Role of Oct3/4 in retinal development and dieseases
| Project/Area Number |
23592606
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Okayama University |
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Principal Investigator |
KOSAKA MITSUKO 岡山大学, 医歯(薬)学総合研究科, 助教 (50270476)
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| Research Collaborator |
MIZUNO Nobuhiko 兵庫県立大学, 大学院理学生命研究科, 客員 研究員 (60462735)
OHTUKA Aiji 岡山大学, 大学院医歯薬学総合研究科, 教授 (50168986)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 網膜 / 幹細胞 / Oct3/4 / 転写調節因子 / 再生 / がん / 発生 / 国際情報交換 / 組織幹細胞 |
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| Research Abstract |
We tried to investigate roles of Oct3/4 gene during development of normal retina and retinal diseases including tumors. At the first step, we re-investigated Oct3/4 expression in mouse eye. We isolated a novel Oct3/4 variant from normal mouse retina, which is regulated under translational control. Using human retinoblastoma and other carcinoma cell lines, we tested the expression of Oct3/4 transcripts and identified a variety of novel ones. Our results showed the clear different pattern between mice and human Oct3/4 gene variants expression, providing available relevant information for understanding the function of Oct3/4 in somatic tissue.
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Report
(4 results)
Research Products
(9 results)
