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Development of implantable volitional controlled electrical stimulation device for treatment of facial paralysis

Research Project

Project/Area Number 23592654
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Plastic surgery
Research InstitutionKyorin University

Principal Investigator

TAKUSHIMA Akihiko  杏林大学, 医学部, 教授 (90272541)

Co-Investigator(Kenkyū-buntansha) MURAOKA Yoshihiro  早稲田大学, 人間科学学術院, 准教授 (10338254)
Co-Investigator(Renkei-kenkyūsha) KURITA Masakazu  杏林大学, 医学部医学科, 助教 (20424111)
SHIRAISHI Tomohiro  杏林大学, 医学部医学科, 助教 (40433726)
HARII Kiyonori  杏林大学, 医学部医学科, 教授 (50111539)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords顔面神経麻痺 / 機能的筋刺激装置 / 再建術 / 機能的筋刺激 / 神経再生 / 電気刺激 / 電池 / 筋電図 / 神経再建術 / 動的再建術 / 非接触充電
Research Abstract

For the treatment of established facial paralysis, we primary aimed to develop volitional controlled implantable functional electrical stimulation device. Design of electrical circuit which is minimized for implantation was optimised. Therefore, way of electrical supply to subcutaneously implanted device was searched. Especially non-touching charging system was aimed but fialed in the experimental settings. On the other hand, we investigated the utility of distal side of nerve stump for the innervation of transplanted muscle segment during free neurovascular muscle transfer with animal experimental model and clinical cases. The utility was confirmed both experimentally and clinically.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (38 results)

All 2013 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 5 results) Presentation (28 results) Book (2 results)

  • [Journal Article] Reinnervation of segmented latissimus dorsi muscle with the distal stump of the thoracodorsal nerve: A preliminary experimental study in rats.2013

    • Author(s)
      Kurita M, Takushima A, Shiraishi T, Kinoshita M, Ozaki M, Harii K
    • Journal Title

      Microsurgery

      Volume: 33 Issue: 7 Pages: 545-550

    • DOI

      10.1002/micr.22164

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recycle of temporal muscle in combination with free muscle transfer in the treatment of facial paralysis.2013

    • Author(s)
      Kurita M, Takushima A, Shiraishi T, Kinoshita M, Ozaki M, Harii K
    • Journal Title

      Journal of Plastic Reconstructive Aesthtetic Surgery

      Volume: 66 Issue: 7 Pages: 991-995

    • DOI

      10.1016/j.bjps.2012.12.006

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【悪性腫瘍(第3集)】がん治療に対する形成外科の関わり2013

    • Author(s)
      多久嶋亮彦
    • Journal Title

      杏林医学会雑誌

      Volume: 44 (3) Pages: 171-178

    • Related Report
      2013 Final Research Report
  • [Journal Article] Fifteen-year survey of one-stage latissimus dorsi muscle transfer for treatment of longstanding facial paralysis2013

    • Author(s)
      Takushima A, Harii K, Asato H, Kurita M, Shiraishi T
    • Journal Title

      Journal of Plastic Reconstructive and Aesthetic Surgery

      Volume: 66(1) Issue: 1 Pages: 29-36

    • DOI

      10.1016/j.bjps.2012.08.004

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fifteen-year survey of one-stage latissimus dorsi muscle transfer for treatment of longstanding facial paralysis.2013

    • Author(s)
      Takushima A, Harii K, Asato H, Kurita M, Shiraishi T
    • Journal Title

      J Plast Reconstr Aesthet Surg

      Volume: 66 Pages: 29-36

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 顔面神経麻痺に対する美容外科的アプローチ2012

    • Author(s)
      多久嶋亮彦
    • Journal Title

      医学のあゆみ

      Volume: 242 Pages: 818-819

    • Related Report
      2013 Final Research Report
  • [Journal Article] 形成外科的縫合法2011

    • Author(s)
      多久嶋亮彦
    • Journal Title

      臨床整形外科

      Volume: 46 Pages: 1134-1137

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 重瞼術埋没法私の方法2011

    • Author(s)
      多久嶋亮彦,石井秀典
    • Journal Title

      形成外科

      Volume: 54巻増刊

    • Related Report
      2013 Final Research Report
  • [Presentation] Double innervated latissimus dorsi muscle transfer for longstanding paralyzed face2013

    • Author(s)
      Takushima A
    • Organizer
      XII International Facial Nerve Symposium
    • Place of Presentation
      Boston, USA
    • Year and Date
      2013-06-30
    • Related Report
      2013 Final Research Report
  • [Presentation] One-stage latissimus dorsi muscle transfer for facial reanimation2013

    • Author(s)
      Takushima A
    • Organizer
      Video with demonstration of the surgical technizue
    • Place of Presentation
      22th Congress of the Spanish Society of Oral and Maxillofacial Surgery, Cordoba, Spain
    • Year and Date
      2013-06-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Latissimus dorsi versus gracilis FFMT for facial reanimation2013

    • Author(s)
      Takushima A
    • Organizer
      Takushima A
    • Place of Presentation
      22th Congress of the Spanish Society of Oral and Maxillofacial Surgery, Cordoba, Spain
    • Year and Date
      2013-06-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 健側顔面神経と患側咬筋神経の二重支配を受ける広背筋移植術による笑いの再建2013

    • Author(s)
      多久嶋亮彦,栗田昌和,白石知大,波利井清紀
    • Organizer
      第36回日本顔面神経研究会
    • Place of Presentation
      沖縄
    • Year and Date
      2013-04-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 遊離広背筋移植における移植筋体遠位側神経の縫合による逆行性神経再支配―臨床的検証2013

    • Author(s)
      栗田昌和、多久嶋亮彦、成田圭吾、白石知大、菅浩隆、波利井清紀
    • Organizer
      日本マイクロ―サージャリ―学会40周年記念学術集会
    • Place of Presentation
      盛岡市民文化ホール(マリオス)いわて県民情報交流センター(アイーナ)、盛岡市、岩手県
    • Related Report
      2013 Final Research Report
  • [Presentation] 顔面神経損傷に対する神経縫合・神経移行・神経移植・神経血管柄付き遊離筋肉移植2013

    • Author(s)
      多久嶋亮彦、波利井清紀
    • Organizer
      第40回日本マイクロサージャリー学会
    • Place of Presentation
      岩手
    • Related Report
      2013 Final Research Report
  • [Presentation] Double innervated latissimus dorsi muscle transfer2013

    • Author(s)
      Takushima A
    • Organizer
      22th Congress of the Spanish Society of Oral and Maxillofacial Surgery
    • Place of Presentation
      Cordoba, Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] 小児顔面神経麻痺に対する遊離筋肉移植術による「笑い表情」の再建2013

    • Author(s)
      栗田昌和、多久嶋亮彦、白石知大、波利井清紀
    • Organizer
      第36回日本顔面神経研究会ロワジール那覇
    • Place of Presentation
      沖縄県
    • Related Report
      2013 Final Research Report
  • [Presentation] 小児顔面神経麻痺に対する遊離筋肉移植術による「笑い表情」の再建2013

    • Author(s)
      栗田昌和、多久嶋 亮彦、白石 知大、波利井 清紀
    • Organizer
      第36回日本顔面神経研究会
    • Place of Presentation
      ロワジール那覇 沖縄県
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neurotization of Segmented Lattisimus Dorsi Muscle Through Distal Nerve Stump Dissected from Muscle Berry.2013

    • Author(s)
      Kurita M, Takushima A, Yamazaki K, Eto H, Harii K
    • Organizer
      12th international facial nerve symposium
    • Place of Presentation
      Boston, MA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 遊離広背筋移植における移植筋体遠位側神経の縫合による逆行性神経再支配―臨床的検証2013

    • Author(s)
      栗田昌和、多久嶋亮彦、成田圭吾 白石知大、菅浩隆。波利井清紀
    • Organizer
      日本マイクロ―サージャリ―学会40周年記念学術集会
    • Place of Presentation
      盛岡市民文化ホール(マリオス)いわて県民情報交流センター(アイーナ)、盛岡市、岩手県
    • Related Report
      2013 Annual Research Report
  • [Presentation] Technical Development of Free Muscle Transfer for Facial Reanimation2012

    • Author(s)
      Takushima A
    • Organizer
      The 7th International & 10th National Conference on Oral and Maxillofacial Surgery
    • Place of Presentation
      西安,中国
    • Year and Date
      2012-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Lower extremity reconstruction using free flaps2012

    • Author(s)
      Takushima A, Miyamoto S, Kurita M, Shiraishi T, Harii K
    • Organizer
      The 4th Congress of the World Union of Wound Healing Societies
    • Place of Presentation
      Yokohama
    • Year and Date
      2012-09-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 顔面神経麻痺に対する形成外科的治療2012

    • Author(s)
      多久嶋亮彦
    • Organizer
      日本頭頸部癌学会主催第3回教育セミナー
    • Place of Presentation
      島根
    • Year and Date
      2012-06-06
    • Related Report
      2013 Final Research Report
  • [Presentation] The progress of technical development for facial reanimation2012

    • Author(s)
      Takushima A, Harii K, Asato H, Kurita M, Shiraishi T
    • Organizer
      The 11th Japan- Korea Congress of Plastic & Reconstructive Surgery
    • Place of Presentation
      Hyogo
    • Year and Date
      2012-05-19
    • Related Report
      2013 Final Research Report
  • [Presentation] ガイドラインシンポジウム「顔面神経麻痺」2012

    • Author(s)
      多久嶋亮彦
    • Organizer
      第55回日本形成外科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 移植筋体遠位側神経の縫合による逆行性再支配の実験的検証―新規の経路を介した神経再支配迅速化の試みシンポジウム「Long march~組織再生迅速化の試み」2012

    • Author(s)
      栗田昌和、多久嶋亮彦、山崎和紀、江藤ひとみ、成田圭吾、波利井清紀
    • Organizer
      第21回日本形成外科学会基礎学術集会
    • Place of Presentation
      ホテルリステル猪苗代、福島県
    • Related Report
      2013 Final Research Report
  • [Presentation] 下口唇の対称性獲得を目的とした健側口角下制筋切除術の経験2012

    • Author(s)
      栗田昌和、多久嶋亮彦、白石知大、波利井清紀
    • Organizer
      第35回日本顔面神経研究会
    • Place of Presentation
      ホテルリステル猪苗代、耶麻郡、福島県
    • Related Report
      2013 Final Research Report
  • [Presentation] 移植筋体遠位側神経の縫合による逆行性神経再支配の実験的検証2012

    • Author(s)
      栗田昌和、多久嶋亮彦、白石知大、波利井清紀
    • Organizer
      第35回日本顔面神経研究会
    • Place of Presentation
      ホテルリステル猪苗代、耶麻郡、福島県
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Experimental verification of neurotization of segmented lattisimus dorsi muscle through distal nerve stump dissected from muscle berry2012

    • Author(s)
      Kurita M, Yamazaki K, Takushima A, Harii K
    • Organizer
      The 11th Japan-Korea congress of plastic and reconstructive surgery
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Hyogo, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of implantable Functional Electrical Stimulation device Controlled with EMG of Contralateral Healthy Hemiface for Paralyzed Face2012

    • Author(s)
      Kurita M, Muraoka Y, Takushima A, Harii K
    • Organizer
      Annual meetings of American Society for Reconstructive Microsurgery
    • Place of Presentation
      Red Rock Casino Resort & Spa,Las Vegas,Nevada USA (Panel Discussion)
    • Related Report
      2013 Final Research Report
  • [Presentation] he progress of technical development for facial reanimation2012

    • Author(s)
      Takushima A, Harii K, Asato H, Kurita M, Shiraishi T
    • Organizer
      The 11th Japan-Korea congress of plastic and reconstructive surgery
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Hyogo
    • Related Report
      2012 Research-status Report
  • [Presentation] Development of implantable Functional Electrical Stimulation Device Controlled with EMG of Contralateral Healthy Hemiface for Paralyzed Face2012

    • Author(s)
      Masakazu Kurita, Akihiko Takushima, Tomohiro Shiraishi, Kiyonori Harii, Yoshihiro Muraoka
    • Organizer
      AMERICAN SOCIETY FOR RECONSTRUCTIVE MICROSURGERY 2012 ANNUAL MEETING(招待講演)
    • Place of Presentation
      Las Vegas
    • Related Report
      2011 Research-status Report
  • [Presentation] Reanimation of Paralyzed Face with Free Muscle Transfer -Our history from the first case to the present- Instructional Course for Facial Paralysis Reconstruction2011

    • Author(s)
      Takushima A
    • Organizer
      Pre-congress Workshop, 2011 Chang Gung Mayo Symposium in Reconstructive Surgery
    • Place of Presentation
      Linkou, Taiwan
    • Year and Date
      2011-10-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 15-years Survey of One-stage Latissimus Dorsi Muscle Transfer for Treatment of Long-standing Facial Paralysis2011

    • Author(s)
      Takushima A
    • Organizer
      XI International Microsurgical Symposium
    • Place of Presentation
      Botucatu, Brazil
    • Year and Date
      2011-09-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 顔面神経麻痺に対する神経・血管柄付き遊離筋肉移植術---始まりから現在までの変遷---2011

    • Author(s)
      多久嶋亮彦、波利井清紀
    • Organizer
      大阪マイクロサージャリー研究会
    • Place of Presentation
      大阪
    • Year and Date
      2011-07-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 側頭筋移行による頬部動的再建術後に、眼臉部への側頭筋の再移行術と頬部への遊離広背筋移植術を行った4症例の経験2011

    • Author(s)
      栗田昌和、多久嶋亮彦、白石知大、波利井清紀
    • Organizer
      第34回日本顔面神経研究会
    • Place of Presentation
      京王プラザホテル新宿区東京都
    • Year and Date
      2011-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 15-years Survey of One-stage Latissimus Dorsi Muscle Transfer for Treatment of Long-standing Facial Paralysis2011

    • Author(s)
      Takushima A
    • Organizer
      The 16th World Congress of the International Confederation for Plastic
    • Place of Presentation
      Reconstructive and Aesthetic Surgery, Vancouver, Canada
    • Year and Date
      2011-05-24
    • Related Report
      2013 Final Research Report
  • [Book] 皮膚科・形成外科疾患.臨床工学講座臨床医学総論2012

    • Author(s)
      多久嶋亮彦
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2013 Final Research Report
  • [Book] 形成外科.外科医のための循環器必須知識2011

    • Author(s)
      多久嶋亮彦
    • Publisher
      メジカルビュー社
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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