| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
Keloids are a dermal fibrotic disease whose etiology remains unknown.
To clarify the molecular mechanism of keloid pathogenesis, we focused on HtrA1, a serine protease-family protein to investigated roles of this protein in keloid pathogenesis. HtrA1 and whose substrate, Fibronectin were over-expressed in the keloid lesions, and fragmentation of Fibronectin was observed in keloid lesions. Knockdown of HtrA1 in keloid-derived fibroblasts lead to reduce cell prolifaration rate. Thus, HtrA1 may promote keloid development through matrix degradation
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