Development of the device for healing ability of diabetic and ischemic ulcers

• Project/Area Number: 23592652
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Saitama Medical University
• Principal Investigator: ICHIOKA Shigeru 埼玉医科大学, 医学部, 教授 (60306272)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 創傷治癒

Research Abstract

Chronic wounds due to diabetes mellitus (DM) and/or peripheral arterial disease (PAD) often occur in the pedal region peripheral to the ankle. To predict wound healing potential of the limb ulcers, skin perfusion pressure (SPP) and transcutaneous oxygen tension (TcPO2) have recently become popular as the parameters that reflect skin microcirculation. On the other hand, ultrasonography for the macrocirculatory vessels has already prevailed widely as the standard vascular investigation. The skin microcirculation peripheral to the ankle probably depends on the macrocirculatory blood flow at the ankle level. Thus, this study aims to estimate weather the blood flow of the anterior tibial artery (ATA) and the posterior tibial artery at the ankle level reflect the values of SPP and TcPO2 on the foot. .

Research Products

• [Journal Article] 下肢潰瘍に対する足関節レベルの血管超音波検査の有用性 (2014)
  • Author(s): 関谷直美、市岡滋
  • Journal Title: 皮膚微小循環血流との比較脈管学 Volume: 54 Pages: 45-50
• [Journal Article] Comparison of collagen matrix treatment impregnated with platelet rich plasma vs bone marrow. (2014)
  • Author(s): Minamimura A, Ichioka S, Sano H, Sekiya N.
  • Journal Title: J Plast Surg Hand Surg. Volume: Feb;48(1) Issue: 1 Pages: 15-20
  • DOI: 10.3109/2000656x.2013.793193
  • Peer Reviewed
• [Journal Article] Which cleansing care is better, foot bath or shower? Analysis of 236 limb ulcers. (2013)
  • Author(s): Sano H, Ichioka S.
  • Journal Title: Int Wound J Volume: Nov 20 Issue: 5 Pages: 577-580
  • DOI: 10.1111/iwj.12167
  • Peer Reviewed
• [Journal Article] Preservation of the properties of elastic plasma protein plus platelet film for wound dressing. (2013)
  • Author(s): Sano H, Ichioka S, Minamimura A, Tanaka R, Ikebuchi K, Suzuki M.
  • Journal Title: J Plast Surg Hand Surg. Volume: Dec;47(6): Pages: 458-61
  • DOI: 10.3109/2000656x.2013.779582
  • Peer Reviewed
• [Journal Article] Treatment of chronic ulcer with elastic plasma protein and platelet film for wound dressing. (2013)
  • Author(s): Sano H, Ichioka S, Minamimura A, Tanaka R, Ikebuchi K, Suzuki M.
  • Journal Title: J Plast Surg Hand Surg. Volume: Dec;47(6) Pages: 462-6
  • DOI: 10.3109/2000656x.2013.783485
  • Peer Reviewed
• [Journal Article] Efficacy of a poly glycolic acid (PGA)/collagen composite nanofibre scaffold on cell migration and neovascularisation in vivo skin defect model. (2013)
  • Author(s): Sekiya N, Ichioka S, Terada D, Tsuchiya S, Kobayashi H.
  • Journal Title: J Plast Surg Hand Surg. Volume: Dec;47(6) Pages: 498-502
  • DOI: 10.3109/2000656x.2013.788507
  • Peer Reviewed
• [Journal Article] Involvement of nitric oxide in the wound bed microcirculatory change during negative pressure wound therapy. (2013)
  • Author(s): Sano H, Ichioka S.
  • Journal Title: Int Wound J. Volume: Jul 9. Issue: 4 Pages: 397-401
  • DOI: 10.1111/iwj.12121
  • Peer Reviewed
• [Journal Article] The effect of a hydrocolloid dressing containing ceramide-2 on split-thickness wounds in a laser-induced erosion model (2013)
  • Author(s): Tsuchiya S, Ichioka S, Sekiya N, Tajima S, Iwasaki T, Numata S
  • Journal Title: Adv Skin Wound Care Volume: 26(5) Issue: 5 Pages: 224-9
  • DOI: 10.1097/01
  • Peer Reviewed
• [Journal Article] The effect of a hydrocolloid dressing containing ceramide-2 on split-thickness wounds in a laser-induced erosion model. (2013)
  • Author(s): Tsuchiya S, Ichioka S, Sekiya N, Tajima S, Iwasaki T, Numata S.
  • Journal Title: Adv Skin Wound Care. Volume: May;26(5) Issue: 5 Pages: 224-9
  • DOI: 10.1097/01.asw.0000428952.00149.77
  • Peer Reviewed
• [Journal Article] How should we manage multiple skin ulcers associated with calciphylaxis? (2012)
  • Author(s): Sato T, Ichioka S
  • Journal Title: J Dermatol Volume: (In press) Issue: 11 Pages: 966-968
  • DOI: 10.1111/j.1346-8138.2012.01510.x
  • Peer Reviewed
• [Journal Article] Treatment of venous ulcers with bone marrow-impregnated collagen matrix. (2012)
  • Author(s): Sano H, Ichioka S, Kouraba S, Minamimura A, Sato T, Sekiya N, Yasuta M.
  • Journal Title: J Plast Surg Hand Surg. Volume: 46 Issue: 1 Pages: 37-44
  • DOI: 10.3109/2000656x.2011.633392
  • Peer Reviewed
• [Journal Article] Optimal use of negative pressure wound therapy in treating (2012)
  • Author(s): Gupta S, Ichioka S.
  • Journal Title: Int Wound J. Volume: 9 Issue: s1 Pages: 8-16
  • DOI: 10.1111/j.1742-481x.2012.01012.x
  • Peer Reviewed
• [Journal Article] The estimation of tissue loss during tangential hydrosurgical debridement (2012)
  • Author(s): Matsumura H, Nozaki M, Watanabe K, Sakurai H, Kawakami S, Nakazawa H, Matsumura I, Katahira J, Inokuchi S, Ichioka S, Ikeda H, Mole T, Smith J, Martin R, Aikawa N
  • Journal Title: Ann Plast Surg Volume: 69(5) Issue: 5 Pages: 521-5
  • DOI: 10.1097/sap.0b013e31826d2961
• [Journal Article] Influence of mechanical forces as a part of nail configuration (2012)
  • Author(s): Sano H, Ichioka S
  • Journal Title: Dermatology Volume: 225(3) (Epub 2012 Nov 6) Issue: 3 Pages: 210-4
  • DOI: 10.1159/000343470
• [Journal Article] Influence of oxygen on wound healing dynamics : assessment in a novel wound mouse model under a variable oxygen environment (2012)
  • Author(s): Sano H, Ichioka S, Sekiya N
  • Journal Title: PLoS One Volume: 7(11) (Epub 2012 Nov 28) Issue: 11 Pages: e50212-e50212
  • DOI: 10.1371/journal.pone.0050212
• [Journal Article] Treatment of venous ulcers with bone marrow-impregnated collagen matrix. (2012)
  • Author(s): Sano H, Ichioka S, Kouraba S, Minamimura A, Sato T, Sekiya N, Yasuta M.
  • Journal Title: J Plast Surg Hand Surg. Volume: 46 Pages: 37-44
  • Peer Reviewed
• [Journal Article] Pressure ulcer occurrence following the great East Japan earthquake: observations from a disaster medical assistance team . (2012)
  • Author(s): Sato T, Ichioka S.
  • Journal Title: Ostomy Wound Manage. Volume: 58 Pages: 70-75
  • Peer Reviewed
• [Journal Article] In vivo analysis of skin microcirculation and the role of nitric oxide during vibration. (2012)
  • Author(s): Ichioka S, Yokogawa H, Nakagami G, Sekiya N, Sanada H.
  • Journal Title: Ostomy Wound Manage. Volume: 57 Pages: 40-47
  • Peer Reviewed
• [Presentation] Diversity in Surgical Wound Management (2014)
  • Author(s): 市岡滋
  • Organizer: 第57回日本形成外科学会学術集会
  • Place of Presentation: 長崎ブリックホール
  • Year and Date: 2014-04-10
• [Presentation] 創傷をgateとしたチーム医療の作り方 (2014)
  • Author(s): 市岡滋
  • Organizer: 第12回日本フットケア学会年次学術集会
  • Place of Presentation: なら100年記念館
  • Year and Date: 2014-03-07
• [Presentation] 褥瘡・難治性創傷の最新治療 (2014)
  • Author(s): 市岡滋
  • Organizer: 第10回日本褥瘡学会中部地方会学術集会
  • Place of Presentation: アクトシティー浜松
  • Year and Date: 2014-03-02
• [Presentation] 下肢創傷管理技術の最先端 (2014)
  • Author(s): 市岡滋
  • Organizer: 第4回大阪循環器病懇話会
  • Place of Presentation: ヒルトンホテル大阪
  • Year and Date: 2014-02-23
• [Presentation] 創傷治療のup to date (2013)
  • Author(s): 市岡滋
  • Organizer: 第105回関西形成外科学会学術集会
  • Place of Presentation: 大阪市立大学
  • Year and Date: 2013-12-07
• [Presentation] Diabetic Footにおける創傷管理のupdate (2013)
  • Author(s): 市岡滋
  • Organizer: 第28回日本糖尿病合併症学会
  • Place of Presentation: 旭川グランドホテル
  • Year and Date: 2013-09-13
• [Presentation] 医師と看護師が伝授する創傷マネージメントのup to date (2013)
  • Author(s): 市岡滋
  • Organizer: 第15回日本褥瘡学会学術集会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2013-07-20
• [Presentation] VAC ATS治療システムUpdate (2013)
  • Author(s): 市岡滋
  • Organizer: 第56回日本形成外科学会総会・学術集会
  • Place of Presentation: 京王プラザ
  • Year and Date: 2013-04-04
• [Presentation] 褥瘡・難治性創傷の最新治療 (2012)
  • Author(s): 市岡滋
  • Organizer: 第27回日本静脈経腸栄養学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2012-02-24
• [Presentation] Japanese Experience in VAC Optimal Use of NPWT in treating Pressure Ulcers (2012)
  • Author(s): Ichioka S
  • Organizer: The 4^<th> Congress of World Union of Wound Healing Society
  • Place of Presentation: Pacifico Yokohama
• [Presentation] The Implications for Innovation in NPWT (2012)
  • Author(s): Ichioka S
  • Organizer: The 4^<th> Congress of World Union of Wound Healing Society
  • Place of Presentation: Pacifico Yokohama
• [Presentation] HISTORY AND PRESENT STATUS OF NPWT IN JAPAN (2012)
  • Author(s): Ichioka S
  • Organizer: The 4^<th> Congress of World Union of Wound Healing Society
  • Place of Presentation: Pacifico Yokohama
• [Presentation] The Brief History of Negative Pressure Wound Therapy (2012)
  • Author(s): Ichioka S
  • Organizer: The 4^<th> Congress of World Union of Wound Healing Society
  • Place of Presentation: Pacifico Yokohama
• [Presentation] Clinical Evidence with Silver Dressing Technology (2012)
  • Author(s): Ichioka S
  • Organizer: The 4^<th> Congress of World Union of Wound Healing Society
  • Place of Presentation: Pacifico Yokohama
• [Book] 創傷のすべて (市岡滋監修、安部正敏、寺師浩人、溝上祐子編集) (2012)
  • Publisher: 克誠堂