| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
Hepatic stellate cells (HSCs) store vitamin A and they are also known to be responsible for liver fibrosis. In child short bowel patients, oral administration of omega-3 fatty acids reduced the number of activated HSCs. Using HSCs isolated and cultured from rat liver, addition of omega-3 fatty acids accelerated formation of lipid droplets and decreased the expression levels of alpha-smooth muscle actin and type I collagen mRNAs.
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