The establishment of the novel immunotherapy for neuroblastoma using transgenic mouse
| Project/Area Number |
23592631
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TAJIRI TATSURO 京都府立医科大学, 医学(系)研究科(研究院), 教授 (80304806)
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| Co-Investigator(Kenkyū-buntansha) |
TGUCHI Tomoaki 九州大学, 医学(系)研究科, 教授 (20197247)
YONEMITSU Yosikazu 九州大学, 薬学研究科, 教授 (40315065)
KADOMATSU Kenji 名古屋大学, 医学(系)研究科, 教授 (80204519)
田中 桜 九州大学, 医学(系)研究科(研究院), 研究員 (40467923)
宗崎 良太 九州大学, 大学病院, 助教 (10403990)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 小児がん / 神経芽腫 / 免疫治療 / センダイウイルス / 樹状細胞 / センダイウィルス / MYCNトランスジェニックマ ウス / 放射線照射 / MYCNトランスジェニックマウス |
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| Outline of Final Research Achievements |
To establish the novel treatment for neuroblastoma, we assessed the anti tumor effect and the analysis of mechanism of the immunotherapy with local radiation by Sendai Virus/Dendritic cel for neuroblastoma using MYCN transgenic mouse. The anti tumor effect for neuroblastoma of he immunotherapy with local radiation by SeV/DC was demonstrated. The possibility was suggested that the NK cell and CD4 positive T-cell was the primitive effector cells for this immunotherapy.
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Report
(5 results)
Research Products
(51 results)
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[Journal Article] Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma2013
Author(s)
Rumbajan JM, Maeda T, Souzaki R, Mitsui K, Higashimoto K, Nakabayashi K, Yatsuki H, Nishioka K, Harada R, Aoki S, Kohashi K, Oda Y, Hata K, Saji T, Taguchi T, Tajiri T, Soejima H, Joh K.
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Journal Title
BMC Cancer
Volume: 13
Issue: 1
Pages: 608-619
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A cisplatin plus pirarubicin-based JPLT2 chemotherapy for hepatoblastoma: experience and future of the Japanese Study Group for Pediatric Liver Tumor (JPLT)2013
Author(s)
Hiyama E, Ueda Y, Onitake Y, Kurihara S, Watanabe K, Hishiki T, Tajiri T, Ida K, Yano M, Kondo S, Oue T; Japanese Study Group for Pediatric Liver Tumor
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Journal Title
Pediatric Surgery International
Volume: 29
Issue: 10
Pages: 1071-1075
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Surgical strategies for unresectable hepatoblastomas.2012
Author(s)
Tajiri T, Kimura O, Fumino S, Furukawa T, Iehara T, Souzaki R, Kinoshita Y, Koga Y, Suminoe A, Hara T, Kohashi K, Oda Y, Hishiki T, Hosoi H, Hiyama E, Taguchi T
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Journal Title
J Pediatr Surg
Volume: 47
Pages: 2194-98
Related Report
Peer Reviewed
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