The development of 3D cartilage regeneration therapy using the human auricular cartilage progenitor cells with autologous serum.
| Project/Area Number |
23592650
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
KOBAYASHI Shinji 横浜市立大学, 医学(系)研究科(研究院), 客員准教授 (90464536)
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| Co-Investigator(Kenkyū-buntansha) |
MAEGAWA Jirou 横浜市立大学, 医学研究科, 教授 (70244449)
TANIGUCHI Hideki 横浜市立大学, 医学研究科, 教授 (70292555)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 軟骨前駆細胞 / 軟骨再生 / 軟骨膜細胞 / 軟骨膜 / 軟骨幹/前駆細胞 |
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| Research Abstract |
We have succeeded in isolating Human cartilage progenitor cells (hCPCs) and regenerating cartilage derived from them. The hCPCs which were isolated from auricular perichondrium had not only high proliferative and multipotent capacity that human chondrocytes (hCs) did not have, but had same cartilage extracellular matrix capacity as hCs.
Our purpose is to develop handing skill that could apply hCPCs in clinical setting on the basis of their culture technique. Specifically, there are (1) Implementation of hCPCs characterization (2) Evaluation of regenerated cartilage in vivo (3) The development of 3D cartilage regeneration derived from hCPCs (4) The development of autologous serum technique.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Reconstruction of joint hyaline cartilage by autologous progenitor cells derived from ear elastic cartilage2014
Author(s)
M Mizuno, S Kobayashi, T Takebe, H Kan, Y Yabuki, T Matsuzaki, H Y. Yoshikawa, S Nakabayashi, J,I Lee, J Maegawa, H Taniguchi
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Journal Title
Stem Cells
Volume: 32(3)
Pages: 816-21
Related Report
Peer Reviewed
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[Journal Article] Reconstruction of Joint Hyaline Cartilage by Autologous Progenitor Cell s Derived from Ear Elastic Cartilage2014
Author(s)
M. Mizuno, S. Kobayashi, T. Takebe, H. Kan, Y. Yabuki, T. Matsuzaki, H. Y. Yoshikawa, S. Nakabayashi, L. J. Ik, J. Maegawa, H. Taniguchi
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Journal Title
Stem Cells
Volume: 32
Issue: 3
Pages: 816-821
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Human elastic cartilage engineering from cartilage progenitor cells using rotating wall vessel bioreactor.2012
Author(s)
Takanori Takebe, Shinji Kobayashi, Hiroomi Kan, Hiromu Suzuki, Mitsuru Mizuno, Yuichiro Yabuki, Takuro Adegawa, Tomohiko Yoshioka , Junzo Tanaka, Jiro Maegawa, Hideki Taniguchi.
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Journal Title
Transplantation Proceedings
Volume: 44
Issue: 4
Pages: 1158-61
DOI
Related Report
Peer Reviewed
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[Presentation] Reconstruction of human elastic cartilage by progenitor cells in the ear perichondrium2012
Author(s)
Suzuki H, Kobayashi S, Takebe T, Mizuno M, Murata S, Yabuki Y, Hirotomi K, Yasumura K, Maegawa J, Taniguchi H
Organizer
International Society for Stem Cell Research 10^<th> annual meeting
Place of Presentation
Yokohama,Japan
Related Report
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[Presentation] Identification and utilization of human cartilage stem cells from the ear2011
Author(s)
Hiromu Suzuki, Shinji Kobayashi, Takanori Takebe, Mitsuru Mizuno,Yuichiro Yabuki, Kazumusa Yasumura, Syunsuke Murata,Jiro Maegawa, Hideki Taniguchi
Organizer
12th Congress of the Asian Society of Transplantation,
Place of Presentation
Seoul, Korea
Related Report
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[Book] シーエムシー出版2011
Author(s)
小林眞司、谷口英樹
Total Pages
6
Publisher
軟骨再生医療：こどもの心をいやす医療に向けて
Related Report
