Volume: 18 Pages: 512-518
  • Peer Reviewed
• [Journal Article] 白金-金コロイド標識抗体を用いたアデノウイルス迅速診断検査キットの評価 (2011)
  • Author(s): 北市伸義、明尾潔、熊埜御堂隆、三島宣彦、三宅瑞絵、大塚宏之、高橋弘毅、溝口晋弘、東真千子、日隈陸太郎、安里良隆、青木功喜、石田晋、大野重昭
  • Journal Title: 医学のあゆみ Volume: 237巻 Pages: 214-215
  • Peer Reviewed
• [Journal Article] Toward an integrated human adenovirus designation system that utilizes molecular and serological data and serves both clinical and fundamental virology (2011)
  • Author(s): Aoki K, Benko M, Davison JA, Echavarria M, Erdman D D, Kitaichi N, Ohno S, 他24名
  • Journal Title: J Viol Volume: Vol.85 Issue: 11 Pages: 5703-5704
  • DOI: 10.1128/jvi.00491-11
  • Peer Reviewed
• [Journal Article] Clinical features of adenoviral conjunctivitis at the early stage of infection (2011)
  • Author(s): Aoki K, Kaneko H, Kitaichi N, Ohguchi T, Tagawa Y, Ohno S
  • Journal Title: Jpn J Ophthalmol Volume: Vol. 55 Issue: 1 Pages: 11-15
  • DOI: 10.1007/s10384-010-0894-x
  • NAID: 10029020444
  • Peer Reviewed
• [Journal Article] Evaluation of NLRP1 gene polymorphisms in Vogt-Koyanagi-Harada disease (2011)
  • Author(s): Horie Y, Saito W, Kitaichi N, Miura T, Ishida S, Ohno S
  • Journal Title: Jpn J Ophthalmol Volume: 55 Issue: 1 Pages: 57-61
  • DOI: 10.1007/s10384-010-0887-9
  • NAID: 10029020610
  • Peer Reviewed
• [Journal Article] Investigation of Association between TLR9 Gene Polymorphisms and VKH in Japanese Patients (2011)
  • Author(s): Ito Ryuta; Ota Masao; Meguro Akira, et al
  • Journal Title: OCULAR IMMUNOLOGY AND INFLAMMATION Volume: 19:3 Issue: 3 Pages: 202-205
  • DOI: 10.3109/09273948.2011.553981
  • Peer Reviewed
• [Journal Article] Genome variability of human adenovirus type 8 causing epidemic keratoconjunctivitis during 1986-2003 in Japan (2011)
  • Author(s): Jin XH, Aoki K, Kitaichi N, Ariga T, Ishida S, Ohno S
  • Journal Title: Mol Vis Volume: Vol.17 Pages: 3121-3127
  • Peer Reviewed
• [Journal Article] Detection of human adenovirus hexon antigen using carbon nanotube sensors (2011)
  • Author(s): Jin XH, Ishii A, Aoki K, Ishida S, Mukasa K, Ohno S
  • Journal Title: J Virol Methods Volume: Vol.171 Issue: 2 Pages: 405-407
  • DOI: 10.1016/j.jviromet.2010.12.004
  • Peer Reviewed
• [Journal Article] Recombination analysis of intermediate human adenovirus type 53 in Japan by complete genome sequence (2011)
  • Author(s): Hisatoshi Kaneko, Koki Aoki, Susumu Ishida, Shigeaki Ohno, Nobuyoshi Kitaichi, Hiroaki Ishiko, Tsuguto Fujimoto, Yoshifumi Ikeda, Masako Nakamura, Gabriel Gonzalez, Kanako O.Koyanagi, Hidemi Watanabe, Tatsuo Suzutani
  • Journal Title: Journal of General Virology Volume: 92 Issue: 6 Pages: 1251-1259
  • DOI: 10.1099/vir.0.030361-0
  • Peer Reviewed
• [Journal Article] Epidemiological and virological features of epidemic keratoconjunctivitis due to new human adenovirus type 54 in Japan (2011)
  • Author(s): Kaneko H, Suzutani T, Aoki K, Kitaichi N, Ishida S, Ishiko H, Ohashi T, Okamoto S, Nakagawa H, Hinokuma R, Asato Y, Oniki S, Hashimoto T, Iida T, Ohno S.
  • Journal Title: Br J Ophthalmol Volume: 95 Issue: 1 Pages: 32-36
  • DOI: 10.1136/bjo.2009.178772
  • Peer Reviewed
• [Journal Article] Diffuse infiltrating retinoblastoma invading subarachnoid space (2011)
  • Author(s): Kase S, Yoshida K, Suzuki S, Ohshima KI, Ohno S, Ishida S
  • Journal Title: Clin Ophthalmol Volume: Vol. 5 Pages: 861-863
  • DOI: 10.2147/opth.s20913
  • NAID: 120005372299
  • Peer Reviewed
• [Journal Article] Association analysis of Toll-like receptor 7 gene polymorphisms and Behcet's disease in Japanese (2011)
  • Author(s): Sada T, et al
  • Journal Title: Human Immunology Volume: 72 Issue: 3 Pages: 269-272
  • DOI: 10.1016/j.humimm.2010.12.007
  • Peer Reviewed
• [Journal Article] Toll-like receptor2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population (2011)
  • Author(s): Sato M, Kawagoe T, Meguro A, Ota M, Katsuyama Y, Ishihara M, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Ohno S, Inoko H, Mizuki N
  • Journal Title: Mol Vis Volume: Vol. 17 Pages: 731-736
  • Peer Reviewed
• [Journal Article] Japanese Guideline for Allergic Conjunctival Diseases (2011)
  • Author(s): Takamura E, Uchio E, Ebihara N, Ohno S, Ohashi Y, Okamoto S, Kumagai N, Satake Y, Shoji J, Nakagawa Y, Namba K, Fukagawa K, Fukushima A, Fujishima H
  • Journal Title: Allergology International Volume: 60 Issue: 2 Pages: 191-203
  • DOI: 10.2332/allergolint.11-RAI-0335
  • NAID: 130004477096
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] 白金-金コロイド標識抗体を用いたアデノウイルス迅速診断検査キットの評価 (2011)
  • Author(s): 北市伸義、明尾 潔、熊埜御堂隆、三島宣彦、三宅瑞絵、大塚宏之、高橋弘毅、溝口晋弘、東真千子、日隈陸太郎、安里良隆、青木功喜、石田 晋、大野重昭
  • Journal Title: 医学のあゆみ Volume: 237 Pages: 210-214
  • Peer Reviewed
• [Journal Article] Clinical features of adenoviral conjunctivitis at the early stage of infection. (2011)
  • Author(s): Aoki K, Kaneko H, Kitaichi N, Ohguchi T, Tagawa Y, Ohno S
  • Journal Title: Jpn J Ophthalmol Volume: 55 Pages: 11-15
  • NAID: 10029020444
  • Peer Reviewed
• [Journal Article] Genome variability of human adenovirus type 8 causing epidemic keratoconjunctivitis during 1986-2003 in Japan. (2011)
  • Author(s): Jin XH, Aoki K, Kitaichi N, Ariga T, Ishida S, Ohno S
  • Journal Title: Mol Vis Volume: 17 Pages: 3121-3127
  • Peer Reviewed
• [Journal Article] Toll-like receptor2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population. (2011)
  • Author(s): Sato M, Kawagoe T, Meguro A, Ota M, Katsuyama Y, Ishihara M, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Ohno S, Inoko H, Mizuki N
  • Journal Title: Mol Vis Volume: 17 Pages: 731-736
  • Peer Reviewed
• [Presentation] Clinical features of Vogt-Koyanagi-Harada's disease (2013)
  • Author(s): Ohno S, Namba K, Kitaichi N
  • Organizer: 7th Korean Uveitis Conference
  • Place of Presentation: Seoul, Korea, Seoul National University
  • Year and Date: 2013-11-23
• [Presentation] Disease mechanisms and tretment of Behcet's disease (2013)
  • Author(s): Ohno S
  • Organizer: 14th Behcet's Disease
  • Place of Presentation: Seoul, Korea, Seoul National University
  • Year and Date: 2013-11-22
• [Presentation] Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice. (2013)
  • Author(s): Kitaichi N, Lennikov A, Kase S, Noda K, Horie Y, Ohno S, Ishida S.
  • Organizer: ARVO (Association for Research in Vision and Ophthalmology) Annual Meeting
  • Place of Presentation: Seattle, USA, Washington State Convention Center
• [Presentation] A Case of tuberculous endophthalmitis (2013)
  • Author(s): Hase K, Namba K, Saito W, Takemoto Y, Mizuuchi K, Ohno S, Ishida S.
  • Organizer: International Workshop on Granulomatous Uveitis and Ocular Behcet's disease and Asia-Pacific Intraocular Inflammation Study Group
  • Place of Presentation: Kaohsiung, Taiwan, Han-Hsien International Hotel
• [Presentation] Outcome of a modified 360-degree trabeculotomy for uveitic glaucoma with peripheral anterior synechiae (2013)
  • Author(s): Shinmei Y, Chin S, Yamamoto M, Nitta T, Namba K, Ohno S, Ishida S.
  • Organizer: International Workshop on Granulomatous Uveitis and Ocular Behcet's disease and Asia-Pacific Intraocular Inflammation Study Group
  • Place of Presentation: Kaohsiung, Taiwan, Han-Hsien International Hotel
• [Presentation] 脈絡膜新生血管を合併しベバシズマブ硝子体注射を要した小児原田病の1例 (2013)
  • Author(s): 田川義晃、南場研一、齋藤 航、水内一臣、北市伸義、大野重昭、石田 晋
  • Organizer: フォーサム2013大阪
  • Place of Presentation: 大阪国際会議場（大阪市）
• [Presentation] 周辺虹彩前癒着を伴うぶどう膜炎に続発した緑内障に対するsuture-trabeculotomyの成績 (2013)
  • Author(s): 大口剛司、新明康弘、新田卓也、山本麻梨亜、南場研一、大野重昭、陳 進輝、石田 晋
  • Organizer: 第117回 日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
• [Presentation] ぶどう膜炎における網羅的糖差解析 (2013)
  • Author(s): 南場研一、北市伸義、安藤 亮、竹本裕子、水内一臣、堀江幸弘、大野重昭、天野麻穂、西村紳一郎、石田 晋
  • Organizer: 第117回 日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
• [Presentation] ベーチェット病眼炎症発作とインフリキシマブトラフ値・サイトカイン血中濃度との相関 (2013)
  • Author(s): 水内一臣、竹本裕子、南場研一、宇野友絵、大野重昭、石田 晋
  • Organizer: 第117回 日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
• [Presentation] Clinical features of Vogt-Koyanagi-Harada’s disease (2013)
  • Author(s): Ohno S, Namba K, Kitaichi N.
  • Organizer: 7th Korean Uveitis Conference
  • Place of Presentation: Seoul, Korea, Seoul National University
  • Invited
• [Presentation] Disease mechanisms and tretment of Behcet’s disease (2013)
  • Author(s): Ohno S
  • Organizer: 14th Behcet’s Disease
  • Place of Presentation: Seoul, Korea, Seoul National University
  • Invited
• [Presentation] Management dilemmas in uveitis (2012)
  • Author(s): Ohno S, Chin S
  • Organizer: Second Biennial National Conference
  • Place of Presentation: Bangladesh Uvea Society, Dhaka, Bang ladesh
  • Year and Date: 2012-12-15
• [Presentation] Presentation perspectives in Vogt-Koyanagi-Harada disease (2012)
  • Author(s): Ohno S
  • Organizer: Second Biennial National Conference
  • Place of Presentation: Bangladesh Uvea Society, Dhaka, Bangladesh
  • Year and Date: 2012-12-15
• [Presentation] Corticosteroid therapy in uveitis (2012)
  • Author(s): Ohno S
  • Organizer: Ophthalmology Seminar
  • Place of Presentation: Thimpu National Referral Hospital, Thimpu, Bhutan
  • Year and Date: 2012-12-12
• [Presentation] Management of second ry glaucoma in uveitis (2012)
  • Author(s): Ohno S, Chin S
  • Organizer: Ophthalmology Seminar
  • Place of Presentation: Thimpu National Referral Hospital : Thimpu, Bhutan
  • Year and Date: 2012-12-12
• [Presentation] From autoimmunity to autoinf lammation in the immunopathogenesis of Behcet's disease (2012)
  • Author(s): Ohno S
  • Organizer: 2012 Seoul National University-Hokkaido University Joint Symposium in Ophthalmology
  • Place of Presentation: Sapporo(Hokkaido University), Japan
  • Year and Date: 2012-10-19
• [Presentation] Epidemiology and genetics of Behcet's disease (2012)
  • Author(s): Ohno S
  • Organizer: Bechet's Disease Symposium; How to differentiate Behcet's disease from other types of uveitis
  • Place of Presentation: Sani(Sani Beach Resort), Greece
  • Year and Date: 2012-10-19
• [Presentation] Silk route disease : epidemio logy and genetics (2012)
  • Author(s): Ohno S
  • Organizer: International meeting of collaborative studies on Behcet's disease and other uveitis entities
  • Place of Presentation: Rome(ローマ大学), Italy
  • Year and Date: 2012-10-16
• [Presentation] Anti-TNFαtherapy for intractable uveoreti nitis in Behcet's disease (2012)
  • Author(s): Ohno S
  • Organizer: 15th International Conference on Behcet's Disease
  • Place of Presentation: Yokohama(パシフィコ横浜), Japan
  • Year and Date: 2012-07-14
• [Presentation] Diagnosis and treatment of a llergic conjuctivitis (2012)
  • Author(s): Ohno S
  • Organizer: 16th Afro Asian Congress of Ophthal mology
  • Place of Presentation: Istanabul(HARBIYE MILITARY MUSEUM), Turkey
  • Year and Date: 2012-06-15
• [Presentation] Ocular lesions in Behcet's disease (2012)
  • Author(s): Ohno S
  • Organizer: 16th Afro Asian Congress of Ophthalmology
  • Place of Presentation: Istanabul(HARBIYE MILITARY MUSEUM), Turkey
  • Year and Date: 2012-06-13
• [Presentation] Epidemiology of allergic con junctival diseases in Japan (2012)
  • Author(s): Ohno S
  • Organizer: 1st Conference on the Tear Film and Ocular Surface in Asia
  • Place of Presentation: Kamakura(Kenchoji), Japan
  • Year and Date: 2012-04-04
• [Presentation] Amelioration of endotoxin-induced uveitis treated with an IkappaB kinase beta inhibitor (2012)
  • Author(s): Kitaichi N, Lennikov A, Namba K, Noda K, Kanda A, Ando R, Dong Z, Fukuhara J, Kinoshita S, Ohno S, Ishida S.
  • Organizer: 8th International Symposium on Uveitis
  • Place of Presentation: Sani(Sani Beach Resort), Greece
• [Presentation] Amelioration of experimental autoimmune uveoretinitis by inhibiton of Glyceraldehide-derived AGEs formation (2012)
  • Author(s): Kitaichi N, Dong Z, Iwata D, Takeuchi M, Namba K, Noda K, Kanda A, Iwabuchi K, Yamagishi S, Ohno S, Ishida S.
  • Organizer: 15th International Conference on Behcet's Disease
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜、 Yokohama, Japan
• [Presentation] Amelioration of endotoxin-induced uveitis treated with IMD-0354, an IkappaB inhibitor (2012)
  • Author(s): Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Namba K, Ohno S, Ishida S.
  • Organizer: 15th International Conference on Behcet's Disease
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜、 Yokohama, Japan
• [Presentation] Correlation between development of antinuclear antibody titre and decreased therapeutic efficacy in the treatment of Behçet’s disease with infliximab (2012)
  • Author(s): Namba K, Iwata D, Mizuuchi K, Kitaichi N, Kase S, Takemoto Y, Ohno S, Ishida S.
  • Organizer: 15th International Conference on Behcet's Disease
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜、 Yokohama, Japan
• [Presentation] Effects of Infliximab Therapy in Behcet's disease (2012)
  • Author(s): Takemoto Y, Namba K, Kitaichi N, Mizuuchi K, Ohno S,
  • Organizer: 15th International Conference on Behcet's Disease
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜、 Yokohama, Japan
• [Presentation] Genome variability of human adenovirus type 8 causing epidemic keratoconjunctivitis in Japan (2012)
  • Author(s): Kitaichi N, Aoki K, Jin XH, Kaneko H, Gonzalez G, Yawata N, Koyanagi KO, Watanabe H, Ishida S, Ohno S.
  • Organizer: 10th International Adenovirus Meeting
  • Place of Presentation: Umea University, Sweden
• [Presentation] Epidemic keratoconjunctivitis (EKC) caused by human adenovirus in Hungary (2012)
  • Author(s): Pantó L, Gonzalez G, Koyanagi KO, Pankovics P, Reuter G, Kitaichi N, Ishida S, Ohno S, Aoki K, Watanabe H.
  • Organizer: 10th International Adenovirus Meeting
  • Place of Presentation: Umea University, Sweden
• [Presentation] Serum and salivary levels of bioactive antimicrobial peptide LL-37 in Behçet's disease and other ocular inflammatory diseases (2012)
  • Author(s): Isogai E, Kuroda K, Seki S, Kitaichi N, Namba K, Ohno S, Yoneyama H, Isogi H.
  • Organizer: 3rd International Symposium on Antimicrobial Peptides
  • Place of Presentation: Lille(Villeneuve d'Ascq), France
• [Presentation] Amelioration of experimental autoimmune uveoretinitis by inhibiton of toxic AGEs formation (2012)
  • Author(s): Dong Z, Kitaichi N, Iwata D, Ando R, Fukuhara J, Lennikov A, Kanda A, Noda K, Ohno S, Ishida S.
  • Organizer: ARVO (Association for Research in Vision and Ophthalmology) Annual Meeting
  • Place of Presentation: Greater Fort Lauderdale／Broward County convention Center, USA
• [Presentation] Amelioration of endotoxin-induced uveitis treated with an IKB kinase inhibitor, IMD-0354 in rats (2012)
  • Author(s): Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Namba K, Ohno S, Ishida S.
  • Organizer: ARVO (Association for Research in Vision and Ophthalmology) Annual Meeting
  • Place of Presentation: Greater Fort Lauderdale／Broward County convention Center, USA
• [Presentation] Management dilemmas in uveitis. (2012)
  • Author(s): Ohno S, Chin S.
  • Organizer: Second Biennial National Conference,
  • Place of Presentation: Bangladesh Uvea Society：Dhaka, Bangladesh
  • Invited
• [Presentation] Presentation perspectives in Vogt-Koyanagi-Harada disease. (2012)
  • Author(s): Ohno S.
  • Organizer: Second Biennial National Conference,
  • Place of Presentation: Bangladesh Uvea Society：Dhaka, Bangladesh
  • Invited
• [Presentation] Corticosteroid therapy in uveitis. (2012)
  • Author(s): Ohno S.
  • Organizer: Ophthalmology Seminar
  • Place of Presentation: Thimpu National Referral Hospital: Thimpu, Bhutan
  • Invited
• [Presentation] Management of secondry glaucoma in uveitis. (2012)
  • Author(s): Ohno S, Chin S.
  • Organizer: Ophthalmology Seminar
  • Place of Presentation: Thimpu National Referral Hospital: Thimpu, Bhutan
  • Invited
• [Presentation] From autoimmunity to autoinflammation in the immunopathogenesis of Behcet's disease. (2012)
  • Author(s): Ohno S.
  • Organizer: 2012 Seoul National University-Hokkaido University Joint Symposium in Ophthalmology
  • Place of Presentation: Sapporo(Hokkaido University), Japan
  • Invited
• [Presentation] Epidemiology and genetics of Behcet's disease. (2012)
  • Author(s): Ohno S.
  • Organizer: Bechet’s Disease Symposium; How to differentiate Behcet's disease from other types of uveitis.
  • Place of Presentation: Sani(Sani Beach Resort), Greece
  • Invited
• [Presentation] Silk route disease: epidemiology and genetics. (2012)
  • Author(s): Ohno S.
  • Organizer: International meeting of collaborative studies on Behcet’s disease and other uveitis entities
  • Place of Presentation: Rome（ローマ大学）, Italy
  • Invited
• [Presentation] Anti-TNFα therapy for intractable uveoretinitis in Behcet's disease. (2012)
  • Author(s): Ohno S.
  • Organizer: 15th International Conference on Behcet's Disease
  • Place of Presentation: Yokohama（ﾊﾟｼﾌｨｺ横浜）, Japan
  • Invited
• [Presentation] Diagnosis and treatment of allergic conjuctivitis. (2012)
  • Author(s): Ohno S.
  • Organizer: 16th Afro Asian Congress of Ophthalmology
  • Place of Presentation: Istanabul（HARBIYE MILITARY MUSEUM）, Turkey
  • Invited
• [Presentation] Ocular lesions in Behcet’s disease. (2012)
  • Author(s): Ohno S.
  • Organizer: 16th Afro Asian Congress of Ophthalmology
  • Place of Presentation: Istanabul（HARBIYE MILITARY MUSEUM）, Turkey
  • Invited
• [Presentation] Epidemiology of allergic conjunctival diseases in Japan. (2012)
  • Author(s): Ohno S.
  • Organizer: 1st Conference on the Tear Film and Ocular Surface in Asia:
  • Place of Presentation: Kamakura（Kenchoji), Japan
  • Invited
• [Presentation] Treatment of Behcet's disease with infliximab.3rd Japan-Korea Symposium on Behcet's Disease (2011)
  • Author(s): Ohno S, Namba K, Kitaichi N, Mizuki N
  • Organizer: Behcet's Disease Study Group, Ministry of Health. Labour and Welfare, Japan
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2011-12-16
• [Presentation] Infliximab therapy of Behcet's disease (2011)
  • Author(s): Ohno S, Namba K, Kitaichi N, Mizuki N
  • Organizer: 3rd International Uveitis Symposium
  • Place of Presentation: 重慶カールトンホテル(中国)
  • Year and Date: 2011-12-02
• [Presentation] Molecular genetics of uveitis (2011)
  • Author(s): Ohno S, Mizuki N
  • Organizer: International Symposium on Recent Trends in Uveitis
  • Place of Presentation: LV Prasad Eye Institue (India)
  • Year and Date: 2011-11-18
• [Presentation] Corticosteroid therapy of uveitis and intraocular inflammation (2011)
  • Author(s): Ohno S, Namba K
  • Organizer: International Symposium on Recent Trends in Uveitis
  • Place of Presentation: LV Prasad Eye Institue (India)
  • Year and Date: 2011-11-18
• [Presentation] Epidemiology of Behcet's disease. Session; Behcet's Disease : An Update and Future Prospects (2011)
  • Author(s): Ohno S, Kitaichi N, Meguro A, Mizuki N, Isogai E
  • Organizer: 11th International Ocular Inflammation Society (IOIS) Congress and International Assembly of Ocular Inflammation Societies
  • Place of Presentation: Hotel Taj Exotica (India)
  • Year and Date: 2011-11-15
• [Presentation] Update of anti-TNF alpha therapy in Behcet's disease (2011)
  • Author(s): Ohno S, Namba K, Iwata D, Kitaichi N, Mizuki N
  • Organizer: Italian Society of Uveitis and Inflammatory Ocular Diseases, (SIUMIO) / 11th International Ocular Inflammation Society (IOIS) Congress and International Assembly of Ocular Inflammation Societies
  • Place of Presentation: Hotel Taj Exotica (India)
  • Year and Date: 2011-11-15
• [Presentation] Introduction, Conclusions and Future, Workshop on Epidemiology and Diagnosis of Behcet's Disease (2011)
  • Author(s): Ohno S
  • Organizer: First Workshop of (IOBDSG) / 11th IOIS Congress and International Assembly of Ocular Inflammation Societies
  • Place of Presentation: Hotel Taj Exotica (India)
  • Year and Date: 2011-11-14
• [Presentation] Panel Discussion with Chee SP, Goto H, Rao NA, Future studies and conclusions (2011)
  • Author(s): Ohno S, Panel Discussion with Chee SP, Goto H, Rao NA
  • Organizer: The 7th International Workshop of Vogt-Koyanagi-Harada Disease and Sympathetic Ophthalmia / 11th IOIS Congress and International Assembly of Ocular Inflammation Societies
  • Place of Presentation: Hotel Taj Exotica (India)
  • Year and Date: 2011-11-14
• [Presentation] Trabecular depigmentation in convalescent stage of VKH disease (2011)
  • Author(s): Ohno S, Mizuuchi K, Namba K, Kitaichi N, Horie Y
  • Organizer: The 7th International Workshop of Vogt-Koyanagi-Harada Disease and Sympathetic Ophthalmia / 11th IOIS Congress and International Assembly of Ocular Inflammation Societies
  • Place of Presentation: Hotel Taj Exotica (India)
  • Year and Date: 2011-11-14
• [Presentation] Classification and diagnostic criteria for Behcet's disease (2011)
  • Author(s): Ohno S, Namba K, Kitaichi N
  • Organizer: 11th IOIS Congress and International Assembly of Ocular Inflammation Societies
  • Place of Presentation: Hotel Taj Exotica (India)
  • Year and Date: 2011-11-14
• [Presentation] Managing ocular manifestations of systemic diseases with local therapy : Is it possible? (2011)
  • Author(s): Ohno S, Namba K, Kitaichi N
  • Organizer: 11th IOIS Congress and International Assembly of Ocular Inflammation Societies
  • Place of Presentation: Hotel Taj Exotica (India)
  • Year and Date: 2011-11-13
• [Presentation] Treatment of Behcet’s disease with infliximab. (2011)
  • Author(s): Ohno S, Namba K, Kitaichi N, Mizuki N
  • Organizer: 3rd Japan-Korea Symposium on Behcet’s Disease, Behcet’s Disease Study Group, Ministry of Health. Labour and Welfare, Japan(招待講演)
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] Infliximab therapy of Behcet’s disease. (2011)
  • Author(s): Ohno S, Namba K, Kitaichi N, Mizuki N
  • Organizer: 3rd International Uveitis Symposium.(招待講演)
  • Place of Presentation: 重慶カールトンホテル（中国）
• [Presentation] Epidemiology of Behcet’s disease. Session; Behcet’s Disease : An Update and Future Prospects. (2011)
  • Author(s): Ohno S, Kitaichi N, Meguro A, Mizuki N, Isogai E
  • Organizer: 11th International Ocular Inflammation Society (IOIS) Congress and International Assembly of Ocular Inflammation Societies(招待講演)
  • Place of Presentation: Hotel Taj Exotica (India)
• [Presentation] Update of anti-TNF alpha therapy in Behcet’s disease. (2011)
  • Author(s): Ohno S, Namba K, Iwata D, Kitaichi N, Mizuki N
  • Organizer: Italian Society of Uveitis and Inflammatory Ocular Diseases (SIUMIO) / 11th International Ocular Inflammation Society (IOIS) Congress and International Assembly of Ocular Inflammation Societies(招待講演)
  • Place of Presentation: Hotel Taj Exotica (India)
• [Presentation] Introduction, Conclusions and Future. Workshop on Epidemiology and Diagnosis of Behcet's Disease. (2011)
  • Author(s): Ohno S
  • Organizer: First Workshop of (IOBDSG) / 11th IOIS Congress and International Assembly of Ocular Inflammation Societies(招待講演)
  • Place of Presentation: Hotel Taj Exotica (India)
• [Presentation] Panel Discussion with Chee SP, Goto H, Rao NA, Future studies and conclusions. (2011)
  • Author(s): Ohno S
  • Organizer: The 7th International Workshop of Vogt-Koyanagi-Harada Disease and Sympathetic Ophthalmia / 11th IOIS Congress and International Assembly of Ocular Inflammation Societies(招待講演)
  • Place of Presentation: Hotel Taj Exotica (India)
• [Presentation] Trabecular depigmentation in convalescent stage of VKH disease. (2011)
  • Author(s): Ohno S, Mizuuchi K, Namba K, Kitaichi N, Horie Y
  • Organizer: The 7th International Workshop of Vogt-Koyanagi-Harada Disease and Sympathetic Ophthalmia / 11th IOIS Congress and International Assembly of Ocular Inflammation Societies(招待講演)
  • Place of Presentation: Hotel Taj Exotica (India)
• [Presentation] Classification and diagnostic criteria for Behcet’s disease. (2011)
  • Author(s): Ohno S, Namba K, Kitaichi N
  • Organizer: 11th IOIS Congress and International Assembly of Ocular Inflammation Societies(招待講演)
  • Place of Presentation: Hotel Taj Exotica (India)
• [Presentation] Managing ocular manifestations of systemic diseases with local therapy: Is it possible? (2011)
  • Author(s): Ohno S, Namba K, Kitaichi N
  • Organizer: 11th IOIS Congress and International Assembly of Ocular Inflammation Societies(招待講演)
  • Place of Presentation: Hotel Taj Exotica (India)
• [Presentation] Molecular genetics of uveitis. (2011)
  • Author(s): Ohno S, Mizuki N
  • Organizer: International Symposium on Recent Trends in Uveitis(招待講演)
  • Place of Presentation: LV Prasad Eye Institue (India)
• [Presentation] Corticosteroid therapy of uveitis and intraocular inflammation. (2011)
  • Author(s): Ohno S, Namba K
  • Organizer: International Symposium on Recent Trends in Uveitis(招待講演)
  • Place of Presentation: LV Prasad Eye Institue (India)
• [Book] 小児感染症学 (2011)
  • Author(s): 北市伸義, 大野重昭
  • Total Pages: 396
  • Publisher: 診断と治療社
• [Book] 治療薬ハンドブック2011 (2011)
  • Author(s): 北市伸義, 大野重昭
  • Total Pages: 1427
  • Publisher: じほう
• [Book] 小児感染症学 (2011)
  • Author(s): 北市伸義, 大野重昭.
  • Total Pages: 396
  • Publisher: 診断と治療社