| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
Bone marrow strormal cells and bone marrow-derived mononuclear cells have studied as effective transplants for the spinal cord acute crush injury. In this study, we showed that BMCs and BM-MNCs have showed as effective transplants for the spinal cord crush injury in sub-acute and chronic stages. The groups of tansplantaion have beneficial effects on tissue repair and axonal outgrowth, leading to improve locomotion of rats. Furthermore, we directly transplanted the BM-MNCs with artificial matrix Collagen gel or Alginate gel of heparin binding protein) in acute spinal cord cut injury. The covalently crosslinked heparin and alginate gel sustains release of bFGF in vitro. We indicated that alginate gel is better than collagen in the view point of affinity and cell toxicity. In another study, we applied the fat transplantation and skin ulcer. This novel material accelerates wound closure and leads effective fat graft with angiogenesis in histologically.
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