| Project/Area Number |
23592640
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
LEE Yang Sung 東北大学, 医学(系)研究科(研究院), 非常勤講師 (90466566)
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| Co-Investigator(Kenkyū-buntansha) |
IMAI Yoshimichi 東北大学, 医学系研究科, 准教授 (80323012)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 同種混合組織移植 / 小胞体ストレス反応 / 再建外科 / 関節軟骨 |
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| Research Abstract |
To observe the involvement of endoplasmic retinaculum stress response in acute rejection, we focused the articular cartilage in rat lower limb composite tissue allotransplantation model that had not been rejected so far. However apoptotic chondrocytes were increased in a few days after allotransplantation, and caspase-3 positive ratio were also increased in allotransplantation group, therefore acute rejection was occurred to the articular cartilage in allotransplantation. Conversely heat shock protein (HSP) that were concerned acute rejection, were not increased, therefore we suggested the acute rejection mechanism of articular cartilage were differ from another tissue.
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