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Development of prevention adhesion sheet composed of hyaluronic acid and collagen sponge containing epidermal growth factor

Research Project

Project/Area Number 23592653
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Plastic surgery
Research InstitutionKitasato University

Principal Investigator

NEMOTO Mitsuru  北里大学, 医学部, 講師 (20276083)

Co-Investigator(Kenkyū-buntansha) KUROYANAGI Yoshimitsu  北里大学, 医療衛生学部, 教授 (80170140)
KUMAZAWA Kenichi  北里大学, 医学部, 助教 (60383618)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords癒着防止膜 / ヒアルロン酸 / コラーゲン / 腱損傷 / 手外科 / 癒着防止
Research Abstract

The aim of this study has revealed effects of prevention adhesion sheet composed of hyaluronic acid and collagen sponge in chicken model. We presented effects of prevention adhesion sheet applied for tendon sheath injury in the 56th annual meeting of the Japanese society for surgery of the hand at Yokohama, and applied for tendon injury in the 57th annual meeting of the Japanese society for surgery of the hand at Kobe. However, prevention adhesion sheet applied tendon injury model of chicken occurred limitation of range of motion. Then, we have improved prevention adhesion sheet composed of hyaluronic acid and collagen sponge for postoperative early exercise. We will present these results of prevention adhesion sheet in 10th congress of Asian pacific federation of societies for surgery of the hand at Malaysia.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (27 results)

All 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 9 results) Presentation (15 results)

  • [Journal Article] Development on novel wound dressing composed of hyaluronic acid and collagen sponge containing epidermal growth factor and vitamin C derivative2014

    • Author(s)
      Niiyama H, Kuroyanagi Y
    • Journal Title

      J Artif Organs

      Volume: 17 Pages: 81-87

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential of wound dressing composed of hyaluronic acid containing epidermal growth factor to enhance cytokine production by fibroblasts2013

    • Author(s)
      Yamamoto A, Shimizu N, Kuriyanagi Y
    • Journal Title

      J Artif Organs

      Volume: 16 Issue: 4 Pages: 489-194

    • DOI

      10.1007/s10047-013-0726-0

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of an artificial dermis composed of hyaluronic acid and collagen2013

    • Author(s)
      Mineo A,Kuroyanagi Y
    • Journal Title

      J Biomater Sci Ploym Ed

      Volume: 24 Pages: 726-740

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Safety and utility of a PMMA-based tissue adhesive for closure of surgical incision wounds2013

    • Author(s)
      Suzuki R, Kuroyanagi Y
    • Journal Title

      J Biomater Sci Polym Ed

      Volume: 24 Issue: 6 Pages: 287-300

    • DOI

      10.1080/09205063.2012.708190

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential of a cryopreserved cultured dermal substitute composed of hyaluronic acid and collagen to release angiogenic cytokine2013

    • Author(s)
      Sawa M,Kuroyanagi Y
    • Journal Title

      J Biomater Sci Polym Ed

      Volume: 24 Issue: 2 Pages: 224-238

    • DOI

      10.1163/156856212x631888

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] アドバンスト・ウンド・マネジメントTHEテクニック生体材料・細胞成長因子・細胞を応用した新しい創傷治療2012

    • Author(s)
      黒柳能光
    • Journal Title

      日本創傷・オストミー・失禁管理学会誌

      Volume: 15 Pages: 270-270

    • Related Report
      2013 Final Research Report
  • [Journal Article] 皮膚筋炎に合併した右肘部難治性皮膚潰瘍の1例2012

    • Author(s)
      吉竹俊裕、根本 充、永島和貴、新美裕太、氷見和己、上原理恵、石川心介、内沼栄樹
    • Journal Title

      形成外科

      Volume: 55 Pages: 1375-1379

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 手指・手関節部に発症したガングリオン摘出術後再発例の検討2012

    • Author(s)
      熊澤憲一、根本 充、秋本峰克、石川心介、内沼栄樹
    • Journal Title

      日本手外科学会雑誌

      Volume: 28 Pages: 401-405

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 再生医療のいま基礎研究から臨床への展開に向けて細胞・細胞成長因子・生体材料を応用した皮膚再生医療2011

    • Author(s)
      黒柳能光
    • Journal Title

      治療

      Volume: 93 Pages: 1946-1952

    • Related Report
      2013 Final Research Report
  • [Journal Article] 細胞・細胞成長因子・生体材料を応用した皮膚再生医療2011

    • Author(s)
      黒柳能光
    • Journal Title

      日本創傷・オストミー・失禁管理学会誌

      Volume: 15 Pages: 16-24

    • NAID

      130008036779

    • Related Report
      2013 Final Research Report
  • [Journal Article] Reconstruction for a mucocele of an old frontal sinus fracture2011

    • Author(s)
      Yuta Niimi, Mitsuru Nemoto, Yasuyuki Oyatsu, Takeshi Nakamura, Eiju Uchinuma
    • Journal Title

      Kitasato Medical Journal

      Volume: 41 Pages: 84-89

    • NAID

      40018724985

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Medical Treatment for Burn Patients with Eating Disorders: A Case Report2011

    • Author(s)
      Minekatsu Akimoto, Akira Takeda, Kazutaka Nagashima, Rie Uehara, Mitsuru Nemoto, Eiju Uchinuma
    • Journal Title

      Plastic Surgery International

      Volume: 2011 Pages: 1-4

    • DOI

      10.1155/2011/370981

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ヒアルロン酸とコラーゲンを組み合わせた癒着防止膜の開発第2報−機能的評価—2013

    • Author(s)
      根本充、熊澤憲一、内沼栄樹
    • Organizer
      第56回日本手外科学会学術集会
    • Place of Presentation
      神戸市
    • Year and Date
      2013-04-19
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒアルロン酸とコラーゲンを組み合わせた新規癒着防止膜の開発第1報−組織学的評価−2012

    • Author(s)
      根本充、熊澤憲一、内沼栄樹
    • Organizer
      第55回日本手外科学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2012-04-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 母指内転拘縮解除に用いた皮弁の検討2011

    • Author(s)
      根本 充、熊澤憲一、石川心介、内沼栄樹
    • Organizer
      第54回日本手外科学会学術集会
    • Place of Presentation
      青森県青森市
    • Related Report
      2011 Research-status Report
  • [Presentation] 爪床損傷に対し付け爪を用いた治療経験2011

    • Author(s)
      山田直人、根本 充、内沼栄樹
    • Organizer
      第54回日本手外科学会学術集会
    • Place of Presentation
      青森県青森市
    • Related Report
      2011 Research-status Report
  • [Presentation] ガングリオン術後再発症例の検討2011

    • Author(s)
      熊澤憲一、根本 充、石川心介、内沼栄樹
    • Organizer
      第54回日本手外科学会学術集会
    • Place of Presentation
      青森県青森市
    • Related Report
      2011 Research-status Report
  • [Presentation] 救命救急センター専任形成外科医による熱傷治療2011

    • Author(s)
      根本 充、青柳和也、柏木慎也、秋本峰克、杉本孝之、石川心介、相馬一亥、内沼栄樹
    • Organizer
      第37回日本熱傷学会学術集会
    • Place of Presentation
      東京都
    • Related Report
      2011 Research-status Report
  • [Presentation] Clinical feature of primary vein graft in free tissue transfers2011

    • Author(s)
      Mitsuru Nemoto, Kenici Kumazawa, Shinsuke Ishikawa, Masataka Uchino, Eiju Uchinuma
    • Organizer
      6th congress of the world society for reconstructive microsurgery
    • Place of Presentation
      Helsinki,Finland
    • Related Report
      2011 Research-status Report
  • [Presentation] 救急隊による病院前熱傷評価の検討2011

    • Author(s)
      柳澤正之、熊澤憲一、新美裕太、根本 充、秋本峰克、内沼栄樹
    • Organizer
      第19回新宿熱傷フォーラム
    • Place of Presentation
      東京都新宿区
    • Related Report
      2011 Research-status Report
  • [Presentation] 足底荷重部再建例の検討2011

    • Author(s)
      黒柳美里、根本 充、秋本峰克、熊澤憲一、内沼栄樹
    • Organizer
      第38回日本マイクロサージャリー学会学術集会
    • Place of Presentation
      新潟県新潟市
    • Related Report
      2011 Research-status Report
  • [Presentation] 整容的修正術を要した四肢再建例の検討 -機能的、整容的四肢再建     を目指して-2011

    • Author(s)
      根本 充、熊澤憲一、石川心介、柏木慎也、秋本峰克、内沼栄樹
    • Organizer
      第38回日本マイクロサージャリー学会学術集会
    • Place of Presentation
      新潟県新潟市
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒアルロン酸とコラーゲンを組み合わせた癒着防止膜の開発 第2報 ー機能的評価ー

    • Author(s)
      根本 充、熊澤憲一、内沼栄樹
    • Organizer
      第57回日本手外科学会学術集会
    • Place of Presentation
      兵庫県神戸市
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒアルロン酸とコラーゲンを組み合わせた新規癒着防止膜の開発 第1報 ー組織学的評価ー

    • Author(s)
      根本 充、熊澤憲一、内沼栄樹
    • Organizer
      第55回日本手外科学会学術集会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2012 Research-status Report
  • [Presentation] 再接着指の術後可動域の検討

    • Author(s)
      熊澤憲一、根本 充、石川心介、秋本峰克、内沼栄樹
    • Organizer
      第55回日本手外科学会学術集会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2012 Research-status Report
  • [Presentation] 当センターにおける化学損傷の臨床的検討

    • Author(s)
      吉竹俊裕、熊澤憲一、黒柳美里、根本 充、武田 啓、内沼栄樹
    • Organizer
      第20回新宿熱傷フォーラム
    • Place of Presentation
      東京都新宿区
    • Related Report
      2012 Research-status Report
  • [Presentation] 簡易で安全な浅腓腹動脈皮弁による膝部皮膚軟部組織欠損再建

    • Author(s)
      根本 充、熊澤憲一、内沼栄樹
    • Organizer
      第39回日本マイクロサージャリー学会学術集会
    • Place of Presentation
      福岡県北九州市
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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