Lrig family controls corneal stem cell homeostasis
| Project/Area Number |
23592621
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Doshisha University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 上皮幹細胞 / 角膜 / EGFR / Lrig / 眼表面 / LRIG |
|---|
| Research Abstract |
Corneal integrity and transparency is indispensable for good vision. The findings of this present study show that Lrig1 was highly expressed in the holoclone-type corneal epithelial stem cell population, and that Lrig1 was sporadically expressed in the basal cells of ocular-surface epithelium to regulate corneal epithelial cell fate during wound repair. Loss of Lrig1 resulted in impaired recruitment of stem cells post wounding, and in the cell-fate switch from transparent epithelium to keratinized skin-like epidermis, leading to corneal blindness. Lrig1 controlled corneal cell fate during repair by negatively regulating the STAT3-dependent inflammatory pathway, and blocking STAT3 rescued the pathological phenotypes observed in Lrig1 KO corneas. Here, we demonstrate that Lrig1 orchestrates corneal-tissue transparency and cell fate during repair.
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Report
(4 results)
Research Products
(72 results)
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[Journal Article] LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis2014
Author(s)
Nakamura T, Hamuro J, Takaishi M, Simmons S, Maruyama K, Zaffalon A, Bentley AJ, Kawasaki S, Nagata-Takaoka M, Fullwood NJ, Itami S, Sano S, Ishii M, Barrandon Y, Kinoshita S
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Journal Title
J Clin Invest.
Volume: 124(1)
Pages: 385-397
Related Report
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[Journal Article] LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis2014
Author(s)
Nakamura T, Hamuro J, Takaishi M, Simmons S, Maruyama K, Zaffalon A, Bentley AJ, Kawasaki S, Nagata-Takaoka M, Fullwood NJ, Itami S, Sano S, Ishii M, Barrandon Y, Kinoshita S.
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Journal Title
J Clin Invest
Volume: １
Issue: 1
Pages: 385-97
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Visual improvement following cultivated oral mucosal epithelial transplantation2013
Author(s)
Sotozono C, Inatomi T, Nakamura T, Koizumi N, Yokoi N, Ueta M, Matsuyama K, Miyakoda K, Kaneda H, Fukushima M, Kinoshita S
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Journal Title
Ophthalmology
Volume: 120(1)
Pages: 193-200
Related Report
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[Journal Article] Visual Improvement after Cultivated Oral Mucosal Epithelial Transplantatio2013
Author(s)
Sotozono C, Inatomi T, Nakamura T, Koizumi N, Yokoi N, Ueta M, Matsuyama K, Miyakoda K, Kaneda H, Fukushima M, Kinoshita S
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Journal Title
Ophthalmol, Peer-Reviewed papers
Volume: 120(1)
Issue: 1
Pages: 193-200
DOI
Related Report
Peer Reviewed
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[Journal Article] 羊膜移植の適応と効果2012
Author(s)
日野智之, 外園千恵, 稲富勉, 福岡秀記, 中村隆宏, 永田真帆, 小泉範子, 森和彦, 横井則彦, 木下茂
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Journal Title
日本眼科学会雑誌
Volume: 116(4)
Pages: 374-378
NAID
Related Report
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[Presentation] LRIG1による角膜の恒常性維持機構の解析2014
Author(s)
中村隆宏, 羽室淳爾, 高石樹朗, 丸山和一, 永田真帆, 川崎論, 板見智, 佐野栄紀, 石井優, 木下茂
Organizer
角膜カンファランス2014(第38回日本角膜学会総会・第30回日本角膜移植学会)
Place of Presentation
沖縄
Year and Date
2014-01-31
Related Report
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[Presentation] 角膜扁平上皮癌におけるGPR49の発現の検討2012
Author(s)
平田香菜, 中村隆宏, 外園千恵, 稲富勉, 奥村直毅, 小泉範子, 横井則彦, 木下茂
Organizer
角膜カンファランス2012(第36回日本角膜学会総会・第28回日本角膜移植学会)
Place of Presentation
東京
Year and Date
2012-02-23
Related Report
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[Presentation] LRIG1による角膜の恒常性維持機構の解析
Author(s)
中村隆宏, 羽室淳爾, 高石樹朗, 丸山和一, 永田真帆, 川崎論, 板見智, 佐野栄紀, 石井優, 木下茂
Organizer
角膜カンファランス2014（第38回日本角膜学会総会・第30回日本角膜移植学会）
Place of Presentation
沖縄
Related Report
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[Presentation] 先進医療としての羊膜移植の現状と有効性
Author(s)
森川恵輔, 外園千恵, 稲富勉, 中村隆宏, 横井則彦, 松尾俊康, 木下茂
Organizer
角膜カンファランス2014（第38回日本角膜学会総会・第30回日本角膜移植学会）
Place of Presentation
沖縄
Related Report
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