| Project/Area Number |
23592634
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SEKI Yasuji 聖マリアンナ医科大学, 医学部, 講師 (20309462)
KOIKE Junki 聖マリアンナ医科大学, 医学部, 准教授 (40308440)
AOBA Takeshi 聖マリアンナ医科大学, 医学部, 助教 (90571696)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | Obstructive uropathy / Fetal surgery / Urinoma / V-P shunt / 胎児手術 / 尿路閉塞 / 多嚢腎 / 膀胱機能 / 排尿障害 / 胎児尿路閉塞 / 膀胱羊水腔シャント / 胎児治療 / 後部尿道弁 / 胎児水腎症 / 急性尿細管壊死 |
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| Research Abstract |
A valved ventriculo-peritoneal shunt (V-P shunt) as a vesico-amniotic shunt (V-A shunt) preserves the filling/emptying cycle and normal bladder development in fetallambs with bladder outlet obstruction. We created obstructive uropathy in 60-day gestation fetal lambs.A V-A shunt was placed 3 weeks later,using a low-pressure (L:15-54 mm H2O) or a high-pressure (H:95-150 mm H2O) V-P shunt. We included non-shunted (O) and control (C) lambs. All were delivered at 130 days. Bladder volumes,bladder thickness, renal and bladder histology were compared. Five Group L (4 survived),four Group H (3 survived) and 5 Group O survived.Group H lambs had a dilated urachus,urinary ascites and severe ureteral dilatation similar to Group O lambs. There were 4 Group C lambs. Bladder volume was 10,15 and 1,150ml in Group H,115+-67.9 ml in Group L,128+-99.8 ml in Group O and 24.5+-3.84 ml in Group C.Low-pressure shunts preserved both bladder volume and renal development. High-pressure shunts did neither.
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