Change of brain blood flow with BOLD MRI during expired gas contorol

• Project/Area Number: 23592677
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Nagoya City University
• Principal Investigator: ITO Shoji 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (40254289)
• Co-Investigator(Kenkyū-buntansha): SASANO Hiroshi 名古屋市立大学, 大学院医学研究科, 准教授 (20215742)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 呼気ガスコントロール / 二酸化炭素 / 酸素 / 脳血流 / BOLD MRI / 呼気終末二酸化炭素分圧 / 呼気週末酸素分圧 / Functional MRI / 呼気終末酸素分圧 / functional MRI

Research Abstract

The simulator for elimination of carbon dioxide (CO2) and adsorption of oxygen (O2) was created, based on our CO2 & O2 transport model in the body. The auto end-tidal carbon dioxide & oxygen pressure (PETCO2&O2) independent control system installing the simulator was developed. The system was applied to subjects with spontaneous breathing and the PETCO2&O2 control tests were performed. In consequence the precise and independent PETCO2&O2 control method was established. We are investigating the relationships between PETCO2&O2 data and brain blood flow from BOLD fMRI image during PETCO2&O2 up & down step change in spontaneous breathing subjects.

Research Products

• [Journal Article] Tidal volume and airway pressure under percutaneous transtracheal ventilation without a jet ventilator : comparison of high-flow oxygen ventilation and manual ventilation in complete and incomplete upper airway obstruction models (2013)
  • Author(s): Sasano N, Tanaka A, Muramatsu A, Fujita Y, Ito S, Sasano H, Sobue K
  • Journal Title: J Anesth Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Spinal cord stimulation for a woman with complex regional pain syndrome who wished to get pregnant (2013)
  • Author(s): Ito S, Sugiura T, Azami T, Sasano H, Sobue K
  • Journal Title: J Anesth Volume: 27 Pages: 124-7
  • NAID: 10031165393
  • Peer Reviewed
• [Journal Article] Tidal volume and airway pressure under percutaneous transtracheal ventilation without a jet ventilator: comparison of high-flow oxygen ventilation and manual ventilation in complete and incomplete upper airway obstruction models. (2013)
  • Author(s): Sasano N, Tanaka A, Muramatsu A, Fujita Y, Ito S, Sasano H, Sobue K
  • Journal Title: Journal of Anesthesia Volume: E pub Issue: 3 Pages: 341-6
  • DOI: 10.1007/s00540-013-1733-2
  • Peer Reviewed
• [Journal Article] Spinal cord stimulation for a woman with complex regional pain syndrome who wished to get pregnant. (2013)
  • Author(s): Ito S, Sugiura T, Azami T, Sasano H, Sobue K.
  • Journal Title: Journal of Anesthesia Volume: 27 Issue: 1 Pages: 124-127
  • DOI: 10.1007/s00540-012-1462-y
  • NAID: 10031165393
  • Peer Reviewed
• [Journal Article] Dependence of the gradient between arterial and end-tidal P(CO(2)) on the fraction of inspired oxygen (2011)
  • Author(s): Yamauchi H, Ito S, Sasano H, Azami T, Fisher J, Sobue K
  • Journal Title: Br J Anaesth Volume: 107 Issue: 4 Pages: 631-5
  • DOI: 10.1093/bja/aer171
  • Peer Reviewed
• [Presentation] 硫酸アトロピンを投与するとなぜ呼気終末二酸化炭素分圧が上昇するのか? (2013)
  • Author(s): 伊藤彰師、川島沙織、加藤妙、伊藤恭史、森島徹朗、祖父江和哉
  • Organizer: 日本麻酔科学会第60回学術集会
  • Place of Presentation: 札幌
• [Presentation] 硫酸アトロピンを投与するとなぜ呼気終末二酸化炭素分圧が上昇するのか？ (2013)
  • Author(s): 伊藤彰師,川島沙織,加藤 妙,伊藤恭史,森島徹朗,祖父江和哉
  • Organizer: 日本麻酔科学会第60回学術集会
  • Place of Presentation: ロイトン札幌（北海道）
• [Presentation] 硫酸アトロピンを投与するとなぜPETCO2が上昇するのか？ (2013)
  • Author(s): 伊藤彰師、川島沙織、加藤 妙、伊藤恭史、森島徹朗、祖父江一哉
  • Organizer: 日本麻酔科学会第60回学術集会
  • Place of Presentation: 札幌 ロイトン札幌、ホテルさっぽろ芸文館、札幌市教育文化会館、札幌プリンスホテル
• [Presentation] 高濃度吸入気酸素濃度は動脈血-呼気終末期二酸化炭素分圧較差と肺胞死腔を増加させる (2012)
  • Author(s): 山内浩揮、伊藤彰師、祖父江和哉
  • Organizer: 日本麻酔科学会第59回学術集会
  • Place of Presentation: 神戸
• [Presentation] 当院ICUにおける一酸化窒素吸入療法の現状 (2012)
  • Author(s): 青木智史、伊藤彰師、冨田麻衣子、小嶋大樹、笹野寛、森島徹朗、伊藤恭史、加藤妙、鈴木悦子、祖父江和哉
  • Organizer: 第39回日本集中治療医学会学術集会
  • Place of Presentation: 千葉
• [Presentation] 高濃度吸入気酸素濃度は動脈血-呼気終末期二酸化炭素分圧較差と肺胞死腔を増加させる (2012)
  • Author(s): 山内浩揮、伊藤彰師、祖父江和哉
  • Organizer: 日本麻酔科学会第59回学術集会
  • Place of Presentation: 神戸 神戸ポートピアホテル・神戸国際展示場
• [Presentation] 当院ICUにおける一酸化窒素吸入療法の現状 (2012)
  • Author(s): 青木智史、伊藤彰師、富田麻衣子、小島大樹、笹野 寛、祖父江和哉
  • Organizer: 第39回日本集中治療医学会
  • Place of Presentation: 幕張、千葉