| Project/Area Number |
23592602
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Susumu 北海道大学, 大学院研究科, 教授 (10245558)
NAMBA Kenichi 北海道大学, 大学病院, 講師 (70333599)
KITAICHI Nobuyoshi 北海道大学, 医学研究科, 客員准教授 (40431366)
MEGURO Akira 横浜市立大学, 医学研究科, 特任助教 (60508802)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUKI Nobuhisa 横浜市立大学, 医学研究科, 教授 (90336579)
SAWASAKI Tatsuya 愛媛大学, 無細胞生命科学工学研究 センター, 准教授 (50314969)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | ぶどう膜炎 / ベーチェット病 / 原田病 / 自己抗体 / 内因性ぶどう膜炎 / 難治性内因性ぶどう膜炎 / 網羅的解析 / バイオインフォマティクス解析 / バイオマーカー |
|---|
| Research Abstract |
In this study, serum autoantigens were examined comprhensively in the patients with endogenous uveitis by using our novel detection system.Serum samples were divided into 3 pooled groups.
Among Vogt-Koyanagi-Harada disease patients, 10 kinds of proteins were elevated more than one-and-a-half levels compared with healthy volunteers in sera. Behcet's disease patients also showed that 6 kinds of serum proteins were increased levels by half compared with those of healthy subjects.
We further demonstarted that 3 of these elevated proteins were common to Vogt-Koyanagi-Harada disease and Behcet disease.
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