A study for protective mechanisms of VGF, a neurosecretory peptide, in retinal injury

• Project/Area Number: 23592612
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Gifu Pharmaceutical University
• Principal Investigator: SHIMAZAWA Masamitsu 岐阜薬科大学, 薬学部, 准教授 (80381721)
• Co-Investigator(Kenkyū-buntansha): HARA Hideaki 岐阜薬科大学, 薬学部, 教授 (20381717)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 眼薬理学 / 緑内障 / 網膜神経節細胞 / 小胞体ストレス

Research Abstract

We performed to clarify the involvement of VGF nerve growth factor inducible (VGF), a neurosecretory peptide, in retinal injury. VGF588-617 (AQEE30), an active VGF peptide, inhibited neuronal cell death induced by endoplasmic reticulum (ER) stress, and it increased phosphorylated Akt, a cell survival factor. These data suggest that VGF may protect neuronal cells by activation of cell survival signals. Furthermore, VGF increased with ER stress in retina of glaucoma model mice.

Research Products

• [Journal Article] Establishment of the ocular hypertension model using the common marmoset (2013)
  • Author(s): Shimazawa, M., Nakamura, S., Miwa, M., Tsuruma, K., Aihara, M., Nakamura, K., Hara, H
  • Journal Title: Exp Eye Res Volume: 111 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Establishment of the ocular hypertension model using the common marmoset (2013)
  • Author(s): Masamitsu Shimazawa, Shinsuke Nakamura, Miki Miwa, Kazuhiro Tsuruma, Makoto Aihara, Katsuki Nakamura, Hideaki Hara
  • Journal Title: Experimental Eye Research Volume: 111C Pages: 1-8
  • DOI: 10.1016/j.exer.2013.03.010
  • Peer Reviewed
• [Journal Article] Induction of amyloid-beta(1-42) in the retina and optic nerve head of chronic ocular hypertensive monkeys (2012)
  • Author(s): Ito, Y., Shimazawa, M., Tsuruma, K., Mayama, C., Ishii, K., Onoe, H., Aihara, M., Araie, M., Hara, H
  • Journal Title: Mol Vis Volume: 18 Pages: 2647-2657
  • Peer Reviewed
• [Journal Article] Involvement of endoplasmic reticulum stress in optic nerve degeneration following N-methyl-D-aspartate- induced retinal damage in mice (2012)
  • Author(s): Shimazawa, M., Miwa, A., Ito, Y., Tsuruma, K., Aihara, M., Hara, H
  • Journal Title: J Neurosci Res Volume: 90 Pages: 1960-1969
  • Peer Reviewed
• [Journal Article] An Alteration in the Lateral Geniculate Nucleus of Experimental Glaucoma Monkeys : In vivo Positron Emission Tomography Imaging of Glial Activation (2012)
  • Author(s): Shimazawa, M., Ito, Y., Inokuchi, Y., Yamanaka, H., Nakanishi, T., Hayashi, T., Ji, B., Higuchi, M., Suhara, T., Imamura, K., Araie, M., Watanabe, Y., Onoe, H., Hara, H.
  • Journal Title: PLoS One Volume: 7
  • Peer Reviewed
• [Journal Article] An alteration in the lateral geniculate nucleus of experimental glaucoma monkeys: In vivo positoron emission tomography imaging of glial activation (2012)
  • Author(s): Shimazawa M., Ito Y., Inokuchi Y., Yamanaka H., Hayashi T., Jin B., Higuchi M., Suhara T., Imamura K., Araie M., Watanabe Y., Onoe H., Hara H
  • Journal Title: PLoS one Volume: 7(1) Issue: 1 Pages: 1-14
  • DOI: 10.1371/journal.pone.0030526
  • Peer Reviewed
• [Journal Article] Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity (2011)
  • Author(s): Yamauchi, M., Tsuruma, K., Imai, S/,Nakanishi, T., Umigai, N., Shimazawa, M., Hara, H.
  • Journal Title: Eur J Pharmacol Volume: 650 Pages: 110-119
• [Presentation] 緑内障の病態解明と神経保護をターゲットとした薬物治療の現状と将来展望 (2012)
  • Author(s): 嶋澤雅光、原英彰
  • Organizer: 第32回日本眼薬理学会
  • Place of Presentation: 大津
  • Invited
• [Presentation] 緑内障の病態解明と神経保護をターゲットとした薬物治療の現状と将来展望 (2012)
  • Author(s): 嶋澤 雅光、原 英彰
  • Organizer: 第32回 日本眼薬理学会
  • Place of Presentation: ピアザ淡海
  • Invited