Novel Strategy to prevent ischemia/reperfusion injury that overcomes disadvantages of antioxidant agents
Project/Area Number |
23592672
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Emergency medicine
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Research Institution | Oita University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TESHIMA Yasushi 大分大学, 医学部, 助教 (10457608)
HAGIWARA Satoshi 大分大学, 医学部, 講師 (50527661)
SAIKAWA Tetsunori 大分大学, 医学部, 教授 (60145365)
NOGUCHI Takayuki 大分大学, 医学部, 教授 (90156183)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 心房細動 / メタボリック症候群 / 酸化ストレス / 虚血再灌流障害 |
Research Abstract |
We examined the hypothesis that leptin signaling contributes to the atrial fibrosis and atrial fibrillation (AF) evoked by angiotensin II (AngII). Male CL57/B6 (CNT) and leptin-deficient ob/ob mice (Ob) were subcutaneously infused with AngII. In CNT-AngII mice, leptin expression in the left atrium was upregulated. Transesophageal burst pacing induced AF in 88% of CNT-AngII mice, but not in Ob-AngII mice (0%). In isolated perfused hearts, AF was induced only in CNT-AngII mice (67%). Inter-atrial conduction time was prolonged in CNT-AngII mice, but not in Ob-AngII mice. In cultured SD rat atrial fibroblasts, AngII treatment increased leptin expression. Addition of leptin increased TGF-beta1, alpha-SMA, MCP-1 and RANTES expressions in SD rat atrial fibroblasts but not in Zucker rat atrial fibroblasts. These observations demonstrate that leptin signaling is essential for the development of atrial fibrosis and AF evoked by AngII.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Establishment of a model of atrial fibrillation associated with chronic kidney disease in rats and the role of oxidative stress.2012
Author(s)
Fukunaga N, Takahashi N, Hagiwara S, Kume O, Fukui A, Teshima Y, Shinohara T, Nawata T, Hara M, Noguchi T, Saikawa T.
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Journal Title
Heart Rhythm
Volume: 12
Issue: 12
Pages: 2023-31
DOI
Related Report
Peer Reviewed
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[Journal Article] Activation of CaMKII as a key regulator of reactive oxygen species production in diabetic rat heart.2012
Author(s)
Nishio S, Teshima Y, Takahashi N, Thuc LC, Saito S, Fukui A, Kume O, Fukunaga N, Hara M, Nakagawa M, Saikawa T.
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Journal Title
J Mol Cell Cardiol
Volume: 52
Pages: 1103-1111
Related Report
Peer Reviewed
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[Journal Article] Candesartan restored cardiac Hsp72 expression and tolerance against reperfusion injury in hereditary insulin-resistant rats.2011
Author(s)
Taniguchi Y, Takahashi N, Fukui A, Nagano-Torigoe Y, Thuc LC, Teshima Y, Shinohara T, Wakisaka O, Ooie T, Murozono Y, Yufu K, Nakagawa M, Hara M, Yoshimatsu H, Saikawa T.
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Journal Title
Cardiovasc Res
Volume: 23
Pages: 433-435
Related Report
Peer Reviewed
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[Presentation] Role of indoxyl sulfate, a major uremic toxin, in pathogenesis of atrial fibrillation associated with chronic kidney disease2014
Author(s)
Aoki K, Takahashi N, Kondo H, Saito S, Nishio S, Fukui A, Shinohara T, Teshima Y, Shibata T
Organizer
第78回日本循環器学会総会・学術集会
Place of Presentation
東京
Related Report
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[Presentation] Role of Leptin Signaling in Pathogenesis of Atrial Fibrosis and Fibrillation.2012
Author(s)
Fukui A, Takahashi N, Fukunaga N, Thuc L, Kume O, Miyazaki H, Wzaki K, Shinohara T, Teshima Y, Yufu K, Hara M, Nakagawa M, Yoshimatsu H, Saikawa T.
Organizer
第76回日本循環器学会学術集会
Place of Presentation
福岡
Related Report
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[Presentation] Role of Leptin Signaling in Pathogenesis of Atrial Fibrosis and Fibrillation2011
Author(s)
Fukui A, Takahashi N, Teshima Y, Yufu K, Nakagawa M, Saikawa T, Kume O, Wakisaka O, Shinohara T, Hara M, Yoshimatsu H.
Organizer
Annual meeting of American Heart Associatoin
Place of Presentation
orlando
Related Report