The mechanism of adipose-derived stem cells on wound healing and less scarring
| Project/Area Number |
23592655
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KOMOTO Masakazu 順天堂大学, 医学部, 助手 (20159126)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 再生医学 / 幹細胞 / 創傷治癒 / アポトーシス |
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| Research Abstract |
Previous researches have demonstrated that adipose-derived stem cells (ASCs) possess the potential for not only tissue regeneration but also acceleration of wound healing with less scarring. However, the mechanisms of scar reduction remain still elusive. Therefore, we investigated the detail mechanism including angiogenesis and apoptotic effect of myofibroblasts/fibroblasts using murine diabetic would model. Results showed that epithelization rates, capillary density and the indices of myofibroblast apoptosis, and fibroblast apoptosis were all higher in ASCs group than in the control group mainly within 2 weeks after injury. These findings suggest that ASCs accelerate skin would healing at the same time as inducing apoptosis of both myofibroblasts and fibroblasts, thereby reducing scar formation in a diabetic murine model.
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Report
(4 results)
Research Products
(38 results)
