Visual rehabilitation and biological analysis of cultivated oral mucosal epithelium and reconstructed ocular surface
| Project/Area Number |
23592614
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
INATOMI Tsutomu 京都府立医科大学, 医学(系)研究科(研究院), 助教 (00305583)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAWASAKI Satoshi 大阪大学, 医学(系)研究科(研究院, 講師 (60347458)
MARUYAMA Kzuichi 東北大学, 大学病院, 講師 (10433244)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 再生医療 / 角膜上皮 / 口腔粘膜上皮 / 眼表面再建 / 細胞分化 / 血管新生 / 新生血管 / 新生血管因子 |
|---|
| Research Abstract |
Ocular surface reconstruction using tissue-engineered epithelial transplantation is a new therapeutic modality to overcome severe ocular surface disorders. Oral mucosal epithelium has a high proliferative capacity and similarity with ocular surface suggesting the possible use of alternative epithelium. In this study we have demonstrated that cultivated oral mucosal epithelial transplantation improved the clinical outcome. Biological characters and gene expression patterns of ocular surface epithelium and oral mucosal epithelium were analyzed. Cultivation of oral mucosal epithelium induced the different gene expression profiles, however, the phenotype of surviving transplanted oral mucosal epithelium was the same as in vivo oral mucosal epithelium suggesting that cultivated oral mucosal epithelium does not transdifferentiate into corneal epithelium. These basic findings were expected to contribute for further understanding for ocular surface mechanisms and developing a new therapy.
|
Report
(4 results)
Research Products
(51 results)
-
-
-
-
-
-
-
[Journal Article] Interaction between conjunctival epithelial cells and mast cells induces CCL2 expression and piecemeal degranulation in mast cells2013
Author(s)
Iwamoto S, Asada Y, Ebihara N, Hori K, Okayama Y, Kashiwakura J, Watanabe Y, Kawasaki S, Yokoi N, Inatomi T, Shinomiya K, Murakami A, Matsuda A
-
Journal Title
Invest Ophthalmol Vis Sci
Volume: 54(4) (PMID:23482464)
Pages: 2465-73
Related Report
Peer Reviewed
-
-
[Journal Article] Visual improvement after cultivated oral mucosal epithelial transplantation2013
Author(s)
Sotozono C, Inatomi T, Nakamura T, Koizumi N, Yokoi N, Ueta M, Matsuyama K, Miyakoda K, Kaneda H, Fukushima M, Kinoshita S
-
Journal Title
Ophthalmology
Volume: 120(1)
Pages: 193-200
Related Report
Peer Reviewed
-
-
-
[Journal Article] Visual improvement after cultivated oral mucosal epithelial transplantation.2013
Author(s)
Sotozono C, Inatomi T, Nakamura T, Koizumi N, Yokoi N, Ueta M, Matsuyama K, Miyakoda K, Kaneda H, Fukushima M, Kinoshita S.
-
Journal Title
Ophthalmology.
Volume: 120(1)
Pages: 193-200
Related Report
Peer Reviewed
-
[Journal Article] Visual improvement after cultivated oral mucosal epithelial transplantation.2013
Author(s)
Sotozono C, Inatomi T, Nakamura T, Koizumi N, Yokoi N, Ueta M, Matsuyama K, Miyakoda K, Kaneda H, Fukushima M, Kinoshita S.
-
Journal Title
Ophthalmology
Volume: 120(1)
Pages: 193-200
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Comparison of corneal and aqueous humor penetration of moxifloxacin, gatifloxacin and levofloxacin during keratoplasty2012
Author(s)
Fukuda M, Yamada M, Kinoshita S, Inatomi T, Ohashi Y, Uno T, Shimazaki J, Satake Y, Maeda N, Hori Y, Nishida K, Kubota A, Nakazawa T, Shimomura Y
-
Journal Title
Adv Ther
Volume: 29(4) (PMID:22529026)
Pages: 339-49
Related Report
Peer Reviewed
-
[Journal Article] Epistatic interaction between Toll-like receptor 3 (TLR3) and prostaglandin E receptor 3 (PTGER3) genes2012
Author(s)
Ueta M, Tamiya G, Tokunaga K, Sotozono C, Ueki M, Sawai H, Inatomi T, Matsuoka T, Akira S, Narumiya S, Tashiro K, Kinoshita S
-
Journal Title
J Allergy Clin Immunol
Volume: 129(5) (PMID:22421267)
Pages: 1413-1416
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Mathematical projection model of visual loss due to fuchs corneal dystrophy2011
Author(s)
Hatou S, Shimmura S, Shimazaki J, Usui T, Amano S, Yokogawa H, Kobayashi A, Zheng X, Shiraishi A, Ohashi Y, Inatomi T, Tsubota K
-
Journal Title
Invest Ophthalmol Vis Sci
Volume: 52(11) (PMID:21873666)
Pages: 7888-93
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
