Effects of Newly synthetized antioxydant DHLHZn on Bleomycine induced pulmonary fibrosis

• Project/Area Number: 23592673
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Oita University
• Principal Investigator: NOGUCHI Takayuki 大分大学, 医学部, 教授 (90156183)
• Co-Investigator(Kenkyū-buntansha): KUSAKA Junya 大分大学, 医学部, 客員研究員 (00567951)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 肺線維症 / ブレオマイシン / 抗酸化作用 / α-リポ酸誘導体 / αリポ酸誘導体 / アルファリポ酸誘導体 / αリポ酸 / 誘導体 / 抗酸化 / 酸化ストレス / 呼吸障害

Research Abstract

This study investigated the reduction in acute pulmonary fibrosis after Sodium Zinc Histidine Dithiooctanamide (DHL-HisZn) which was the zinc chelate of the alpha-lipoic acid derivative of the de novo synthesis, to inhibit oxidative stress induced by bleomycin in a rat model. After the administration of bleomycin, the animals were sacrificed and lung and serum samples were harvested and evaluated. This study results indicate that treatment with DHL-HisZn can alleviate pulmonary fibrosis in a model of bleomycin.

Research Products

• [Presentation] αリポ酸誘導体およびビタミンE誘導体の可能性 (2011)
  • Author(s): 野口隆之
  • Organizer: 第2回癌・炎症とαリポ酸研究会
  • Place of Presentation: ホテル白菊(大分)
  • Year and Date: 2011-11-12
• [Presentation] 新規αリポ酸誘導体DHL-HisZnを用いたブレオマイシン誘発肺線維症モデルでの治療効果の検討 (2011)
  • Author(s): 藤田和也
  • Organizer: 公益社団法人日本麻酔科学会九州麻酔科学会第49回大会
  • Place of Presentation: JA・AZMホール(宮崎)
  • Year and Date: 2011-09-17
• [Patent(Industrial Property Rights)] 肺線維化疾患の予防または治療薬
  • Inventor(s): 野口隆之
  • Industrial Property Rights Holder: 大分大学
  • Overseas