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Low-energy extracorporeal shock wave therapy enhances skin wound healing in diabetic mice: a critical role of endothelial nitric oxide synthase.

Research Project

Project/Area Number 23592639
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Plastic surgery
Research InstitutionTohoku University

Principal Investigator

IMAI Yoshimichi  東北大学, 医学(系)研究科(研究院), 准教授 (80323012)

Co-Investigator(Kenkyū-buntansha) ITOU Kenta  東北大学, 大学院医学系研究科, 准教授 (50375086)
KAWAKAMI Kazuyoshi  東北大学, 大学院医学系研究科, 教授 (10253973)
TAKEDA Atsushi  東北大学, 大学院医学系研究科, 助教 (30333800)
KANNO Emi  東北大学, 大学院医学系研究科, 講師 (10431595)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords体外衝撃波治療 / 慢性創傷 / 血管新生 / 創傷治癒 / 対外衝撃波治療
Research Abstract

There is the country where low power outside the body shock wave treatment is really used for for a diabetic foot ulcer and a chronic leg ulcer in the Western European countries, but the authorization in this country is not done. The fundamental law can expect the role as the ace in the hole in the case that revascularizing it has difficult for diabetes, the arterial ischemia-related ulcer caused by the seriously ill ischemic limb (occlusive arteriosclerosis). The vascularization action was clarified through animal experiment. I pushed forward preparations for clinical application in parallel.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Low-energy extracorporeal shock wave therapy enhances skin wound healing in diabetic mice : a critical role of endothelial nitric oxide synthase2012

    • Author(s)
      Denso Hayashi, Kazuyoshi Kawakami, Kenta Ito, Keiko Ishii, Hiromasa Tanno, Yoshimichi Imai, Emi Kanno, Ryoko Maruyama, Hiroaki Shimokawa, and Masahiro Tachi
    • Journal Title

      WRR

      Volume: 20(6) Pages: 887-95

    • NAID

      10031181879

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low-energy extracorporeal shock wave therapy enhances skin wound healing in diabetic mice: a critical role of endothelial nitric oxide synthase2012

    • Author(s)
      Denso Hayashi
    • Journal Title

      Wound Repair Regen.

      Volume: 20 Pages: 887-95

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] STZ誘発糖尿病モデル慢性皮膚潰瘍に対する低出力体外衝撃波治療の有効性の検討について2012

    • Author(s)
      林殿聡,川上和義,伊藤健太,下川宏明,館正弘
    • Organizer
      第55回形成外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-12
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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