| Project/Area Number |
23592605
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
MATSUSHITA Kenji 大阪大学, 医学(系)研究科(研究院), 講師 (40437405)
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| Co-Investigator(Kenkyū-buntansha) |
三木 篤也 大阪大学, 助教 (30437404)
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| Co-Investigator(Renkei-kenkyūsha) |
福山 直人 東海大学, 準教授 (50349338)
静間 徹 東海大学, 専任講師 (20307523)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 医用工学 / 放射光微小血管造影法 / 緑内障 / 眼医工学 / 放射光 |
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| Research Abstract |
Recent adavances in optical coherence tomography allow visualization of the optic nerve structure. However, the infrared light source is limited in its ability to analyze the retrobulbar structure because of insufficient penetration; in contrast, X-rays can penetrate deeper. We developed a model for retrobulbar angiography with computed tomography to reveal the retrobulbar structures around the optic nerve head. Four-week-old SD rats were observed alive with CT. Trough the catheter, we had injected a contrast agent, iohexol and an iodine-containing polymer solution. After contrast agent washout, the CT values were recorded at baseline, maximal contrast agent enhancement, washout, and maximal iodine-containing polymer enhancement. We localized the area governed by ICA. The polymer stayed in the eye after the contrast was flushed from the orbit. We developed a model for retrobulbar angiography that makes it easy to adjust the imaging conditions.
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