| Project/Area Number |
23592631
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TAJIRI TATSURO 京都府立医科大学, 医学(系)研究科(研究院), 教授 (80304806)
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| Co-Investigator(Kenkyū-buntansha) |
TGUCHI Tomoaki 九州大学, 医学(系)研究科, 教授 (20197247)
YONEMITSU Yosikazu 九州大学, 薬学研究科, 教授 (40315065)
KADOMATSU Kenji 名古屋大学, 医学(系)研究科, 教授 (80204519)
田中 桜 九州大学, 医学(系)研究科(研究院), 研究員 (40467923)
宗崎 良太 九州大学, 大学病院, 助教 (10403990)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 小児がん / 神経芽腫 / 免疫治療 / センダイウイルス / 樹状細胞 / センダイウィルス / MYCNトランスジェニックマ ウス / 放射線照射 / MYCNトランスジェニックマウス |
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| Outline of Final Research Achievements |
To establish the novel treatment for neuroblastoma, we assessed the anti tumor effect and the analysis of mechanism of the immunotherapy with local radiation by Sendai Virus/Dendritic cel for neuroblastoma using MYCN transgenic mouse. The anti tumor effect for neuroblastoma of he immunotherapy with local radiation by SeV/DC was demonstrated. The possibility was suggested that the NK cell and CD4 positive T-cell was the primitive effector cells for this immunotherapy.
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