Research Project
Grant-in-Aid for Scientific Research (C)
CCAAT/enhancer-binding protein β(C/EBPβ) could play crucial roles on cellular differentiation and functional maintenance in various types of somatic cells. Granulocyte production increases in response to increased neutrophil demand following infectious stress. In this study, we investigated the role of C/EBPβ at hematopoietic stem cell levels in stress-induced granulopoiesis. C/EBPβ was upregulated at the protein level in all the five distinct subpopulations of granulopoiesis in a mouse candidemia model. Using a C/EBPβ knockout mouse model, the role of C/EBPβ in cell cycle acceleration and proliferation of hematopoietic stem/progenitors was also confirmed. These data suggest that C/EBPβ is a significant controlling factor involved in the efficient amplification of early granulocyte precursors during emergency granulopoiesis.
All 2015 2014 2013 2012 2011 Other
All Journal Article (21 results) (of which Peer Reviewed: 20 results, Open Access: 1 results, Acknowledgement Compliant: 1 results) Presentation (14 results) (of which Invited: 3 results) Book (1 results)
Cancer Science
Volume: *
Clinical and Experimental Metastasis
Volume: 32 Issue: 8 Pages: 2245-55
10.1002/stem.1701
化学療法の領域
Volume: 30 Pages: 631-640
BMJ Case Rep
Volume: May 23 Pages: bcr2014203764-bcr2014203764
10.1136/bcr-2014-203764
Journal of Intensive Care
Volume: 2 Pages: 36-36
Pediatr Crit Care Med
Volume: 15 Issue: 2 Pages: 182-182
10.1097/pcc.0000000000000024
J Intensive Care
Volume: 1 Pages: 2-2
Stem Cells
Volume: 32 Issue: 3 Pages: 730-740
10.1002/stem.1555
臨床血液
Volume: 54 Pages: 27-38
10031196300
PLoS One
Volume: 8 Issue: 1 Pages: e54862-e54862
10.1371/journal.pone.0054862
120005242481
Leukemia
Volume: 27 Issue: 3 Pages: 619-628
10.1038/leu.2012.258
120005466670
Intensive Care Med
Volume: 38 Issue: 7 Pages: 1191-7
10.1007/s00134-012-2550-z
J Immunol
Volume: 198 Issue: 9 Pages: 4546-4555
10.4049/jimmunol.1103007
Chest
Volume: 141 Pages: 281-3
Volume: 13
nfection
Volume: 39 Issue: 4 Pages: 319-25
10.1007/s15010-011-0116-6
J Anesth
Volume: 25 Issue: 3 Pages: 321-9
10.1007/s00540-011-1130-7
10029022846
Infection
Volume: 40 Issue: 2 Pages: 229-230
10.1007/s15010-011-0222-5
Cancer Letter
Volume: 312(2) Issue: 2 Pages: 228-34
10.1016/j.canlet.2011.08.009
Cancer Sci
Volume: 102 Issue: 3 Pages: 591-6
10.1111/j.1349-7006.2010.01813.x
10029291246
Volume: 312(1) Issue: 1 Pages: 91-100
10.1016/j.canlet.2011.08.002