Development of a novel therapeutic approach for pediatric malignant solid tumors using NKT cell-mediated immune system
| Project/Area Number |
23592624
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Chiba Cancer Center (Research Institute) (2013)
Chiba University (2011-2012) |
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Principal Investigator |
HISHIKI TOMORO 千葉県がんセンター(研究所), 発がん研究グループ, 主任医長 (00375776)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Hideo 千葉大学, 大学院医学研究院, 教授 (60210712)
MOTOHASHI Shinichiro 千葉大学, 大学院医学研究院, 教授 (60345022)
KAMIJO Takehiko 千葉県がんセンター, 発がん研究部, 部長 (90262708)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経芽腫 / 免疫療法 / NKT細胞 / 小児悪性固形腫瘍 |
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| Research Abstract |
The prognosis of patients with pediatric malignant solid tumors have dramatically improved, although a part of these tumors are yet aggressive and fatal. Survivors suffer from grave side effects as a result of multimodal therapy, and the QOL of these patients are not satisfactory. In the present preclinical study, we aimed to develop a novel therapeutic approach for these tumors. NKT cells were detected in tumor-burden patients and were expandable in vitro. These cells showed significant cytotoxicity against neuroblastoma cell lines. Clinical implication of NKT mediated immunotherapy is awaited on the basis of these results.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Optimal surgical treatment and urological outcomes in boys with pelvic and urogenital rhabdomyosarcomas and soft tissue sarcomas2013
Author(s)
Hishiki T, Saito T, Mitsunaga T, Nakata M, Terui E, Komatsu S, Mise N, Harada K, Iwai J, Higashimoto Y, Okimoto Y, Kakuda H, Ochiai H, Hino M, Homma S, Osa Y, Yoshida H
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Journal Title
Pediatr Surg Int
Volume: 29
Pages: 1077-1082
Related Report
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[Journal Article] A cisplatin plus pirarubicin-based JPLT2 chemotherapy for hepatoblastoma : experience and future of the Japanese Study Group for Pediatric Liver Tumor (JPLT)2013
Author(s)
Hiyama E, Ueda Y, Onitake Y, Kurihara S, Watanabe K, Hishiki T, Tajiri T, Ida K, Yano M, Kondo S, Oue T; Japanese Study Group for Pediatric Liver Tumor
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Journal Title
Pediatric Surgery International.
Volume: 29
Pages: 1071-1075
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Optimal surgical treatment and urological outcomes in boys with pelvic and urogenital rhabdomyosarcomas and soft tissue sarcomas.2013
Author(s)
Hishiki T, Saito T, Mitsunaga T, Nakata M, Terui E, Komatsu S, Mise N, Harada K, Iwai J, Higashimoto Y, Okimoto Y, Kakuda H, Ochiai H, Hino M, Homma S, Osa Y, Yoshida H.Ｈ
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Journal Title
Pediatr Surg Int
Volume: 29
Pages: 1077-1082
DOI
Related Report
Peer Reviewed
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[Journal Article] The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T_H2 differentiation.2013
Author(s)
Kuwahara, M., Yamashita, M., Shinoda, K., Tofukuji, S., Onodera, A., Shinnakasu, R., Motohashi, S., Hosokawa, H., Tumes, D., Iwamura, C., Lefebvre, V., and Nakayama, T.
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Journal Title
Nat Immunol.
Volume: 13(8)
Pages: 4691-4696
DOI
Related Report
Peer Reviewed
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[Journal Article] Surgical strategies for unresectable hepato- blastomas2012
Author(s)
Tajiri T, Kimura O, Fumino S, Furukawa T, Iehara T, Souzaki R, Kinoshita Y, Koga Y, Suminoe A, Hara T, Kohashi K, Oda Y, Hishiki T, Hosoi H, Hiyama E, Taguchi T
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Journal Title
J Pediatr Surg
Volume: 47
Pages: 2194-2198
Related Report
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[Journal Article] Accumulation of activated invariant natural killer T cells in the tumor microenvironment afterα- galactosylceramide - pulsed antigen presenting cells2012
Author(s)
Nagato K, Motohashi S, Ishibashi F, Okita K, Yamasaki K, Moriya Y, Hoshino H, Yoshida S, Hanaoka H, Fujii S, Taniguchi M, Yoshino I, Nakayama T
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Journal Title
J Clin Immunol
Volume: 32
Pages: 1071-1081
Related Report
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[Journal Article] Regulation ofmemory CD4 T-cell pool size and function bynatural killer T cells in vivo2012
Author(s)
Iwamura, C., Shinoda, K., Endo, Y., Watanabe, Y., Tumes, J. D., Motohashi, S., Kawahara, K., Kinjo, Y., and Nakayama, T.
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Journal Title
Proc. Natl. Acad.Sci. USA
Volume: 109
Pages: 16992-16997
DOI
Related Report
Peer Reviewed
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[Journal Article] Accumulation of activated invariant natural killer T cells in the tumor microenvironment after α-Galactosylceramide-pulsed antigen presenting cells.2012
Author(s)
Nagato K, Motohashi S, Ishibashi F, Okita K, Yamasaki K, Moriya Y, Hoshino H, Yoshida S, Hanaoka H, Fujii SI, Taniguchi M, Yoshino I, Nakayama T.
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Journal Title
J Clin Immunol
Volume: 32
Pages: 1071-1081
DOI
Related Report
Peer Reviewed
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[Journal Article] MurineSchnurri-2 controls Natural Killer cell function and lymphoma development.2012
Author(s)
Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., Tanaka, H., Kaneko, K., Hanazawa, A., Watanabe, Y., Shinoda, K., Tumes, D., Motohashi, S., Nakayama, T.
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Journal Title
Leuk Lymphoma.
Volume: 53
Pages: 476-486
DOI
Related Report
Peer Reviewed
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[Presentation] 神経芽腫細胞に対するNKT細胞によるADCC増強効果の検討2013
Author(s)
三瀬 直子, 菱木 知郎, 斎藤 武, 照井 慶太, 光永 哲也, 中田 光政, 國井 直樹, 藤川 陽, 堀中 敦史, 鎌田 稔子, 蒔田 勇治, 内田 亮介, 伊原 史英, 吉田 英生, 本橋 新一郎
Organizer
第55回 日本小児血液・がん学会学術集会
Place of Presentation
福岡
Related Report
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[Presentation] 神経芽腫細胞に対するNKT細胞によるADCC増強効果の検討
Author(s)
三瀬直子, 菱木知郎, 斎藤武, 照井慶太, 光永哲也, 中田光政, 國井直樹, 藤川陽, 堀中敦史, 鎌田稔子, 蒔田勇治, 内田亮介, 伊原史英, 吉田英生, 本橋新一郎
Organizer
第55回日本小児血液・がん学会学術集会
Related Report
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