| Project/Area Number |
23592610
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kumamoto University |
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Principal Investigator |
FUKUSHIMA Mikiko 熊本大学, 生命科学研究部(医), 准教授 (10284770)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Yasuhiro 熊本大学, 医学部附属病院, 助教 (70380996)
INOUE Toshihiro 熊本大学, 医学部附属病院, 講師 (00317025)
TAKAHASHI Eri 熊本大学, 大学院生命科学研究部, 助教 (60622602)
GYOUTOKU Yuji 熊本大学, 医学部附属病院, 助教 (10420639)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 再生医学 / 細胞・組織 / 生理活性分子 / 眼科学 / 眼発生・再生医学 / 眼細胞生物学 |
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| Research Abstract |
This study was related to the control mechanism differentiation of retinal tissue stem cells and was analyzed by using a sample eye disease and retinal injury animal model. It was possible to suppress glial differentiation of neural stem cells transplanted as well as the expression of CNTF belonging to the IL-6 superfamily is an inflammatory cytokine by a non-steroidal anti-inflammatory agent administered in the retinal injury animal model. Increased expression inflammatory cytokines, growth factors, of amyloid-related proteins was revealed cataract, glaucoma, and retinal disease in specific in the analysis using a sample eye disease. In retinal pigment epithelial cell culture analysis, the transformation-induced effect on the vitreous humor with retinal detachment, epiretinal membrane disease, involvement of phosphorylation signal smad, of NF-kB has been revealed.
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