Immunology and regenerative medicine-based approach to acute lung injury
| Project/Area Number |
23592681
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 炎症性肺疾患 / 急性呼吸促迫症候群 / ARDS |
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| Research Abstract |
1) We examined the mechanisms of exaggerated bleomycin-induced acute lung injury in IL-17-deficient mice, and found that IL-12-expressing dendritic cells were increased in the knockout mice. 2) In human endothelial cells, in association with the accelerated response, gene expression of TLR and NOD families were significantly affected under hyperoxia. 3) We examined the differentiation of human embryonic stem cells to alveolar epithelial cells under air-liquid interface, using SPC and AP5 as markers. The expression of SPC was increased at 20 days, but was decreased at 40 days, whereas that of AP5 was increased with time. 4) We examined lung stem cells and progenitor cells in autopsied lungs from patients with ARDS and IPF. In ARDS, accumulation of inflammatory cells in the early phase and metaplastic epithelial cells in the late phase were observed, but Musashi-1 and SPC double positive cells were not observed. In IPF, Musashi-1 and CCSP double positive cells were also not observed.
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Report
(4 results)
Research Products
(77 results)
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[Journal Article] Epidemiology of severe sepsis in Japanese intensive care units: a prospective multicenter study2014
Author(s)
Ogura H, Gando S, Saitoh D, Takeyama N, Kushimoto S, Fujishima S, Mayumi T, Araki T, Ikeda H, Kotani J, Miki Y, Shiraishi S, Suzuki K, Suzuki Y, Takuma K, Tsuruta R, Yamaguchi Y, Yamashita N, Aikawa N.
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Journal Title
J Infect Chemother
Volume: 20
Issue: 3
Pages: 157-62
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis: an analysis from a multicenter, prospective survey of severe sepsis2013
Author(s)
Kushimoto S, Gando S, Saitoh D, Mayumi T, Ogura H, Fujishima S, Araki T, Ikeda H, Kotani J, Miki Y, Shiraishi SI, Suzuki K, Suzuki Y, Takeyama N, Takuma K, Tsuruta R, Yamaguchi Y, Yamashita N, Aikawa N.
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Journal Title
Crit Care
Volume: 17
Issue: 6
Pages: R271-R271
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 敗血症とは?2012
Author(s)
藤島清太郎
Organizer
世界敗血症デー記念講演会
Place of Presentation
東京
Year and Date
2012-09-22
Related Report
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[Presentation] Japanese Association for Acute Medicine Sepsis Registry Special Committee. Quality of care and mortality of severe sepsis and septic shock in Japan2012
Author(s)
Fujishima S, Gando S, Saito D, Mayumi T, Kushimoto S, Shiraishi S, Ogura H, Takuma K, Kotani J, Ikeda H, Yamashita N, Suzuki K, Tsuruta R, et al.
Organizer
American Thoracic Society (ATS) 2012 International Conference
Place of Presentation
米国 San Francisco
Related Report
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