Research Project
Grant-in-Aid for Scientific Research (C)
The prognosis of patients with pediatric malignant solid tumors have dramatically improved, although a part of these tumors are yet aggressive and fatal. Survivors suffer from grave side effects as a result of multimodal therapy, and the QOL of these patients are not satisfactory. In the present preclinical study, we aimed to develop a novel therapeutic approach for these tumors. NKT cells were detected in tumor-burden patients and were expandable in vitro. These cells showed significant cytotoxicity against neuroblastoma cell lines. Clinical implication of NKT mediated immunotherapy is awaited on the basis of these results.
All 2014 2013 2012 2011 Other
All Journal Article (25 results) (of which Peer Reviewed: 14 results, Open Access: 2 results) Presentation (8 results)
Eur J Cancer
Volume: 50 Pages: 1555-1565
Volume: 50 Issue: 8 Pages: 1555-1565
10.1016/j.ejca.2014.01.023
Int J Clin Oncol
Volume: 18 Pages: 962-968
Pediatr Surg Int
Volume: 29 Pages: 1077-1082
Front Immunol
Volume: 2 Pages: 409-409
International Journal of Clinical Oncology
Volume: 18 Issue: 6 Pages: 962-968
10.1007/s10147-013-0625-7
Pediatric Surgery International
Volume: 29 Issue: 10 Pages: 1071-1075
10.1007/s00383-013-3399-0
Volume: 29 Issue: 10 Pages: 1077-1082
10.1007/s00383-013-3400-y
Cancer Sci
Volume: 104 Issue: 5 Pages: 563-572
10.1111/cas.12115
J Pediatr Surg
Volume: 47 Pages: 2194-2198
Proc Natl Acad Sci U S A
Volume: 109 Pages: 16992-16997
J Clin Immunol
Volume: 32 Pages: 1071-1081
Journal of Pediatric Surgery.
Volume: 47 Issue: 12 Pages: 2194-2198
10.1016/j.jpedsurg.2012.09.006
Proc. Natl. Acad. Sci. USA
Volume: 109 Issue: 42 Pages: 16992-16997
10.1073/pnas.1203494109
Nat. Immunol
Volume: 13(8) Issue: 8 Pages: 778-786
10.1038/ni.2362
J Clin Immunol.
Volume: 32 Issue: 5 Pages: 1071-81
10.1007/s10875-012-9697-9
Leuk.Lymphoma
Volume: 53 Issue: 3 Pages: 479-486
10.3109/10428194.2011.625099
Cancer Res
Volume: 72 Issue: 17 Pages: 4587-4596
10.1158/0008-5472.can-12-0943
Clin Immunol
Volume: 140 Pages: 167-176
Volume: 138 Pages: 256-265
Cancer Immunol Immunother
Volume: 60 Pages: 207-215
Clin Immunol.
Volume: 138 Pages: 255-265