Trasnplantation of autologous bone marrow cells for treatment of subacute and chronic spinal cord injury and another disease.
| Project/Area Number |
23592663
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | The Tazuke Kofukai |
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Principal Investigator |
MASAYOSHI Ota 公益財団法人田附興風会, 医学研究所 第5研究部, 研究員 (20462278)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Yoshihisa 公益財団法人田附興風会, 医学研究所 第5 研究部, 研究主幹 (30243025)
IDE Chizuka 藍野大学, 医療保健学部, 藍野再生医療研究所・教授 (70010080)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 神経再生 |
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| Research Abstract |
Bone marrow strormal cells and bone marrow-derived mononuclear cells have studied as effective transplants for the spinal cord acute crush injury. In this study, we showed that BMCs and BM-MNCs have showed as effective transplants for the spinal cord crush injury in sub-acute and chronic stages. The groups of tansplantaion have beneficial effects on tissue repair and axonal outgrowth, leading to improve locomotion of rats. Furthermore, we directly transplanted the BM-MNCs with artificial matrix Collagen gel or Alginate gel of heparin binding protein) in acute spinal cord cut injury. The covalently crosslinked heparin and alginate gel sustains release of bFGF in vitro. We indicated that alginate gel is better than collagen in the view point of affinity and cell toxicity. In another study, we applied the fat transplantation and skin ulcer. This novel material accelerates wound closure and leads effective fat graft with angiogenesis in histologically.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Effects of bone marrow stromal cell transplantation through CSF on the subacute and chronic spinal cord injury in rats2013
Author(s)
Nakano N, Nakai Y, Seo TB, Homma T, Yamada Y, Ohta M, Suzuki Y, Nakatani T, Fukushima M, Hayashibe M, Ide C
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Journal Title
PloS ONE
Volume: 8(9)
Issue: 9
Pages: e73494-e73494
DOI
Related Report
Peer Reviewed
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[Journal Article] Evaluation of methods for cell harvesting and the biological properties at successive passages of canine bone marrow stromal cells2012
Author(s)
Nishida H, Shoji Y, Nakamura M, Hatoya S, Sugiura K, Yamate J, Kuwamura M, Kotani T, Nakayama M, Suzuki Y, Ide C, Inaba T
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Journal Title
Am J Vet Res
Volume: 3(11)
Pages: 1832-1840
Related Report
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